Showing papers on "Liquid paraffin published in 1988"

Ion concentrations in subcutaneous interstitial fluid: measured versus expected values

Abstract: Electrolyte concentration values in interstitial fluid samples that have been reported by a number of authors were markedly different from those of a hypothetical ultrafiltrate of plasma. Because no adequate explanation has been provided for the discrepancy, we attempted to study the question 1) by measuring ion and protein concentration in the plasma and in the interstitial fluid samples, and 2) by constructing a theoretical model for ion distribution. Subcutaneous interstitial fluid samples were collected in rats by the implanted capsule and by the liquid paraffin cavity techniques. The samples were analyzed for sodium, potassium, calcium, chloride, total protein, and protein fractions. The ion distribution between vascular and interstitial compartments was found to correspond to the Donnan equilibrium. On theoretical ground it was concluded: the Donnan distribution is valid, if the size of "free-fluid spaces" is relatively large (r greater than 0.03 micron) compared with the rather short range of electrostatic interactions (approximately 0.8 nm). Due to the relatively small difference in protein concentrations between blood plasma and interstitial fluid and to the short range of electrostatic interactions, the influence of proteins on the distribution of small ions is negligible.

Storage stable and room temperature-curable organopolysiloxane composition

Abstract: A room temperature-curable organopolysiloxane composition is proposed which is useful as a material for imprinting or blocking of forms of, for example, medical and dental prostheses without the problem of curing retardation or incomplete curing. The composition comprises a vinyl-containing organopolysiloxane, organohydrogenpolysiloxane, platinum catalyst, inorganic filler, liquid paraffin or petrolatum and antioxidant. The antioxidant serves to protect the liquid paraffin or petrolatum from oxidation to produce oxidized compounds which may deactivate the platinum catalyst to cause curing retardation or incomplete curing.

Simultaneous observation of organized density structures and the visible field in pool fires

Abstract: Organized density structures and the visible field of pool fires were observed simultaneously with a real-time holographic interferometric method. The pool diameters d varied between 1≦d≦10 cm and the fuels studied were methane, LNG, n-butane, n-pentane, n-hexane, n-heptane, diesel/gasoline, liquid paraffin; methanol, ethanol, propanol, cyclohexanol, glycerin; acetaldehyde, acetone, diethyl ether; acetic acid, methyl acetate; benzene. The organized structures depend on the height x above the pool rim, the pool diameter, the fuel supply rate, the equivalence ratio and the fuel type. These structures show mono-, quasi- and nonperiodic behaviour. In the height region Δx1=0 to 8 cm above the fuel surface of an n-hexane pool fire, d=4.6cm, six monoperiodic subprocesses exist with one independent frequency of 3 Hz and two harmonics of 9 and 12 Hz. The independent frequencies of the first quasiperiodic process are 12, 39 and 41 Hz in the height region Δx2=8 to 16 cm. The second quasiperiodic process with the two independent frequencies of 107 and 78 Hz occurs in the height region Δx3=16 to 24 cm. A third quasiperiodic process with at least the two independent frequencies of 177 Hz and 192 Hz exists in the height region Δx4=24 to 32 cm. For the mean frequencies f of the monoperiodic subprocesses the correlation f ¯ ( d ) = b ¯ D B ( d ) d − 0.5 ≈ 1.83 d − 0.63 , (2.0≦d≦2500 cm) is derived, based on the buoyant acceleration bDB of density parcels. A density structure forming concentric ring-shaped interference fringes is defined as a density parcel. With a simplified momentum equation the axial convection velocity of fire parcels, which is up to three times faster than that of the density parcels, was calculated. Instantaneous mass densities and temperatures were calculated by the Abel-inversion, including the concentration profiles of 15 stable fire gas species. From the frequency distributions of the geometric dimensions of density parcels macro-and microscales, which agree with the scales obtained from power spectra, were determined.

