Liquid paraffin

About: Liquid paraffin is a research topic. Over the lifetime, 6185 publications have been published within this topic receiving 52956 citations.

[60]fullerene and its use to maintain good health and to prolong the expected lifespan of mammals

Abstract: A water-insoluble fullerene is at least partially dissolved in a biocompatible lipid carrier, especially a fat or an oil such as butter, olive oil, and liquid paraffin. When administered to mammals, the fullerene, most preferably [60]fullerene dissolved in olive oil, scavenges free radicals and prolongs life span in rats.

The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats

Abstract: The liver is a major parenchymal organ involved in many functional activities in the body. Hepatic encephalopathy is a syndrome characterized by increased blood ammonia level and is one of the major complications of cirrhosis. In the present study the protective effect of HD-03, a poly-herbal formulation, was evaluated against CCl4-induced hepatic encephalopathy in rats. Hepatic encephalopathy was induced in Wistar rats by administration of CCl4 at a dose of 1 mL/kg orally in liquid paraffin (1:1) twice a week for 90 days. The liver enzymes (SGPT and SGOT) and blood ammonia levels were significantly (p < 0.001) higher in the CCl4-intoxicated group compared with the untreated control group. Administration of HD-03 at a dose of 750 mg/kg orally as an aqueous suspension significantly prevented the elevation of SGPT, SGOT and blood ammonia levels. Histomorphometric evaluation of liver and brain showed a protective effect of the HD-03 treatment, thus correlating with the changes in biochemical profiles. The protective effect of HD-03 against CCl4-induced encephalopathy may be due to the improved hepatocellular function, which in turn helps in regulating the metabolism of ammonia. However, further studies are required to measure the activity of enzymes involved in the urea cycle and brain aromatic amino acids in order to elucidate the exact mechanism of action of HD-03.

Effect of Some Levels of Cardamom, Clove and Anise on Hepatotoxicity in Rats Caused by CCL 4

Abstract: The aim of this study was to investigate the effect of three levels of cardamom, clove and anise on rats suffering from hepatotoxicity. Fifty five male albino rats (Sprague Dawley Strain) used in this study, the rats divided into eleven groups. The first and second groups fed on basal diet as a control negative and positive groups. The third, fourth and fifth groups were fed on basal diet containing (2%, 4% and 6% cardamom, respectively), the sixth, seventh and eighth groups were fed on basal diet containing (2%, 4% and 6% clove, respectively), the ninth, tenth and eleventh groups were fed on basal diet containing (2%, 4% and 6% anise, respectively). On the 27 day of the experiment, all animals, except the negative control group was administered subcutaneous injection 20% CCl in liquid paraffin oil at a dose 5 ml/kg body weight to induce 4 hepatotoxicity in rats. During the experimental period (28 days), the diets consumed and body weights were recorded twice weekly, at the end of the experiment period, the rats were fasted overnight, then the rats were anaesthetized and sacrificed and the blood samples were collected from the aorta. The blood samples were centrifuged and serum was separated to determine some biochemical parameters. Results showed that, feeding rats on basal diet and injected with CCl (control positive group) induced non-significant changes in 4 fed intake and body weight gain %, while liver and kidney weights, liver enzymes, lipid profile, except HDL-c, glucose and kidney functions increased significantly increase p?0.5, as compared to the rats fed on basal diet in the first main group (control negative group). Treating rats which suffer from hepatotoxicity with the three levels from (cardamom, clove and anise) decreased body weight gain%, liver and kidney weights/body weight%, serum AST, ALT, ALP, cholesterol, triglycerides, LDL-c, VLDL-c, uric acid, urea nitrogen, creatinine, glucose, while HDL-c increased. The highest improvement in these parameters recorded for the group which treated with the high level of clove (6%). In conclusion, the results of this study demonstrate that clove, cardamom and anise increased antioxidant activity and improved hepatotoxicity of rats.

Sensitization and Antibody Formation in Monkeys Injected with Tubercle Bacilli in Paraffin Oil

Abstract: Coulaud (1) has shown that the addition of paraffin to heat-killed tubercle bacilli promotes the sensitization of rabbits to tuberculin. Saenz (2) found that the solid paraffin could be replaced by liquid paraffin oil. He produced very intense and lasting sensitization in guinea pigs by subcutaneous or intramuscular injections of 1 cubic centimeter of paraffin oil containing a large amount of heat-killed and dried tubercle bacilli. Freund, Casals and Hosmer (3) observed that, both in the guinea pig and the rabbit, the addition of small amounts of paraffin oil to heat-killed tubercle bacilli augmented not only sensitization but also the formation of complement-fixing antibodies. The purpose of the present work was to determine whether paraffin oil containing heat-killed tubercle bacilli effectively sensitizes Macacus rhesus monkeys, a species said to be lacking in the capacity to develop cutaneous sensitization to tuberculin.