Topic
Lipid bilayer
About: Lipid bilayer is a research topic. Over the lifetime, 24734 publications have been published within this topic receiving 1075030 citations.
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TL;DR: An algorithm has been developed which identifies alpha-helices involved in the interactions of membrane proteins with lipid bilayers and which distinguishes them from helices in soluble proteins, and suggests four transmembrane helices and a surface-seeking helix in fragment B, the moiety known to have trans Membrane function.
2,157 citations
TL;DR: In this paper, the authors present general ideas derived from the various reports mentioning toxic effects of lipophilic compounds on the membrane lipid bilayer, affecting the structural and functional properties of these membranes.
2,124 citations
TL;DR: A 7-Å resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens and shows that Lipid bilayer regions fill the spaces between the protein molecules.
Abstract: A 7-A resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, alpha-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the spaces between the protein molecules.
2,114 citations
TL;DR: Molecular dynamics simulations were performed on a system consisting of a bilayer of 64 molecules of the lipid dipalmitoylphosphatidylcholine and 23 water molecules per lipid to reproduce the correct density and to give a proper estimate of the area per lipid.
1,822 citations
TL;DR: This review, which is focused on the different stages of membrane permeation induced by representatives of amphipathic alpha-helical antimicrobial and cell non-selective lytic peptides distinguishes between the 'carpet' mechanism, which holds for antimicrobial peptides versus the 'barrel-stave' mechanisms, which hold for cellnon- selective lytics peptides.
1,790 citations