Etofenamate-containing adhesive tape

Abstract: An adhesive tape usable as an analgesic and antiinflammatory agent and a method of producing the same are provided. The adhesive tape comprises a support member and an adhesive mass spread on the support member, which mass contains, as essential components, etofenamate as the active ingredient, a styrene-isoprene-styrene block copolymer as an adhesive ingredient, a tackifier resin, liquid paraffin as a softening agent, a liquid rubber as a softening agent and further an antioxidant.

Micraemulsion Formation in Two-phase Region

Abstract: We prepared a thermodynamically unstable microemulsions in which a droplet does not change in size for over one year. The phase diagram showed these microemulsions to exist in the two-phase region. These microemulsions may be regarded as microemulsions in a broad sense by Rosano. They were obtained by the rapid cooling of the homogeneous phase in nonionic surfactant-oil-water systems, to room temperature. The droplet mean radius was related to the ratio of oil to surfactant by a linear function. The droplet size of these microemulsions can thus be controlled by changing this ratio.The stability of the microemulsions depends on the nature of the oil and surfactant. The stability rises dramatically with increase in the carbon number of the oil. The droplet having liquid paraffin (Lp) or squalane (Sq) undergoes no appreciable change in size for over a year at 25°C.Small quantities of Lp or Sq increase the stability of the unstable microemulsions containing a short chain hydrocarbon oii, The stability of the microemulsions increases with the size of the surfactant molecule. The main cause of instability in such systems thus appears to be related to Ostwald ripening rather than droplet coalescence.

Conformation of brain proteolipid apoprotein. Effects of sonication and n-octyl-β-D-glucopyranoside detergent

Abstract: The conformation of brain proteolipid apoprotein (PLA) has been investigated using infrared spectroscopy and freeze-fracture electron microscopy. For this purpose, spectroscopic samples consisting of a mixture of liquid paraffin and wet protein have been prepared. These systems have allowed us to record the infrared spectra of PLA at neutral pH. The amide I and III regions reveal the existence of a predominantly α-helical structure, as well as the presence of minor β-strands and random coil forms. The effect of sonication and a non-denaturing detergent, (n-octyl-β-d-glucopyranoside), on the structure of the protein have also been investigated. Sonication produces an increase of the β and unordered structures at the expense of the α-helical conformation. These structural changes are enhanced in the presence of the non-ionic detergent n-octyl-β-d-glucopyranoside. Lipids protect the native protein structure from the effects of sonication. The aforementioned detergent changes the PLA conformation by increasing the α-helical content at the expense of β-sheet and random coil forms. Therefore the PLA structure seems to be similar to the structures of other proteins intrinsic to non-neural membranes. The effects investigated also suggest that PLA behaves in a conformationally flexible manner.

O/w type multiphase emulsion and preparation thereof

Abstract: PURPOSE: To control mobility of contained oils in an O/W type multiphase emulsion having expanded field of application by forming plural kinds of O/W type emulsions by dispersing and emulsifying ≥2 kinds of oil in an aq. continuous phase independently, then mixing the O/W type emulsions to obtain the O/W type multiphase emulsion. CONSTITUTION: In the first stage, an oil phase selected appropriately from liquid paraffin, silicone oil, etc., is mixed under stirring with an aq. phase and a surface active agent to form plural kinds of O/W type emulsions. In the second stage, the plural O/W type emulsions obtd. in the first stage are simply mixed under stirring with each other to form an O/W type multiphase emulsion. In this stage, a water-soluble polymer such as alginic acid, polyvinyl alcohol, etc., is added to the aq. phase, wherein the amt. of the water-soluble polymer to be added is regulated to 0.05-10wt.% basing on the weight of a final product. Thus, the mobility of oil contained in the dispersoid is controlled by fixing the water-soluble polymer with a water-soluble polymer. COPYRIGHT: (C)1990,JPO&Japio

Biopharmaceutical Evaluation of Sustained-Release Ethylcellulose Microcapsules Containing Cefadroxil and Cephradine Using Beagle Dogs

