Liquid paraffin

About: Liquid paraffin is a research topic. Over the lifetime, 6185 publications have been published within this topic receiving 52956 citations.

Sublimation type thermal transfer material

Abstract: PURPOSE: To stabilize running properties without generating delamination or the lowering of sensitivity by providing a gradient to the content of the substance having lubricity or releasability in a dye transfer contributing layer in the longitudinal direction thereof so that the content of the substance having lubricity or releasability in the dye transfer contributing layer becomes much in the free surface part thereof. CONSTITUTION: A gradient is provided in the content of the substance having lubricity or releasability in a dye transfer contributing layer in the longitudinal direction thereof so that the content of the substance having lubricity or releasability in the dye transfer contributing layer becomes much in the free surface part thereof as compared with the part adjacent to a dye supply layer. The thickness of the transfer contributing layer is pref. 0.1 - 2μm and the thickness of the dye supply layer is pref. 0.5 - 8μm. As an embodiment of the substance having lubricity or releasability, there are a petroleum type lubricant such as liquid paraffin, a silicone type lubricating substance, a salt of higher fatty acid or the like. The content of said substance in the dye transfer contributing layer is pref. 0 - 10wt.% in the part adjacent to the dye supply layer and 1 - 30wt.% in the free surface part. The gradient of the content of the lubricant in the dye transfer contributing layer in the longitudinal direction thereof may be linear or stepwise. COPYRIGHT: (C)1991,JPO&Japio

Floating-mucoadhesive beads of clarithromycin for the treatment of Helicobacter pylori infection.

Abstract: An objective of the present study was to develop alginate/hydroxypropyl methylcellulose (HPMC) based floating-mucoadhesive beads of clarithromycin to provide prolonged contact time of antibiotic to treat stomach ulcer. Floating-mucoadhesive beads were prepared and characterized for in vitro performance followed by investigation of ex vivo study in albino-wistar rats. Beads were prepared by ionic gelation technique where calcium chloride used as gelating agent and incorporated liquid paraffin for floating of the beads. Prepared beads were evaluated extensively for particle size, drug entrapment; swelling and surface morphology by using scanning electron microscopy. X-ray radioimaging study in rabbits, in vitro mucoadhesion using rat stomach mucosal membrane and in vitro drug release studies were carried out. Ex vivo performance of alginate-HPMC beads were studied using albino rats in comparison to simple alginate-calcium beads. Alginate-HPMC beads may be suitable floating-muco-adhesive drug delivery system for delivering clarithromycin to treat stomach ulcers.

Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

Abstract: The apoptosis-inducing capacity of S-allylcysteine (SAC), a water-soluble garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch (HBP) carcinogenesis was investigated in male Syrian hamsters using DNA fragmentation and the apoptosis-associated proteins, tissue transglutaminase (tTG) and Bcl-2. Hamsters were divided into four groups of six animals each. Animals in group 1 were painted with a 0.5% solution of DMBA in liquid paraffin on the right buccal pouches three times a week for 14 weeks. Group 2 animals painted with DMBA as in group 1, in addition received 200 mg kg−1 body weight SAC orally on days alternate to DMBA application. Group 3 animals received SAC as in group 2. Group 4 animals received neither DMBA nor SAC and served as the control. The experiment was terminated at the end of 14 weeks. Administration of SAC (200 mg kg−1 body weight) to animals painted with DMBA inhibited DMBA-induced HBP carcinogenesis as revealed by the absence of neoplasms, induction of tTG and inhibition of Bcl-2 expression. The results of the present study suggest that SAC may exert its chemopreventive effect by inducing apoptosis. Copyright © 2002 John Wiley & Sons, Ltd.

Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin.

Abstract: The use of Eudragit L100, a copolymer based on methacrylic acid and methacrylic acid methyl ester, in preparing erythromycin microspheres is described. The microspheres were simply prepared in liquid paraffin by solidifying an Eudragit L100 in ethanol solution. When gelatin was incorporated in the solidifying solution, the resultant microspheres were more spherical and had a smooth surface. The size of the microspheres could be controlled by varying the Eudragit L100 concentration in ethanol, and erythromycin was incorporated with 60-70% efficiency. The degradation of erythromycin by acid was markedly protected when the erythromycin microspheres were coated with the polymer. The in vitro release rate of erythromycin from the microspheres was also modified by the coating process. The feasibility of preparing formulations of erythromycin for oral administration, which release the drug at a controlled rate, and protect the drug from gastric acid, is thus demonstrated.