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Leading edge

About: Leading edge is a research topic. Over the lifetime, 19415 publications have been published within this topic receiving 233667 citations.


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01 Dec 1966
TL;DR: In this article, a concept for the calculation of the vortex lift of sharp-edge delta wings is presented and compared with experimental data, based on an analogy between vortex lift and the leading-edge suction associated with the potential flow about the leading edge.
Abstract: Polhamus Langley Research Center SUMMARY A concept for the calculation of the vortex lift of sharp-edge delta wings is pre­sented and compared with experimental data. The concept is based on an analogy between the vortex lift and the leading-edge suction associated with the potential flow about the leading edge. This concept, when combined with potential-flow theory modified to include the nonlinearities associated with the exact boundary condition and the loss of the

401 citations

Journal ArticleDOI
TL;DR: During the locomotion on a plane surface of fibroblast-like cells from embryonic chick heart and neonatal mouse muscle, any point on the leading edge undergoes a repetitive protrusion and withdrawal, covering about 5 μm which is quantitatively very similar in the two kinds of cell.

398 citations

Journal ArticleDOI
TL;DR: In this paper, a series of experiments using simplified mechanical models were conducted to investigate the mechanism for the generation of large lift coefficients by insects in hovering flight, and some minor modifications to the Weis-Fogh-Lighthill (1973) explanation of the so-called clap and fling mechanism were suggested.
Abstract: From a series of experiments using simplified mechanical models we suggest certain minor modifications to the Weis-Fogh (1973)–Lighthill (1973) explanation of the so-called ‘clap and fling’ mechanism for the generation of large lift coefficients by insects in hovering flight. Of particular importance is the production and motion of a leading edge, separation vortex that accounts for virtually all of the circulation generated during the initial phase of the ‘fling’ process. The magnitude of this circulation is substantially larger than that calculated using inviscid theory. During the motion that subsequently separates the wings, the vorticity over each of them is convected and combined to become a tip vortex of uniform circulation spanning the space between them. This combined vortex moves downwards as a part of a ring, of large impulse, that is then continuously fed from quasi-steady separation bubbles that move with the wings as they continue to open at a large angle of attack. Such effects are able to account for the large lift forces generated by the insect.

388 citations

Journal ArticleDOI
TL;DR: In this article, the crossflow instability and crossflow/Tollmien-Schlichting wave interactions are analyzed through the numerical solution of the full three-dimensional Navier-Stokes equations including unsteadiness, curvature, and sweep.
Abstract: The computational modeling of the transition process characteristic of flows over swept wings is discussed. Specifically, the crossflow instability and crossflow/Tollmien-Schlichting wave interactions are analyzed through the numerical solution of the full three-dimensional Navier-Stokes equations including unsteadiness, curvature, and sweep. This approach is chosen because of the complexity of the problem and because it appears that regular stability theory is insufficient to explain the discrepancies between experiments and between theory and experiment. The leading edge region of a swept wing will be considered in a three-dimensional spatial simulation with random disturbances as the initial conditions.

381 citations

Journal ArticleDOI
TL;DR: It is shown that Ras is rapidly and transiently activated in response to chemoattractant stimulation and regulates PI3K activity, supporting a mechanism by which localized Ras activation mediates leading edge formation through activation of basalPI3K present on the plasma membrane and other Ras effectors required for chemotaxis.
Abstract: During chemotaxis, receptors and heterotrimeric G-protein subunits are distributed and activated almost uniformly along the cell membrane, whereas PI(3,4,5)P3, the product of phosphatidylinositol 3-kinase (PI3K), accumulates locally at the leading edge. The key intermediate event that creates this strong PI(3,4,5)P3 asymmetry remains unclear. Here, we show that Ras is rapidly and transiently activated in response to chemoattractant stimulation and regulates PI3K activity. Ras activation occurs at the leading edge of chemotaxing cells, and this local activation is independent of the F-actin cytoskeleton, whereas PI3K localization is dependent on F-actin polymerization. Inhibition of Ras results in severe defects in directional movement, indicating that Ras is an upstream component of the cell's compass. These results support a mechanism by which localized Ras activation mediates leading edge formation through activation of basal PI3K present on the plasma membrane and other Ras effectors required for chemotaxis. A feedback loop, mediated through localized F-actin polymerization, recruits cytosolic PI3K to the leading edge to amplify the signal.

355 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023225
2022492
2021491
2020755
2019770
2018732