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Low protein

About: Low protein is a research topic. Over the lifetime, 8139 publications have been published within this topic receiving 213225 citations.


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Journal ArticleDOI
TL;DR: The data support the view that increased globule leukocyte counts and plasma IgE anti-L3 antibody may be associated with nutritionally improved expression of immunity in periparturient ewes, and suggest that changes in mucosal mast cell and eosinophil counts are not necessarily associated with changes in host resistance to T. circumcincta.

65 citations

Journal ArticleDOI
TL;DR: GPC analysis suggested that both the concentration and molecular weight distribution of the macromolecules in supernatant play an important role in gel layer formation and loss of membrane porosity.

65 citations

Journal ArticleDOI
TL;DR: It is determined that low protein synthesis within hematopoietic stem cells (HSCs) is associated with elevated proteome quality in vivo, and Aarssti/sti mice that harbor a tRNA editing defect that increases amino acid misincorporation are examined.

65 citations

Journal ArticleDOI
09 Aug 2019-Cancers
TL;DR: The current knowledge about PTEN status in lung cancer is discussed, highlighting the prevalence of its alterations in the disease, the regulatory mechanisms and the implications of PTEN on available treatment options.
Abstract: Lung cancer is the most common malignancy and cause of cancer deaths worldwide, owing to the dismal prognosis for most affected patients. Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) acts as a powerful tumor suppressor gene and even partial reduction of its levels increases cancer susceptibility. While the most validated anti-oncogenic duty of PTEN is the negative regulation of the PI3K/mTOR/Akt oncogenic signaling pathway, further tumor suppressor functions, such as chromosomal integrity and DNA repair have been reported. PTEN protein loss is a frequent event in lung cancer, but genetic alterations are not equally detected. It has been demonstrated that its expression is regulated at multiple genetic and epigenetic levels and deeper delineation of these mechanisms might provide fertile ground for upgrading lung cancer therapeutics. Today, PTEN expression is usually determined by immunohistochemistry and low protein levels have been associated with decreased survival in lung cancer. Moreover, available data involve PTEN mutations and loss of activity with resistance to targeted treatments and immunotherapy. This review discusses the current knowledge about PTEN status in lung cancer, highlighting the prevalence of its alterations in the disease, the regulatory mechanisms and the implications of PTEN on available treatment options.

65 citations

Journal ArticleDOI
TL;DR: In this article, the best use can be made of alpha-linolenic acid, lignans and soluble fibre from flaxseed, by studying flax seed and flax-seed cake as sources of compounds of interest for food industry.
Abstract: Flax (Linum usitatissimum) has been used for centuries as a source for oil extraction. In recent years it has attracted considerable interest as a result of studies which attribute potential health benefits to its components, including the prevention of chronic non-communicable diseases. Among these compounds presenting biological activity, alpha-linolenic acid, lignans and soluble fibre are of special interest. Southern Chile has comparative advantages for the cultivation of this crop. Together with its full processing, this crop could strengthen regional industry. The purpose of the present work is to learn how the best use can be made of these compounds, by studying flaxseed and flaxseed cake as sources of compounds of interest for food industry. Oil extracted from flaxseed contained 51.86% of linolenic, 16.34% of linoleic and 20.98% of oleic acid. Fractioning of defatted flaxseed cake produced a polyphenol content of 0.73 mg GAEg-1 extract and a protein isolate of considerable purity, 53.15% yield with 0.78 gof albumin equivalent g-1 protein isolate. Additionally, a polysaccharide was isolated with low protein content as impurity, 10.71% yield with 1.37 mg of glucose equivalent per gram of polysaccharide. This information will form the basis for assessing the extraction of products of interest for the food industry from flaxseed cake.

65 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20227
2021298
2020300
2019278
2018308
2017306