Abstract: Two cephem antibiotics, cefadroxil and cephradine, were microencapsulated with ethyl cellulose using a solvent evaporation process in liquid paraffin containing sorbitan tristearate as a dispersing agent. These products were administered to beagle dogs and biopharmaceutical evaluations were made of the sustained-release effect. First, Vallner's method was employed for the assessment of the sustained-release ethylcellulose microcapsules. The controlled release effectiveness was close to 0.8 for ethylcellulose microcapsules containing 70% cefadroxil and 60% cephradine. Second, assessments were made using pharmacokinetic parameters based on a model allowing for the gastric-emptying and intestinal transit rates of the drug itself and the solid state drug contained in the microcapsules using nonlinear least-squares regression. The results obtained showed that transfer of the rate-limiting step to the release process from the absorption process could be observed in microcapsules containing 70% cefadroxil but not in the case of microcapsules containing 60% cephradine. The release rates calculated on the basis of the above model correlated well with the release rate in dissolution tests at pH 6.8. Finally, a new nomogram was introduced for the design of sustained-release formulaitons in the future.

Vessel lid with heat resistant liner and production thereof

Abstract: PURPOSE: To withstand a heat-charge of the contents and a heat-sterilization after charging and sealing and prevent the contents from leaking caused by a thermal deformation or a thermal constriction, by making a liner include a specified volume of extremely low melt index hydrogenated styrene/butadiene block copolymer, liquid paraffin and propylene resin. CONSTITUTION: In this vessel lid with liner, the liner includes such ingredients as follows; (i) 10-60wt.% of hydrogenated styrene/butadiene block copolymer with less melt index (200°C, 5kg) than 0.1g/10min. (ii) 20-80wt.% of liquid paraffin (iii) 5-60wt.% of propylene resin. The liner having less ingredients than the above-mentioned range (i) is poor in liner properties such as buffer actions and seal-abilities and also heat resistant properties. In case of less ingredients than the range (ii), it results in insufficient flexibilities and rubber elasticities, on the other hand, in case of much ingredients than the range (ii), it results in degraded mechanical properties and heat resistant properties. When the gradients are less than the above (iii) range, it results in bad fusion molding operation condition. A volume more than the range causes the liner properties to degrade. COPYRIGHT: (C)1990,JPO&Japio

Releasable sheet material soluble in cold water

Abstract: PURPOSE:To obtain a cold water-soluble releasable sheet material having acid resistance, alkali resistance, improved cold water solubility and releasability, by applying or adding an oily substance for releasing or a nonionic surface active agent to a specific PVA derivative. CONSTITUTION:A PVA derivative which consists of a vinyl alcohol unit,a vinyl acetate unit and an acetalized vinyl alcohol unit, has 200-500 viscosity-average polymerization degree based on vinyl monomer unit, comprises 70-90mol% vinyl alcohol unit and 0-2mol% vinyl acetate unit, has 10-30% acetalization degree and an average alkyl chain length of R of acetalized vinyl alcohol unit shown by the formula (R is alkyl) of number of carbons of 0.34-1.70 is coated or blended with an oily substance (preferably liquid paraffin, etc.) and/or a nonionic surface active agent to give a cold water-soluble releasable sheet material. USE:A water-soluble release paper for adhesive of sanitary napkin.

Production of compressed body of metal powder

Abstract: PURPOSE:To permit production of a high-density compressed body of metal powder by utilizing a pressure medium of specific fluid or solid thereby exerting an impact pressure uniformly on powders of various metals and alloys or powder mixture composed of ceramics and metals at the time of compressing said powders or powder mixture by explosive impact force of an explosive compd. CONSTITUTION:The powder 4 to be compressed consisting of the powders of the various metals and alloys or the powder mixture composed of the ceramics and metals is packed into an inside pipe 3 of a device consisting of metallic cylinders including an outside pipe 1, a middle pipe 2 and an inside pipe 3. Plugs 5, 6 made of mild steel are attached to both ends. This inside pipe 3 is erected in the middle pipe 2 and the fluid such as liquid paraffin or the solids of rubber, solder or low melting point soft metal such as lead is disposed as the pressure medium 7 into the spacing therebetween. This middle pipe 2 is erected in the outside pipe 1 and the explosives 9 of ammonium nitrate is packed into the spacing therebetween and is exploded by an electric detonator 10 to exert the explosive power of the explosives 9 uniformly to the powder 4 to be compressed via the pressure medium 7. The high-density compressed body is thus produced.

