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About: Malaria is a(n) research topic. Over the lifetime, 37074 publication(s) have been published within this topic receiving 914099 citation(s). The topic is also known as: Plasmodium infection & induced malaria. more


Open access
01 Jan 2005-
Topics: Malaria (68%), Indoor residual spraying (55%)

4,964 Citations

Open accessJournal ArticleDOI: 10.1128/CMR.11.3.480
Duane J. Gubler1Institutions (1)
Abstract: Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever. more

Topics: 2009 Bolivian dengue fever epidemic (75%), Dengue vaccine (71%), Dengue fever (71%) more

3,706 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE03342
10 Mar 2005-Nature
Abstract: Interest in mapping the global distribution of malaria is motivated by a need to define populations at risk for appropriate resource allocation and to provide a robust framework for evaluating its global economic impact. Comparison of older and more recent malaria maps shows how the disease has been geographically restricted, but it remains entrenched in poor areas of the world with climates suitable for transmission. Here we provide an empirical approach to estimating the number of clinical events caused by Plasmodium falciparum worldwide, by using a combination of epidemiological, geographical and demographic data. We estimate that there were 515 (range 300-660) million episodes of clinical P. falciparum malaria in 2002. These global estimates are up to 50% higher than those reported by the World Health Organization (WHO) and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries. Without an informed understanding of the cartography of malaria risk, the global extent of clinical disease caused by P. falciparum will continue to be underestimated. more

Topics: Malaria (57%), Plasmodium falciparum (50%)

2,765 Citations

Journal ArticleDOI: 10.1038/415680A
07 Feb 2002-Nature
Abstract: Where malaria prospers most, human societies have prospered least. The global distribution of per-capita gross domestic product shows a striking correlation between malaria and poverty, and malaria-endemic countries also have lower rates of economic growth. There are multiple channels by which malaria impedes development, including effects on fertility, population growth, saving and investment, worker productivity, absenteeism, premature mortality and medical costs. more

Topics: Malaria (55%), Poverty (52%), Population growth (51%) more

2,229 Citations

Open accessJournal ArticleDOI: 10.5582/BST.2020.01047
Jianjun Gao1, Zhenxue Tian, Xu YangInstitutions (1)
16 Mar 2020-BioScience Trends
Abstract: The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future. more

Topics: Pneumonia (59%), Chloroquine Phosphate (56%), Malaria (51%)

1,886 Citations

No. of papers in the topic in previous years

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Topic's top 5 most impactful authors

Nicholas J. White

367 papers, 34.1K citations

Brian Greenwood

283 papers, 27.7K citations

Robert W. Snow

218 papers, 29.7K citations

Kevin Marsh

215 papers, 26K citations

François Nosten

184 papers, 18.2K citations

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