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Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.


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Journal ArticleDOI
01 May 1981-Science
TL;DR: All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.
Abstract: Lead acetate (0.02 or 0.5 percent) was administered to dams throughout the lactation period with half of the litters continuing on lead after weaning. Drug thresholds for d-amphetamine were determined by using the drug-discrimination learning paradigm. All the offspring that had been exposed to lead were less sensitive to the stimulus properties of d-amphetamine irrespective of whether or not they had continued on lead after weaning.

47 citations

Journal ArticleDOI
TL;DR: The lead levels measured in the ovarian follicular fluid seem not to pose a hazard with respect to progesterone secretion by the ovary, and lead seems not to exert a specific effect on the steroidogenesis by cultured human granulosa cells.
Abstract: Lead content of ovarian follicular fluid obtained from 23 women was determined by atomic absorption spectrophotometry. In an in vitro experiment the direct effect of lead on the morphology and on progesterone (P) production by cultured granulosa cells of six women was investigated. Follicular fluid and granulosa cells were obtained from follicular aspirates of women undergoing in vitro fertilization (IVF) and embryo transfer (ET). Granulosa cells were cultured for 48 h to form monolayers in the presence or absence of lead acetate (100-1600 µ M). The effect of the metal proved to be concentration dependent. While 100-400 µ M lead had no effect on the integrity of the monolayer, concentrations as high as 800 µ M or higher inhibited cell adhesion and induced detachment of cells. The lead levels found in follicular fluid were 11.29 - 1.38 µg/L (0.056 - 0.007 µ M). With lead in vitro at 1600 µ M (331.5 mg/L) there resulted a significant decrease in P production by granulosa cells. This concentration is very mu...

47 citations

Journal ArticleDOI
TL;DR: Lead decreased the mitogenic response of peripheral blood lymphocytes to phytohaemagglutinin-P (PHA-P) in birds vaccinated with NDVV and decreased the weights of the bursa of Fabricius, the thymus glands and the spleen relative to bodyweight.

47 citations

Journal ArticleDOI
TL;DR: PCs were demonstrated to have protective, antioxidant, andAnti-ER stress and anti-apoptotic activities in liver damage caused by chronic lead exposure in the Kunming mouse, resulting in decreasing ER stress and apoptosis of liver tissue.
Abstract: Lead is harmful for human health and animals. Proanthocyanidins (PCs), a natural antioxidant, possess a broad spectrum of pharmacological and medicinal properties. However, its protective effects against lead-induced liver damage have not been clarified. This study was aimed to evaluate the protective effect of PCs on the hepatotoxicity of male Kunming mice induced by chronic lead exposure. A total of 70 healthy male Kunming mice were averagely divided into four groups: control group, i.e., the group exposed to lead, the group treated with PCs, and the group co-treated with lead and PCs. The mice exposed to lead were given water containing 0.2% lead acetate. Mice treated in the PCs and PCs lead co-treated groups were given PC (100 mg/kg) in 0.9% saline by oral gavage. Lead exposure caused a significant elevation in the liver function parameters, lead level, lipid peroxidation, and inhibition of antioxidant enzyme activities. The induction of oxidative stress and histological alterations in the liver were minimized by co-treatment with PCs. Meanwhile, the number of Transferase-Mediated Deoxyuridine Triphosphate-Biotin Nick End Labeling (TUNEL)-positive cells was significantly reduced in the PCs/lead co-treated group compared to the lead group. In addition, the lead group showed an increase in the expression level of Bax, while the expression of Bcl-2 was decreased. Furthermore, the lead group showed an increase in the expression level of endoplasmic reticulum (ER) stress-related genes and protein (GRP78 and CHOP). Co-treated with PCs significantly reversed these expressions in the liver. PCs were, therefore, demonstrated to have protective, antioxidant, and anti-ER stress and anti-apoptotic activities in liver damage caused by chronic lead exposure in the Kunming mouse. This may be due to the ability of PCs to enhance the ability of liver tissue to protect against oxidative stress via the Nrf2/ARE signaling pathway, resulting in decreasing ER stress and apoptosis of liver tissue.

47 citations

Journal ArticleDOI
TL;DR: The data presented verify that exposure to lead acetate is toxic to the reproductive axis in male rats, but that increased duration of exposure after 14 days does not further suppress serum testosterone levels or spermatogenesis.
Abstract: This study assesses the significance of duration of exposure on the expression of lead toxicity on the male reproductive system. Male Wistar rats, 52 days old, were treated with 0.0% or 0.6% lead acetate in their water for 7, 14, 30, or 60 days prior to sacrifice. In all cases, the lead-treated groups had blood lead and free erythrocyte protoporphyrin (FEP) levels significantly higher than control animals (P less than 0.0001). Serum testosterone levels and spermatogenesis were suppressed in all lead-treated groups compared to the corresponding controls (P less than 0.05 and P less than 0.001, respectively), except for the group treated for 7 days. The data presented verify that exposure to lead acetate is toxic to the reproductive axis in male rats, but that increased duration of exposure after 14 days does not further suppress serum testosterone levels or spermatogenesis.

47 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202352
2022110
202182
202087
201983
201887