Production Method of Porous Silica Compacts Containing Submicron Pores

Abstract: The production technique of porous compacts of ceramics containing fine pores have been developed. The mixtures of silica ultrafine particles (pre-treated with solvents) and liquid paraffin were pressed under 300kg/cm2 and then fired at 800°-920°C, and the characteristics of the compacts obtained were measured. Mixtures of ultrafine silica which was pretreated by colloidal solution of silica and liquid paraffin of large quantities gave porous compacts containing fine pores. Better results were obtained when 1-18% colloidal silica was added in pre-treatment and the firing temperature was about 850°C. Apparent porosity was 60-80% for the obtained compacts. The mean pore diameter was 0.04μm for the compacts fired at 800°C, which remained virtually with increasing firing temperature, but decreased with increasing content of colloidal silica. Specific surface area was 130m2/g for the compacts fired at 850°C, and decreased with an increase both in temperature and content of colloidal silica, respectively.

Stencil printing ink

Abstract: PURPOSE:To obtain a heat-sensitive stencil printing ink capable of giving clear printed image free from squeeze-out, blur and set-off, by incorporating a nonvolatile oil dispersed with coloring agent, emulsifying agent and water with an oxycarboxylic acid-based compound. CONSTITUTION:The objective ink can be obtained by incorporating (A) an ink prepared by dispersing, in a nonvolatile or sparingly volatile oil (e.g. liquid paraffin, spindle oil,light oil, kerosene), at least colorant (e.g. carbon black), emulsifying agent (e.g. sorbitan fatty acid ester) and water with (B) pref. 5-20wt% of an oxycarboxylic acid-based compound (e.g. alpha-oxy-n-butyric acid).

Flat membrane with protrusion and manufacture thereof

Abstract: PURPOSE:To obtain a flat membrane capable of simplifying an assembling process of a filter module, and then of miniaturizing the module, and furthermore, of feasible formation of a stable flow path at the time of liquid treatment by forming fine protrusions at least on one side surface of the flat membrane. CONSTITUTION:For instance, a polypropylene, liquid paraffin as an organic filler and a crystalline nucleus forming agent are melted, blended and pelletized. These pellets are melted and extruded in a flat film form from a T die 3. This uncoagulated film 4 is allowed to pass between two molding rolls 5a, 5b with semi-spheric dents provided at uniform interval on the surface area of the roll. Then the membrane is guided into a cooling solidification liquid 7, and further, an organic filler is extracted and removed with an extracting liquid 9 to obtain a flat membrane 1 with microprotrusions 2. This membrane needs no spacer when it is assembled into a module, so that the module can be miniaturized without lowering of processing capability. If this membrane is used for blood treatment, a coagulating factor in blood caused by contacting blood with the spacer is not activated.

Fabrication Method of Porous Alumina Compacts Containing Submicron Pores

Abstract: The purpose of the present investigation was to establish the production technique of porous compacts of ceramics containing fine pores. Alumina powders of various particle sizes blended with solvent were pressed under 300kg/cm2 and then fired at 1000°-1375°C, and the characteristics of the obtained compacts were measured. Combination of ultrafine alumina having primary particle diameter of 20nm with liquid paraffin (viscosity at 40°C was 14 cSt, quantity was 3.5 times of the true volume of alumina) gave highly porous compacts containing fine pores. However the ultrafine alumina powder had to be pretreated by water to prevent cracking in firing. Porosity and specific surface area were 78% and 53m2/g, respectively, for the compact fired at 1000°C, and 66% and 6m2/g for that at 1350°C. Pore diameter in the compacts fired at 1000° and 1350°C were less than 12μm and distributed having peaks at 0.03 and 0.26μm, respectively.

