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Low protein

About: Low protein is a research topic. Over the lifetime, 8139 publications have been published within this topic receiving 213225 citations.


Papers
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Journal ArticleDOI
TL;DR: Cellular studies and clinical data suggest a direct link between survivin expression and tumour cell susceptibility to taxol, and indirectly supported by similar observations obtained with clinical tumours.
Abstract: Stable transfection of human ovarian carcinoma cells with survivin cDNA caused a four- to sixfold increase in cell resistance to taxotere and taxol (two-sided Student's t test, p 30% positive cells), detected by immunohistochemistry in 90/124 (73%) advanced ovarian carcinomas, were significantly associated with clinical resistance to a taxol/platinum-based regimen but unrelated to tumour shrinkage following cisplatin-including combinations (non-taxol based). In the 95 patients receiving a taxol/platinum-based regimen, survivin overexpression correlated with a lower clinical or pathologic complete remission rate than absent/low protein expression (43 vs 75%, p = 0.0058 by logistic regression adjusted for tumour stage, histological grade and p53 expression). Conversely, in the 29 cases treated with cisplatin-containing regimens (not taxol based), survivin expression was unrelated to tumour response. Cellular studies and clinical data suggest a direct link between survivin expression and tumour cell susceptibility to taxol.

278 citations

Journal ArticleDOI
TL;DR: The usage of nanoparticles, synthesized with Z. officinale extract, as vectors for the applications in drug delivery, gene delivery or as biosensors, where a direct contact with blood occurs is justified.

274 citations

Journal ArticleDOI
TL;DR: It is shown that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring, which is predominantly associated with insulin resistance.
Abstract: Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due to maternal protein restriction during gestation and lactation. Rat mothers were fed diets containing either 20% or 8% protein and all offspring weaned onto a standard rat diet. In old-age fasting plasma glucose concentrations were significantly higher in the low protein offspring: 8.4 (1.3)mmol/l v. 5.3 (1.3)mmol/l (p = 0.005), Areas under the curves were increased by 67% for glucose (p = 0.01) and 81% for insulin (p = 0.01) in these rats in intravenous glucose tolerance tests, suggesting (a degree of) insulin resistance. These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance.

273 citations

Journal ArticleDOI
TL;DR: The characterized GPP1/RHR2 and GPP2/HOR2 genes, encoding isoforms of glycerol 3-phosphatase, conclude that glycerl metabolism plays multiple roles in yeast adaptation to altered growth conditions, explaining the complex regulation of glycersol biosynthesis genes.

273 citations

Journal ArticleDOI
TL;DR: In this article, photolysis using ultraviolet light and graft polymerization of hydrophilic monomers onto the membrane surface was used to create more hyrophilic and lower fouling membrane surfaces.

273 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20227
2021298
2020300
2019278
2018308
2017306