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Low protein

About: Low protein is a research topic. Over the lifetime, 8139 publications have been published within this topic receiving 213225 citations.


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Journal ArticleDOI
TL;DR: XRCC1 and pol β expression status in BRCA1 negative tumours may have prognostic significance and be targeted by ATM or DNA‐PKcs inhibitors for personalized therapy.

65 citations

Journal ArticleDOI
TL;DR: Farmers can use the mixed feeding schedule of alternate day feeding of LP and HP as a means of reducing feed costs for profitable sutchi catfish culture with silver carp by demonstrating that feeding fish continuously with HP is less economical.
Abstract: A 6-month feeding trial was conducted in field condition using 10 farm ponds (400–600 m2) to investigate the effect of mixed feeding schedules on the growth of sutchi catfish, Pangasius hypophthalmus with silver carp, Hypophthalmichthys molitrix. Fish were stocked at a ratio of 80:20 (sutchi catfish, 4.9±0.5 g: silver carp, 12.0±0.8 g) at the total rate of 25 000 ha−1. Two diets of high protein (30%, HP) and low protein (16%, LP) were prepared using locally available feed ingredients. Five different feeding schedules of high-protein diet continuously (HP), low-protein diet continuously (LP), 1-day low–protein/1-day high-protein diet (1LP/1HP), 7 days low–protein/7 days high-protein diet (7LP/7HP) and 14 days low–protein/14 days high-protein diet (14LP/14HP) were tested. The fish were fed twice daily at the rate of 15%, 10%, 8% and 5% of their body weight for first, second, third month and rest of experimental period respectively. Feeding rate was calculated only on the basis of sutchi catfish weight only and was adjusted every 2 weeks according to weight gain. Fish fed LP and HP on alternate day (1LP/1HP) resulted in significantly (P 0.05) between the growth rates and production of fish fed HP regularly and fish fed 7 days LP followed by 7 days HP (7LP/7HP). Fish maintained on LP grew the least. The feed conversion ratio (FCR) values for sutchi catfish ranged between 2.04 and 2.79 with feeding schedule 1LP/1HP showing the best FCR. The total production of fish (including silver carp) ranged between 8310 and 12 422 kg ha−1 6 months−1 with 1LP/1HP feeding schedule resulting in the highest production and net profit. The study demonstrated that feeding fish continuously with HP is less economical. Thus, for profitable sutchi catfish culture with silver carp, farmers can use the mixed feeding schedule of alternate day feeding of LP and HP as a means of reducing feed costs.

65 citations

Journal ArticleDOI
TL;DR: The results of this meta-analysis are consistent with a role for protein Z deficiency in thrombotic diseases, including arterialThrombosis, pregnancy complications and venous thromboembolism.
Abstract: The relationship between protein Z levels and thrombosis is controversial. We performed a systematic review and meta-analysis of the available studies to assess the association between protein Z and vascular thrombotic diseases. We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, The Cochrane Library, bibliographies of retrieved articles and abstracts of congresses up to October, 2009. Studies were included if they analysed protein Z levels in patients with vascular thrombotic diseases. After the review process, 28 case-control studies (33 patient cohorts), including 4,218 patients with thrombotic diseases and 4,778 controls, were selected for analysis. The overall analysis using a random-effects model showed that low protein Z levels were associated with an increased risk of thrombosis (odds ratio [OR] 2.90, 95% confidence interval [CI] 2.05–4.12; p<0.00001). On subgroup analysis, a significant association was found between low protein Z levels and arterial vascular diseases (OR 2.67, 95%CI 1.60–4.48; p=0.0002), pregnancy complications (OR 4.17, 95%CI 2.31–7.52; p<0.00001), and venous thromboembolic diseases (OR 2.18, 95%CI 1.19–4.00; p=0.01). The results of this meta-analysis are consistent with a role for protein Z deficiency in thrombotic diseases, including arterial thrombosis, pregnancy complications and venous thromboembolism.

65 citations

Journal ArticleDOI
TL;DR: The uptake kinetics indicate that a saturable component predominates at low protein concentrations, but a non-saturable component is the major uptake route at higher concentrations, which suggests that BSA is pinocytosed probably bound to the membrane and dissolved in the bulk solvent phase.
Abstract: Preimplantation mouse embryos take up whole 125I-labelled BSA from their environment. In blastocysts this uptake was temperature-sensitive and reversibly inhibited by trypan blue: properties consistent with an endocytotic mechanism. The uptake kinetics indicate that a saturable component predominates at low protein concentrations, but a non-saturable component is the major uptake route at higher concentrations. This suggests that BSA is pinocytosed probably bound to the membrane and dissolved in the bulk solvent phase. The rate of uptake, equivalent to about 5 pl/min/blastocyst was similar to that reported for non-saturable glycine uptake. In blastocysts the protein is degraded to acid-soluble products. At reported genital tract fluid protein concentrations this would represent a significant contribution to the embryonic pool of fixed nitrogen.

65 citations

Journal ArticleDOI
TL;DR: Two charge variants of the protein have been identified on native polyacrylamide gels, indicating that modification of the amino terminus of this protein can occur after cleavage of the signal peptide in the periplasm.

65 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20227
2021298
2020300
2019278
2018308
2017306