Special stains in cytology: A technique using one half of a previously stained slide

Abstract: We describe a technique for performing special stains on one half of a slide previously stained by the Papanicolaou or Diff-Quick method. The technique varies depending on whether incubation is required during the staining procedure. For stains that do not require incubation, the portion of the slide to be preserved is covered with liquid paraffin. For stains that do require incubation, the area to be preserved is coverslipped with mounting medium and dried overnight prior to staining. The technique is easy, rapid, inexpensive, and enhances diagnostic accuracy.

Thin film of liquid crystal

Abstract: PURPOSE: To facilitate the formation of a thin film of a liquid crystal which is excellent in mechanical strengths by filling the pores of a specified solid polymeric porous film with a liquid crystal substance CONSTITUTION: 1-15wt% polymeric material (a), desirably a polyolefin of a weight-average MW ≥5×10 5 is dissolved by heating in a solvent (b) (eg liquid paraffin) and then formed into a sheet, which is rapidly cooled into a gel-like sheet The gel-like sheet is treated with a volatile solvent (c) (eg methylene chloride) to decrease the amount of component (b) in the sheet to 10-90wt%, heated to a temperature below the melting point of component (a) and oriented in an areal ratio ≥10 to obtain an oriented film The oriented film is treated with component (c) to extract component (b) from the film and dried to obtain a solid polymeric porous film (A) of a thickness of 01-25μm, a porosity of 40-90%, a breaking strength ≥200kg/cm 2 and an average throughhole diameter of 0001-01μm The pores of component A are filled with a liquid crystal substance (B), desirably a thermotropic liquid crystal by, for example, immersing component A in a solution of component B in a solvent (C) and evaporating component C from the treated component A COPYRIGHT: (C)1990,JPO&Japio

Coating wall and spraying material having mildewproofing and antibacterial performance

Abstract: PURPOSE:To enable a coating wall or spraying material having excellent germicidal action or antibacterial action against various bacteria and mold (Eumycetes) and capable of retaining said action over a long period of time to be formed, by blending a cation exchanger retaining a metal ion having a germicidal action. CONSTITUTION:This coating wall material or spraying material contains a cation exchanger retaining a metal ion having a germicidal action. Pref. the cation exchanger is treated with a coating agent such as liquid paraffin, a silicone resin or a fluororesin and then used to prevent a chemical reaction between the cation exchanger and other components in the coating wall or spraying material from taking place without causing lowering the antibacterial action and the mildewproofing effect. As the metal ion having a germicidal action, one or more metal ions selected from the group consisting of silver, copper, zinc, mercury, tin, lead, zirconium, bismuth and cadmium are used.

Laser beam joining method

Abstract: PURPOSE:To obtain the fine joining strength by fitting a second member with a different melting point from a first member in a close state in a fitting hole of the first member and filling powder metal in a reservoir part formed on one member at least of both members to join these members by using a laser beam. CONSTITUTION:The first member 1 and the second member 2 with the different melting points are fitted in the close state via the fitting hole. A slurry body 5 which is formed by dispersing the powder metal in liquid paraffin is applied to the reservoir part which is obtained by forming a notched part on both the members 1 and 2. The laser beam is projected on this part to which the slurry body is applied in a spot-shape to join these members together. By this method, the fine joining strength can be obtained.

