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Lipid metabolism

About: Lipid metabolism is a(n) research topic. Over the lifetime, 27726 publication(s) have been published within this topic receiving 1013244 citation(s). The topic is also known as: lipid metabolic process & GO:0006629. more


Open accessJournal ArticleDOI: 10.1038/414799A
Alan R. Saltiel1, C. Ronald Kahn2Institutions (2)
13 Dec 2001-Nature
Abstract: The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes. more

Topics: Insulin resistance (71%), Insulin receptor (65%), Insulin (64%) more

4,632 Citations

Open accessJournal ArticleDOI: 10.1016/S0021-9258(18)51687-2
Martin Rodbell1Institutions (1)
Topics: Lipid metabolism (62%), Lipolysis (57%), Carbohydrate metabolism (56%) more

4,004 Citations

Journal ArticleDOI: 10.1016/0092-8674(94)90006-X
30 Dec 1994-Cell
Abstract: Peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers. Transcriptional activation by PPAR gamma 2 is potentiated by a variety of lipids and lipid-like compounds, including naturally occurring polyunsaturated fatty acids. We demonstrate here that retroviral expression of PPAR gamma 2 stimulates adipose differentiation of cultured fibroblasts. PPAR activators promote the differentiation of PPAR gamma 2-expressing cells in a dose-dependent manner. C/EBP alpha, a second transcription factor induced during adipocyte differentiation, can cooperate with PPAR gamma 2 to stimulate the adipocyte program dramatically. Our results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism. more

3,313 Citations

No. of papers in the topic in previous years

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Topic's top 5 most impactful authors

Kenneth R. Feingold

46 papers, 5.6K citations

Zhi Luo

40 papers, 553 citations

John L. Harwood

39 papers, 1.9K citations

Bart Staels

29 papers, 3.4K citations

David Kritchevsky

20 papers, 1.3K citations

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