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Lead acetate
About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.
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TL;DR: In this paper, the authors propose a method to solve the problem of "missing links" in a graph.Figs 5-8Figs. 1-4, Fig.
Abstract: ImagesFigs. 5-8Figs. 1-4
140 citations
140 citations
TL;DR: In this paper, the authors investigated behavior in the open field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats and found that lead exposure associated with behavioural alterations.
Abstract: In view of conflicting results in literature concerning lead exposure associated with behavioural alterations, this study investigated behaviour in the open-field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats. Rats were exposed to the metal from conception to weaning by giving the dams 0.5, 2.0 or 4.0 mM lead acetate in drinking water. This regimen did not affect body weight gain of dams or offspring development and had no effect on cerebral weights nor on haematological parameters of 23-day-old rats. In 1-day-old rats, lead accumulated in the blood but not in the brain, whereas both in 23-day-old rats and in dams lead accumulated in blood, kidney and cerebral cortex. In the open-field, lead-exposed groups showed higher locomotor activity in the test session as compared to controls and did not show any decrease in rearing responses in the test, indicating less habituation. Lead-treated rats subjected to a shuttle avoidance task showed no significant increase in avoidance responses between sessions as compared to control, indicating less retention. Moreover, only the control group presented a significant reduction of the footshock escape latency along testing session, suggesting a lead effect on footshock escape acquisition. In the shuttle box, intertrial crossing responses were not affected by lead treatment. The behavioural alterations occurred in animals with blood lead levels in the range 11-50.6 micrograms/dl.
138 citations
TL;DR: Male weanling rats were exposed chronically to drinking solutions containing 25 ppm sodium acetate or 25 ppm lead acetate, and overall response rate increases over the first 40 sessions were similar to those observed previously with higher concentrations of lead.
137 citations
TL;DR: The study of the activity of enzymes is revealed as an effective method to measure the neurotoxic effects produced by the perinatal exposure to lead and/or cadmium.
135 citations