Method for the treatment of tissue samples and apparatus for carrying out the method

Abstract: Samples of human or animal tissue from which thin sections are to be made for microscopic investigations must undergo various treatment steps, inter alia fixation in a liquid fixing solution and, after previous removal of water, impregnation with paraffin which has been liquefied by heating. To intensify and shorten the treatment process, the tissue samples are introduced into a treatment vessel which can be closed pressure-tight and is partly filled with the treatment liquid, i.e. with fixing solution or liquid paraffin, and which is then closed pressure-tight. Then, for a preset treatment period, pressure pulsations are generated inside the treatment vessel at least intermittently by alternate aspiration of the air present over the treatment liquid and introduction of the surrounding atmosphere. The apparatus used for carrying out this treatment accordingly has a treatment vessel (10), which can be closed pressure-tight and whose interior is connected via a line (18) to a vacuum pump (20) which can be driven by an electric motor, for the tissue samples. At least one control valve (30) is connected to the line connecting the treatment vessel and the vacuum pump and is connected to the line or inserted into the line and can be actuated alternately by an electrical or electronic control circuit (34).

Film for skin packaging

Abstract: PURPOSE:A skin packaging, consisting of a porous film having micropores with moderate air-permeability without substantially permeating a liquid and suitably usable as a bottom base material for the skin packaging CONSTITUTION:(A) A composition prepared by blending a polyolefin resin with a filler, etc, preferably by blending and kneading 15-695wt% resin consisting essentially of a linear low-density polyethylene having 01-5g/10min melt index (MI) and 09-095 density with 30-80wt% inorganic filler and 05-5wt% at least one component selected from the group consisting of fatty acid amides, liquid paraffin and sorbitan ester based surfactants of fatty acids is pelletized and (B) then formed into a film by an inflation or T-die molding (C) The resultant film is then uniaxially or biaxially oriented at 11-5 times to produce the aimed film having micropores with several mu - tens of mu of diameter

Control of evaporation from solvent to air

Abstract: PURPOSE: To control the evaporation from a solvent to the air by providing a gas absorbing method whereby the gas from a specified water-insoluble solvent is brought into contact with a specified organic liquid or mixture of said liquid and water CONSTITUTION: A separate or mixed gas of not less than two kinds produced from aromatic solvents and ester compound solvents such as aliphatic solvents (eg, heptane) at the time of paint spraying in a booth 10, after removal of most of the paint mist thereof through a water curtain 11, is introduced from the lower part of a scrubber 20 for contact with a separate or mixed liquid of a collecting liquid (or an emulsified mixture of the collecting liquid and water), liquid paraffin, aliphatic hydrocarbons having 1×10-3×10 2 carbons and alkyl condensed polycyclic compound such as high boiling alkyl benzene or alkyl naphthalene sprayed from a showering device 21, whereby the solvents are collected by the collecting liquid, which is gathered below a booth 10 for mixing with the water curtain liquid to separate the solids therefrom through a solid separating layer 12 and then sent from a liquid storage tank 13 to the water curtain 11 and the showing device 20 COPYRIGHT: (C)1990,JPO&Japio

Transparent skin cosmetic

Abstract: PURPOSE:To obtain a transparent cosmetic, having high safety, stability with time, touch and cleansing effects, etc., by adding and blending a blend of an alkyl phosphate based activator with a large amount of a liquid oily substance in a blend of a polyhydric alcohol with water. CONSTITUTION:A transparent skin cosmetic obtained by adding and blending a blend of an alkyl phosphate based nonionic activator, e.g. a compound expressed by formula I, and/or alkyl phosphate based anionic activator, e.g. a compound expressed by formula II (R1-R3 are ethylene group or propylene group (R4-R6 are 8-22C alkyl or alkenyl; l, m and n are 0-30) in an amount of 0.5-10% based on the weight of the final composition with a liquid oily substance, e.g. liquid paraffin, squalane or oleic acid, in an amount of 40-90% based on the weight of the final composition in a blend of a polyhydric alcohol in an amount of 5-59% based on the weight of the final composition (in an amount of >=4 times based on the weight of water) with water in an amount of 0.5-15% based on the weight of the final composition while stirring. The cosmetic is extremely useful as a gelatinous cleansing cream, nourishing oil, etc., which can be washed away.

