Topic
Liquid paraffin
About: Liquid paraffin is a research topic. Over the lifetime, 6185 publications have been published within this topic receiving 52956 citations.
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TL;DR: In this article, the authors have irradiated thin gelatin films (thickness 0.5-1.0 mm) with cobalt-60 γ-rays at a dose-rate of 4.2 × 104 r.
Abstract: WE have irradiated thin gelatin films (thickness 0.5–1.0 mm.) with cobalt-60 γ-rays at a dose-rate of 4.2 × 104 r. hr.−1 at 10° C. The film was either suspended in a stoppered bottle containing oxygen or nitrogen or immersed in a liquid which filled the bottle. After irradiation of the film, attempts were made to dissolve it in 19 times its own weight of water at 40° C., and the viscosity of any resultant solution was measured. No increase in relative viscosity was observed when the irradiation was carried out in an atmosphere of oxygen or nitrogen, or when the film was suspended in liquid paraffin, benzene, ether, cyclohexanone, pyridine, acetone or an alcohol, even when the dose exceeded 1 mega-roentgen. In the presence of water, however, the gelatin became cross-linked, as was shown by the fact that it was merely swollen by treatment with boiling water.
23 citations
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TL;DR: Results show that TiO2 microtubes with an appropriate thickness exhibit enhanced light scattering effect, UV-vis light-harvesting ability, charge separation efficiency, and photocatalytic performance, and suggest that this work provides an ideal strategy for adjusting the wall thickness ofTiO2microtubes and new approach to enhance the photocatalyst performance of TiO1.
23 citations
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TL;DR: In a fire-eater who aspirated liquid paraffin during his flame-blowing show, he was admitted to the hospital with productive cough, fever, hemoptysis, chest pain and dyspnea and was diagnosed with acute exogenous lipoid pneumonia.
Abstract: BACKGROUND: Exogenous lipoid pneumonia is an uncommon condition caused by inhalation or aspiration of a fatty substance. It usually presents as chronic respiratory illness mimicking interstitial lung diseases. Acute exogenous lipoid pneumonia is uncommon and typically is caused by an episode of aspiration of a large quantity of a petroleum-based product. Radiological findings vary and may imitate many other diseases. CASE REPORT: We present a rare case of acute exogenous lipoid pneumonia in a fire-eater who aspirated liquid paraffin during his flame-blowing show (fire-eater's lung). He was admitted to the hospital with productive cough, fever, hemoptysis, chest pain and dyspnea. Diagnosis was made on the basis of history of exposure to fatty substance, characteristic findings in CT examination and presence of lipid-laden macrophages in bronchoalveolar lavage fluid. CONCLUSIONS: Acute exogenous lipoid pneumonia is a very rare disease that typically occurs in fire-eaters and is called a fire-eater's lung. The diagnosis is made on the basis of typical history and radiological, as well as histopathological findings. Language: en
23 citations
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TL;DR: Full factorial design and in vitro taste assessment approach, coupled together, was successfully applied to develop and optimize batches of ONS incorporated taste-masked microspheres.
Abstract: Context: Masking the bitter taste of Ondansetron hydrochloride (ONS) may improve palatability, acceptance and compliance of ONS products.Objective: ONS-loaded, taste-masked microspheres were prepared with a polycationic pH-sensitive polymer and 32 full factorial design (FFD) was applied to optimize microsphere batches.Materials and methods: Solvent evaporation, in acetone--methanol/liquid paraffin system, was used to prepare taste-masked ONS microspheres. The effect of varying drug/polymer (D/P) ratios on microspheres characteristics were studied by 32 FFD. Desirability function was used to search the optimum formulation. Microspheres were evaluated by FTIR, XRD and DSC to examine interaction and effect of microencapsulation process. In vitro taste assessment approach based on bitterness threshold and drug release was used to assess bitterness scores.Results: Prepared ONS microspheres were spherical and surface was wrinkled. ONS was molecularly dispersed in microspheres without any incompatibility...
23 citations
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TL;DR: The ratio of polymer to drug and the volume of polymer solvent were found to be the key factors affecting the release profile which could lead to microspheres with desired release behavior.
Abstract: The aim was to prepare theophylline-loaded Eudragit RS 100 microsphere to achieve sustained release pattern with relatively high production yield. To this end, microspheres were prepared by oil/oil solvent evaporation method using an acetone-methanol mixture and liquid paraffin system containing aluminum tristearate. Drug release profiles were determined at pH 1.2 and 7.4. Morphology and solid state of microspheres were examined using SEM, DSC, X-ray powder diffraction (XRPD), and FT-IR. As the ratio of acetone/methanol increased during the preparation of microspheres the size of microsphere was reduced. The highest drug loading efficiency (87.21%) was obtained for the microsphere containing a high ratio of polymer to drug (6:1) and high volume of acetone. SEM studies showed that the microspheres are almost spherical with a few pores and cracks at surfaces. The FT-IR, XRPD and DSC results ruled out any chemical interaction between theophylline and Eudragit. The microspheres prepared with low ratio of polymer to drug (1:2) showed faster dissolution rate than those with high polymer to drug ratio. The ratio of polymer to drug and the volume of polymer solvent were found to be the key factors affecting the release profile which could lead to microspheres with desired release behavior.
23 citations