Topic
Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide.
Abstract: Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide.
53 citations
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TL;DR: The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 mg of Pb/kg po, and the chelators nitrilotriacetic acid and sodium citrate increased absorption of lead, as did orange juice, a source of citric acid.
53 citations
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TL;DR: This is the first demonstration that blood Pb(2+) (12µg/dl) concentrations below the WHO-established values increased systolic blood pressure and vascular phenylephrine reactivity.
52 citations
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TL;DR: Weanling and adult rats injected with one of three concentrations of lead acetate for 37 days failed to demonstrate any learning impairments as measured by a Hebb-Williams maze series relative to water injected controls, suggesting the behavioral and physiological effects of lead may be greatest during the earliest developmental stages.
Abstract: Weanling and adult rats injected with one of three concentrations of lead acetate for 37 days failed to demonstrate any learning impairments as measured by a Hebb-Williams maze series relative to water injected controls. Rats at the highest dose level showed clear symptoms of lead poisoning. Pregnant females injected during pregnancy with an asymptomatic dose of lead acetate showed a 100% abortion rate, while 75% of water injected controls delivered litters. Rats whose mothers were injected with asymptomatic doses of lead acetate throughout nursing developed more slowly, weighed less, and demonstrated learning deficits relative to controls. The behavioral and physiological effects of lead may be greatest during the earliest developmental stages.
52 citations
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TL;DR: The findings indicate that Pb combined with Cd induced oxidative damage in the liver and kidney of rats, and metallothionein may be a biochemical environmental indicator.
52 citations