About: Lipoflavonoid is a(n) research topic. Over the lifetime, 2 publication(s) have been published within this topic receiving 9 citation(s).
TL;DR: The patient was prescribed a regimen of intravenous histamine, diphenhydramine (Benadryl) hydrochloride, and a nutritional supplement (Lipoflavonoid) and continued to complain of fullness in the right ear, tinnitus, and diminished hearing.
Abstract: SINCE Aug 7, 1961, a total of 243 primary operations involving endolymphatic subarachnoid shunt have been performed. The following report of a case represents an unusual complication following this procedure. Report of Case A 54-year-old diabetic man was seen in October 1963. He presented with a two-month history of tinnitus, fullness, and fluctuating hearing loss in the right ear. He also complained of intermittent positional vertigo of many years' duration. Audiograms showed a low-tone loss in the right ear. His Short Increment Sensitivity Index (SISI) score was 0% at a frequency of 4,000. Petrous pyramid x-rays were interpreted as normal. Caloric responses were normal. The patient was prescribed a regimen of intravenous histamine, diphenhydramine (Benadryl) hydrochloride, and a nutritional supplement (Lipoflavonoid). He continued to complain of fullness in the right ear, tinnitus, and diminished hearing. Dizziness and nausea occurred almost daily. Because of his failure to respond to the
TL;DR: It was not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.
Abstract: BACKGROUND Several tinnitus sufferers suggest that manganese has been helpful with their tinnitus. PURPOSE We tested this in a controlled experiment where participants were committed to taking manganese and Lipoflavonoid Plus(®) to treat their tinnitus. RESEARCH DESIGN Randomized controlled trial. STUDY SAMPLE 40 participants were randomized to receive both manganese and Lipoflavonoid Plus(®) for 6 months, or Lipoflavonoid Plus(®) only (as the control). DATA COLLECTION AND ANALYSIS Pre- and postmeasures were obtained with the Tinnitus Handicap Questionnaire, Tinnitus Primary Functions Questionnaire, and tinnitus loudness and annoyance ratings. An audiologist performed the audiogram, the tinnitus loudness match, and minimal masking level. RESULTS Twelve participants were dropped out of the study because of the side effects or were lost to follow-up. In the manganese group, 1 participant (out of 12) showed a decrease in the questionnaires, and another showed a decrease in the loudness and annoyance ratings. No participants from the control group (total 16) showed a decrease in the questionnaires ratings. Two participants in the control group reported a loudness decrement and one reported an annoyance decrement. CONCLUSIONS We were not able to conclude that either manganese or Lipoflavonoid Plus(®) is an effective treatment for tinnitus.
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