Topic
Lipid peroxide
About: Lipid peroxide is a research topic. Over the lifetime, 4639 publications have been published within this topic receiving 172564 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
24,847 citations
TL;DR: This chapter discusses microsomal lipid peroxidation, a complex process known to occur in both plants and animals that involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids.
Abstract: Publisher Summary This chapter discusses microsomal lipid peroxidation Lipid peroxidation is a complex process known to occur in both plants and animals It involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids, producing a variety of breakdown products, including alcohols, ketones, aldehydes, and ethers Biological membranes are often rich in unsaturated fatty acids and bathed in an oxygen-rich, metal-containing fluid Lipid peroxidation begins with the abstraction of a hydrogen atom from an unsaturated fatty acid, resulting in the formation of a lipid radical The formation of lipid endoperoxides in unsaturated fatty acids containing at least 3 methylene interrupted double bonds can lead to the formation of malondialdehyde as a breakdown product Nonenzymic peroxidation of microsomal membranes also occurs and is probably mediated in part by endogenous hemoproteins and transition metals The direct measurement of lipid hydroperoxides has an advantage over the thiobarbituric acid assay in that it permits a more accurate comparison of lipid peroxide levels in dissimilar lipid membranes
11,945 citations
TL;DR: It is concluded that the conjugate acid of peroxynitrite, peroxlynitrous acid (ONOOH), and/or its decomposition products, i.e., .OH and nitrogen dioxide (.NO2), initiate lipid peroxidation without the requirement of iron.
2,201 citations
TL;DR: The average values determined by the new method increased slightly with age in healthy subjects, and in patients with sequelae of cerebrovascular disorders, serum lipid peroxide values were higher than in healthy controls.
1,810 citations
TL;DR: A method to determine the lipid peroxide level in human serum or plasma and its profile of change in several human diseases is described and Intervention of lipid peroxides in the pathogenesis of certain diseases is also mentioned.
1,313 citations