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Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.


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Journal ArticleDOI
TL;DR: A lead acetate-based precursor, as a lead source in CH3NH3PbI3 perovskite, showed potential in rapidly forming homogeneous films with a very smooth interface and large grain growth at relatively low temperatures via multi-step coating.

37 citations

Journal Article
TL;DR: It is suggested that both Pb and Cd can cause a reduction in LH and FSH binding, which significantly alters steroid production in vitro and exerts a direct influence on granulosa cell function.
Abstract: Effects of lead (Pb) and cadmium (Cd) both alone or in combination on the binding of LH and FSH on isolated granulosa cells were studied. Granulosa cell s isolated from proestro us rats were incubated (in vitro) with lead acetate and I or cadmium acetate (0.03 !J.M of Pb or Cd) for I hr. LH binding was dropped to 84% in Pb treated cells, 72.5% in Cd treated cell s and 74.8% in combin ed meta l treated cell s compared to control. FSH binding dropped to 85.5 % in Pb treated cell s, 71.16% in Cd treated cell s and 72.5 % in combined metal treated cells compared to control. Activity of 17~ Hydroxy Steroid Dehydrogenase ( 17~HSDH ), a key steroidogenic enzy me was reduced by 52% in Cd and 37% in combined metal exposed cells whereas Pb exposed cells showed 3 1% reduction in the enzy me activity. Pretreatment with SH groups protectant s (glutathione [GSH], dithiothretol fDTT]) and zin c caused an ameriolation in enzyme activity whereas Zn pretreatment showed an increase in gonadotropin binding in metal exposed cell s. These results suggest that both Pb and Cd can cause a reduction in LH and FSH binding, which significantly alters steroid production in vitro and exerts a direct influence on granulosa cell function.

37 citations

Journal ArticleDOI
TL;DR: Using an allogeneic tumor model, under conditions of similar antigenic stimulation, little effect of lead on T cell-mediated cytotoxicity was observed and the results suggested significant impairment of macrophages function by lead.

37 citations

Journal Article
TL;DR: This report is perhaps the first evidence to show that lead exerts some deleterious effects on testicular steroidogenesis indirectly by decreasing serum levels of gonadotropins.
Abstract: Lead poisoning often prevails in children and industrial workers. The present study was undertaken to evaluate the effects of lead acetate on steroidogenic functions of testis, serum levels of gonadotrophins and testosterone in albino rats. Testicular steroidogenic activity was evaluated by measuring the activities of two steroidogenic key enzymes, ∆ 5 –3β hydroxysteroid dehydrogenase (∆ 5 –3β–HSD) and 17β–hydroxysteroid dehydrogenase (17β–HSD). Administration of lead acetate at a dose of 8mg/kg body weight for 14 days lowered the weights of testes and accessory sex organs, and decreased testicular ∆ 5 –3β – HSD and 17β– HSD activities and serum levels of FSH, LH and testosterone but 7 days of lead acetate administration showed no effect on the above parameters. This report is perhaps the first evidence to show that lead exerts some deleterious effects on testicular steroidogenesis indirectly by decreasing serum levels of gonadotropins.

37 citations

Journal Article
TL;DR: Lead acetate administered intravenously in a mixture with endotoxin preparations potentiates the toxic effect of endotoxin for 14-21 day old meat strain chicks.
Abstract: Lead acetate administered intravenously in a mixture with endotoxin preparations potentiates the toxic effect of endotoxin for 14-21 day old meat strain chicks. A dose of 2.8 mg of lead acetate/100 g body weight is more effective with endotoxin than a dose of 2.5 mg; however, a dose of 3.0 mg or greater is toxic alone. The degree of potentiation appears to be at least 1000 fold and permits toxicity determinations using endotoxin levels ranging from 0.125 µg to 250 µg/chick. Endotoxin preparations made using NaCl, TCA or phenol-water extraction procedures, possessed toxic activity for chicks when tested by this method.

37 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202352
2022110
202182
202087
201983
201887