Lead acetate

About: Lead acetate is a research topic. Over the lifetime, 2636 publications have been published within this topic receiving 69739 citations.

Effect of Alpha Lipoic Acid and Vitamin E on Heavy Metals Intoxication in Male Albino Rats

Abstract: The present study was carried out to investigate the effect of some nutrients on Nutritional and Health status in copper and lead intoxicated male albino rats Fifty male albino rats weighing (125±7 g) were used The rats were divided into 5 groups (10 rats each) The first group received the basal diet only and served as control The second and third groups received copper (copper sulfate in water at dose of 01 mg /kg body weight) with alpha lipoic acid (40 mg/kg body weight) and Vitamin E (20 mg/kg body weight) respectively Fourth and fifth groups received lead (lead acetate in water at a dose of 02 mg/kg body weight) with alpha lipoic acid and Vitamin E respectively At the end of the experimental periods, blood samples were collected from Orbital plexus, the rats sacrificed, organs were weighed, and kept for metal determination The obtained results revealed that alpha lipoic acid (ALA) and vitamin E could improved daily food intake, body weight gain and feed efficiency ratio; reduced copper and lead levels in serum and tissues as well as diminished ALT, AST, urea and creatinine levels in lead and copper intoxicated rats Therefore, the current study recommends that alpha lipoic acid or Vit E (or both of them), should be administered to minimize the toxic effects of lead and copper (Journal of American Science 2010;6(8):56-63) (ISSN: 1545-1003)

The effect of lead exposure on the testis of growing rats.

Abstract: Summary Daily intraperitoneal administration of lead (8 mg/kg) as lead acetate in male rats from 21 till 120 days of age triggered histopathological and biochemical alterations in the testis. Histopathological examination revealed disturbance in spermatogenesis besides Leydig cells degeneration. There was an increase in cholesterol, decrease in ascorbic acid contents and reduction in the glucose-6-phosphate dehydrogenase activity in the testis of lead-treated rats. These alterations suggest that the disturbed steroidogenesis during growing stage may be responsible for altering the germinal function of the testis at maturity.

Effects of lead and hyperthermia on prenatal brain growth of guinea pigs

Abstract: The effects of lead at blood levels of 100 μg/100ml or less on the brains of young animals have not been clearly defined, and little is known of its effects and interactions with other agents on prenatal brain development. This study examined the effects of subclinical doses of lead acetate given to pregnant guinea pigs on the development of the embryo brain. At 9 A.M. on day 20 or 21 of pregnancy, guinea pigs were given 6, 12.5, or 25 mg/kg body weight of 0.5% lead acetate in distilled water by intraperitoneal injection. Some of the animals at each dose rate were also exposed to hyperthermia at 11 A.M. on the day of injection and the following day. Another group was exposed to hyperthermia without lead treatment. A saline-treated control group was used for comparison. Mean levels of lead in blood 1 hour after dosing ranged between 65 and 128 μg/100 ml and at 24 and 72 hours between 65 and 96 μg/100 ml. Brain weights of newborn guinea pigs in the 12.5- and 25-mg lead acetate group were significantly reduced compared with control values. Body weights of all groups receiving lead were not significantly differently different from those of controls. There was no indication of interaction between hyperthermia and lead acetate in doses of 6 or 12.5 mg/kg. At 25 mg/kg plus hyperthermia, there appeared to be a strong synergistic response, with an incidence of 88% micrencephaly compared with 5% in the group given 25 mg/kg without hyperthermia and 46% in the hyperthermia without lead group. The results indicate that subclinical levels of lead can retard prenatal brain growth, and this effect is potentiated by hyperthermia.

Toxicity of lead acetate to female rabbits after chronic subcutaneous administration. 1. Biochemical and clinical effects

Abstract: The effect of chronic subcutaneous administration of lead acetate was studied in female rabbits. The low-dose group (15 animals) received three times a week 0.10–0.20 μg/kg body weight and the high-dose group (15 animals) 0.80–1.20 μg/kg. The control group received the vehicle only. Concentrations of lead in blood in the low-dose group increased to ca. 400 μg/l after 70 days and in the high-dose group to ca. 900 μg/l after 110 days. After 7.5 months eight animals of each group were sacrificed. The remaining rabbits were kept for an additional 4 months without treatment. Blood lead concentrations decreased with a half-time of 60–70 days. During exposure the gain in body weight was lower in the high-dose group than in the control group and the low-dose group. The high-dose group developed slight anaemia and low MCV, MCH and MCHC, and basophilic stippling of erythrocytes. These effects disappeared during recovery. ALAD activity in erythrocytes was very low during exposure in both exposed groups and did not reach control values during recovery. During exposure the concentrations of ZPP and ALA-U increased, but only ALA-U returned to normal during recovery. No other effects of lead on the composition of the urine were observed. No effects were observed on plasma urea and creatinine concentrations. In the highdose group the concentration of ALAD in the liver decreased by 30%. During recovery this effect was no longer present. No effects were seen in cytochrome P-450 content or cytochrome P-450-dependent enzyme activities. Lead was mainly stored in bones, but some also in serveral soft tissues. After recovery the concentrations in soft tissues decreased to a variable degree. In the high-dose group the relative weights of heart and liver increased. These effects disappeared during recovery. At 400 μg lead/l blood no adverse effects were observed that did occur at the high dose level.