Topic
Low protein
About: Low protein is a research topic. Over the lifetime, 8139 publications have been published within this topic receiving 213225 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The β-chitin with long chains and high purity is suitable for producing high quantity β- chitosan for various potential applications.
72 citations
TL;DR: Observations indicate a leptin-independent stimulation of the orexigenic ARC-PVN axis in undernourished LP rats at weaning and a disturbed NPYergic regulation of the VMN is suggested, possibly contributing to alterations of the hypothalamic regulation of body weight and metabolism in LP offspring during life.
72 citations
TL;DR: The ideal drug for older patients would be effective, without neurological toxicity, with low protein binding, a nonparticipant in drug interactions and amenable to once daily administration, but comparative trials of anticonvulsants in the elderly are needed.
Abstract: Seizures are extremely common in the elderly, with an annual incidence reaching 100 per 100000 people aged over 60 years. Most are precipitated by acute symptomatic illnesses such as stroke or systemic disease. Chronic neurological diseases such as Alzheimer's disease may also cause seizures. The aetiology of seizures in many patients is unknown. Seizures may be situational and subside quickly, but the prevalence of chronic seizures--epilepsy--is as high as 1% in the elderly. The majority of seizures are of partial onset, especially complex partial. Complex partial seizures at this age may be very subtle and hard to diagnose. Generalised-onset seizures also occur, perhaps as a result of diffuse changes with aging or degenerative disease or to a combination of genetic and environmental factors. The prognosis for complete seizure control in this population is relatively favourable. Physiological and disease-related changes with aging result in complex pharmacokinetics. Most changes lead to a need for gentler drug treatment with cautious initiation of drugs at lower dosages. Consideration must be given to renal and hepatic function, protein binding and drug interactions. Determinations of free (unbound) drug concentrations are helpful for highly protein bound drugs. The dosages of newer drugs excreted renally must be adjusted based on creatinine clearance. The dosage of most drugs is determined empirically by careful observation of seizure control and adverse effects. Carbamazepine, valproic acid (sodium valproate), gabapentin and lamotrigine have certain theoretical advantages, but comparative trials of anticonvulsants in the elderly are needed. The ideal drug for older patients would be effective, without neurological toxicity, with low protein binding, a nonparticipant in drug interactions and amenable to once daily administration.
72 citations
TL;DR: Viscosity determinations, both on native sputum and on reconstituted human alpha-acid glycoprotein, indicate that either raising or reducing the pH from neutral results in an increase in viscosity.
72 citations
TL;DR: In this article, the authors found specific correlations between dietary protein, amino acids, and increasing environmental temperatures for broilers, and fed a series of 3250 kcal ME grower diets with increasing protein levels, or low protein diets with 90, 100, or 110% NRC recommended levels of methionine, lysine, tryptophan, Arginine, and threonine.
Abstract: This study sought to determine specific correlations between dietary protein, amino acids, and increasing environmental temperatures for broilers. Male broilers were house in six different constant environmental temperatures ranging from 21.1 to 35°C and fed a series of 3250 kcal ME grower diets with increasing protein levels, or low protein diets with 90, 100, or 110% NRC recommended levels of methionine, lysine, tryptophan, Arginine, and threonine. The broilers house in temperatures below 25.3°C showed increased weight gains with increased CP diets, whereas birds house in temperatures greater than 26.7°C showed depressed gain with CP diets greater than 20%. Broilers fed the 16 and 18% diets did not show increased gains with the five added essential amino acids under any temperature conditions, indicating that other amino acids were limiting.
72 citations