Method of treating surface of molded product of vulcanized rubber

Abstract: PURPOSE:To lower the friction of a vulcanized molded product of a sulfur- vulcanizable rubber and to make it non-tacky, by treating said molded product with S dispersed in an aliph. hydrocarbon inert to rubber. CONSTITUTION:100-50,000ppm (in terms of S) of sulfur (-donating compd.) (e.g., tetramethylthiuram sulfide) is dispersed in an aliph. hydrocarbon inert to a sulfur-crosslinkable synthetic or natural rubber (e.g., liquid paraffin) to obtain a sulfur dispersion. A vulcanized molded product of this rubber is immersed in the sulfur dispersion and heated at 50-200 deg.C for 5min-48hr. If desired, the product is degreased with an aliph. hydrocarbon, washed and air-dried for 12-24hr.

Powder for preventing makeup disorder

Abstract: PURPOSE:To obtain powder, containing powdery metallic soap, cosmetic powder and preferably further oily ingredient and capable of preventing makeup disorder by applying onto the cosmetics, e.g. foundation, makeup powder, etc. CONSTITUTION:The titled powder containing 25-50wt% powdery metallic soap, e.g. Ca alkyl phosphate, 42-75wt% cosmetic powder, e.g. talc, mica, kaolin or titanium oxide, and preferably further <=8wt% oily ingredient, e.g. silicone oil or liquid paraffin. The powder is capable of completely preventing makeup disorder of an O/W type emulsion system or water dispersion system cosmetic caused by sweat. Since high adhesive property and water repellency are imparted, cosmetics are resistant to water from the outside, e.g. swimming, etc. Furthermore, since the usage is simple and the powder can be reapplied when placed in an environment likely to upset makeup.

Anti-inflammatory analgesic agent for external use

Abstract: PURPOSE:To obtain an anti-inflammatory analgesic agent for external use free from systemic side effects such as gastrointestinal disorder, by using 2-(2- fluoro-4-biphenylyl)propionic acid as an active component and combining the compound with an oleophilic base. CONSTITUTION:2-(2-Fluoro-4-biphenylyl)propionic acid of formula is used as an active component and is compounded with an oleophilic base such as petrolatum, liquid paraffin, natural rubber, synthetic rubber and polybutene. Preferably, the active component is used in combination with a transcutaneous absorbefacient (e.g. terpene such as peppermint oil and eucalyptus oil or higher fatty acid ester such as isopropyl myristate). The absorption of the active compound through the skin can be improved by the use of the transcutaneous absorbefacient. When the agent is used in the form of ointment, plaster, solution, etc., the drug is continuously released from the agent, absorbed through the skin in high efficiency and selectively transferred to the inflamed site to exhibit the activity.

2-(alkylcyclohexyl)-1-propanals and perfume composition containing the compound

Abstract: NEW MATERIAL:Compounds represented by formula I (R 1 and R 2 are H or alkyl where the total number of C is 3-7 or R 1 and R 2 form six-membered ring together with two C on cyclohexane ring). EXAMPLE: 2-(2- or 4-t-Butylcyclohexyl)-1-propanal. USE: A component of a perfume composition. Having excellent fragrances such as green-like, wood-like, flower-like, grass-like, orris-like, spice-like, grapefruit- like, amber-like or mint-like one, used as a material for preparation of a perfume and capable of blending in perfumes, soaps, shampoos, house perfumes, detergents, etc. PREPARATION: The objective compound of formula I is readily obtained by heating a 2-(alkylcyclohexyl)-1-propanol of formula II in the presence of a dehydrogenation catalyst such as Cu-Cr catalyst in a solvent such as liquid paraffin or by reacting the 2-(alkylcyclohexyl)-1-propanol with an oxidizing agent such as pyridinium chlorochromate in an organic solvent such as methylene chloride. COPYRIGHT: (C)1990,JPO&Japio