Topic
Liquid paraffin
About: Liquid paraffin is a research topic. Over the lifetime, 6185 publications have been published within this topic receiving 52956 citations.
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TL;DR: Magnetic attapulgite/fly ash/poly(acrylic acid-co-acrylamide) (ATP/FA/Poly(AA-Co-AM)) ternary nanocomposite microgels were designed via an inverse suspension copolymerization of acrylic acid (AA) and acrylamides (AM) in liquid paraffin with span-80 as stabilizer.
42 citations
TL;DR: In this article, the synthesis and characterization of poly(oxy-2,6-naphthalenediylcarbonyl) (PON) whiskers from 2-acetoxy-6naphthoic acid are described.
42 citations
TL;DR: The efficacy of this formulation on pot-grown bracken was relatively low, with 27.9% necrosis observed after 28 days, due to the particularly high resistance to fungal attack of thisBracken, however, the potential has been shown and it may be useful for other weeds and their respective mycoherbicide agents.
42 citations
TL;DR: The aim of the present study was to produce an effective drug-loaded dosage form that is able to control the release of hydroxyzine hydrochloride into the skin.
Abstract: Hydroxyzine HCl is used in oral formulations for the treatment of urticaria and atopic dermatitis. Dizziness, blurred vision, and anticholinergic responses, represent the most common side effects. It has been shown that controlled release of the drug from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the aim of the present study was to produce an effective drug-loaded dosage form that is able to control the release of hydroxyzine hydrochloride into the skin. The Microsponge Delivery System is a unique technology for the controlled release of topical agents, and it consists of porous polymeric microspheres, typically 10–50 μm in diameter, loaded with active agents. Eudragit RS-100 microsponges of the drug were prepared by the oil in an oil emulsion solvent diffusion method using acetone as dispersing solvent and liquid paraffin as the continuous medium. Magnesium stearate was added to the dispersed phase to prevent flocculation of Eudragit RS-100 microsponges. Pore inducers such as sucrose and pregelatinized starch were used to enhance the rate of drug release. Microsponges of nearly 98% encapsulation efficiency and 60–70% porosity were produced. The pharmacodynamic effect of the chosen preparation was tested on the shaved back of histamine-sensitized rabbits. Histopathological studies were driven for the detection of the healing of inflamed tissues.
42 citations
TL;DR: It is surmised that the high transition temperature of the H1+O phase and the presence of a bicontinuous cubic phase (V1) might hamper the formation of a gel-emulsion.
Abstract: The formation, stability, and rheological behavior of a hexagonal phase based gel-emulsion (O/H1 gel-emulsion) have been studied in water/C12EO8/hydrocarbon oil systems. A partial phase behavior study indicates that the oil nature has no effect on the phase sequences in the ternary phase diagram of water/C12EO8/oil systems but the domain size of the phases or the oil solubilization capacity considerably changes with oil nature. Excess oil is in equilibrium with the hexagonal phase (H1) in the ternary phase diagram in the H1+O region. The O/H1 gel-emulsion was prepared (formation) and kept at 25 degrees C to check stability. It has been found that the formation and stability of the O/H1 gel-emulsion depends on the oil nature. After 2 min observation (formation), the results show that short chain linear hydrocarbon oils (heptane, octane) are more apt to form a O/H1 gel-emulsion compared to long chain linear hydrocarbon oils (tetradecane, hexadecane), though the stability is not good enough in either system, that is, oil separates within 24 h. Nevertheless, the formation and stability of the O/H1 gel-emulsion is appreciably increased in squalane and liquid paraffin. It is surmised that the high transition temperature of the H1+O phase and the presence of a bicontinuous cubic phase (V1) might hamper the formation of a gel-emulsion. It has been pointed out that the solubilization of oil in the H1 phase could be related to emulsion stability. On the other hand, the oil nature has little or no effect on the formation and stability of a cubic phase based gel-emulsion (O/I1 gel-emulsion). From rheological measurements, it has found that the rheogram of the O/H1 gel-emulsion indicates gel-type structure and shows shear thinning behavior similar to the case of the O/I1 gel-emulsion. Rheological data infer that the O/I1 gel-emulsion is more viscous than the O/H1 gel-emulsion at room temperature but the O/H1 gel-emulsion shows consistency at elevated temperature.
42 citations