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Low protein
About: Low protein is a research topic. Over the lifetime, 8139 publications have been published within this topic receiving 213225 citations.
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TL;DR: It is suggested that the diminution of enzyme velocities for the low protein group is related both to a lower DNA content per gram tissue and to a loss of specific enzymic activity per milligram microsomal protein.
Abstract: The effect of protein deficiency in male weanling rats on the activity of the hepatic microsomal enzyme system was studied. Animals were divided into three groups and were fed for 15 days either a semipurified diet con taining 5% casein (group 1), 20% casein pair-fed to the 5% casein group (group 2) or 20% casein fed ad libitum (group 3). The liver weight, as a per centage of body weight, was higher in group 1. For group 1 animals, microsomal protein and DNA, when expressed per gram of liver, were approximately one-half the contents of groups 2 and 3. Maximal velocities for ethylmorphine (EM) and aniline (AN) were lower in group 1, whether these rates are expressed per milli gram microsomal protein, per gram liver or per 100 g body weight. A comparison of these methods of expression suggested that the diminution of enzyme velocities for the low protein group is related both to a lower DNA content per gram tissue and to a loss of specific enzymic activity per milligram microsomal protein. The Kmfor ethylmorphine was lower and that for aniline was higher in group 1 ani mals. Restriction of food intake affected enzyme kinetic parameters similar to protein deficiency but to a significantly lesser degree. Alternative explanations for this effect of protein deficiency are discussed and an involvement of phospho- lipid is suggested. J. Nutr. 102: 53-60, 1972.
73 citations
TL;DR: The F GF21-dependent increase in UCP1 and energy expenditure by LP has no effect on the ability to acutely respond to cold stress, suggesting that LP-induced increases in FGF21 impact metabolic but not thermogenic endpoints.
Abstract: Dietary protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food intake, and these effects require the metabolic hormone fibroblast growth factor 21 (FGF21). Here we test whether the induction of energy expenditure during protein restriction requires UCP1, promotes a resistance to cold stress, and is dependent on the concomitant hyperphagia. Wildtype, Ucp1-KO and Fgf21-KO mice were placed on control and low protein (LP) diets to assess changes in energy expenditure, food intake and other metabolic endpoints. Deletion of Ucp1 blocked LP-induced increases in energy expenditure and food intake, and exacerbated LP-induced weight loss. While LP diet increased energy expenditure and Ucp1 expression in an FGF21-dependent manner, neither LP diet nor the deletion of Fgf21 influenced sensitivity to acute cold stress. Finally, LP-induced energy expenditure occurred even in the absence of hyperphagia. Increased energy expenditure is a primary metabolic effect of dietary protein restriction, and requires both UCP1 and FGF21 but is independent of changes in food intake. However, the FGF21-dependent increase in UCP1 and energy expenditure by LP has no effect on the ability to acutely respond to cold stress, suggesting that LP-induced increases in FGF21 impact metabolic but not thermogenic endpoints.
73 citations
Patent•
09 Jan 1985
TL;DR: In this article, a method for stabilizing human gamma globulin (IgG) preparations with histidine-stabilized immunoglobulin (HGI) is described.
Abstract: Histidine-stabilized immunoglobulin preparations and a method for their manufacture are disclosed. The present invention is particularly well suited for stabilization of human gamma globulin (IgG) preparations having a relatively low protein content. Preferred stabilized human gamma globulin preparations comprise about 5 wt-% or less gamma globulin, histidine at a concentration of about 0.025M to about 0.2M, and optionally glycine at a concentration of about 0.05M to about 0.5M. The pH value of the preparations is at least 6.0 but not more than 7.0. A pH value of about 6.4 is most preferred. Conductivity of the preparations is about 2 to about 4 millisiemens at 5° C., preferably about 2.5 to about 3.5 millisiemens at 5° C., and most preferably about 2.7 millisiemens at 5° C.
73 citations
TL;DR: Patterns of consumption in both experiments were consistent with the control of food choices and intake being governed by a combination of known mechanisms, including direct metabolic feedback and learning.
73 citations
TL;DR: Induction of ketosis may be a novel strategy to safely and effectively treat status in adults even after weeks to months of refractory seizures, although there are few data regarding the use of the ketogenic diet in the treatment of adult epilepsy syndromes.
Abstract: Prolonged status epilepticus (SE) can be refractory to conventional interventions, with high rates of subsequent morbidity and mortality. A high fat, low protein, low carbohydrate ketogenic diet (KD) has been used successfully to treat intractable epilepsy. However, its possible role in prolonged SE has not been well described. We report successful use of the KD in two adult patients with prolonged nonconvulsive SE (NCSE) refractory to multiple other interventions. Our observations suggest induction of ketosis may be a novel strategy to safely and effectively treat status in adults even after weeks to months of refractory seizures. Although there are few data regarding the use of the ketogenic diet in the treatment of adult epilepsy syndromes, it may be an option for the treatment of adults with refractory, prolonged SE.
73 citations