Topic
Mammography
About: Mammography is a research topic. Over the lifetime, 20643 publications have been published within this topic receiving 513679 citations.
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TL;DR: PEM and MR imaging had comparable breast-level sensitivity, although MR Imaging had greater lesion- level sensitivity and more accurately depicted the need for mastectomy.
Abstract: Overall, 61 (16%) of 388 participants had an appropriate change in surgical management based on MR findings—more than the 41 (11%) participants with an appropriate change based on positron emission mammography (PEM) findings (P = .003) and fewer than the 71 (18%) participants with an appropriate change based on combined PEM and MR findings (P = .004 for comparison with MR imaging alone); 25 (6.4%) women had excessive excisions on the basis of MR findings compared with 19 (4.9%) women who had them on the basis of PEM findings (P = .26) and 32 (8.2%) women who had them after undergoing combined PEM and MR imaging (P = .023 for comparison with MR imaging alone).
168 citations
TL;DR: It is concluded that mammography screening programmes implemented for at least 10 years achieve a similar, but not greater mortality reduction as the randomised controlled trials.
168 citations
TL;DR: This study used large-scale mammography screening trial data to deduce the growth law of primary breast cancer, and showed that the data are inconsistent with the exponential, logistic and Gompertz laws, but support power law growth.
Abstract: Despite considerable progress in understanding tumour development, the law of growth for human tumours is still a matter of some dispute. In this study, we used large-scale mammography screening trial data to deduce the growth law of primary breast cancer. We compared the empirical tumour population size distributions of primary breast cancer inferred from these data to the distributions that correspond to various possible theoretical growth functions. From this, we showed that the data are inconsistent with the exponential, logistic and Gompertz laws, but support power law growth (exponent approximately 0.5). This law indicates unbounded growth but with slowing mass-specific growth rate and doubling time. In the clinical size ranges, it implies a greater decline in the mass-specific growth rate than would be predicted by the Gompertz law using the accepted parameters. This suggests that large tumours would be less sensitive to cycle-specific therapies, and be better treated first by non-cell cycle-specific agents. We discussed the use of our study to estimate the sensitivity of mammography for the detection of small tumours. For example, we estimated that mammography is about 30% less sensitive in the detection of tumours in the 1 to 1.5-cm range than it is in detecting larger tumours.
167 citations
167 citations
TL;DR: MRI of the breast can identify occult breast cancer in many patients and may facilitate breast conservation in select women, and negative breast MRI predicts low tumor yield at mastectomy.
Abstract: Introduction: Occult primary breast cancer, i.e., isolated axillary adenocarcinoma without detectable tumor in the breast by either physical exam or mammography, represents up to 1% of operable breast cancer. Modified radical mastectomy (MRM) is generally the accepted treatment for this condition although tumor is identified in only two-thirds of mastectomy specimens. Breast magnetic resonance imaging (MRI) can identify occult breast carcinoma and may direct therapy. This study examined the ability of breast MRI to detect occult breast cancer and to facilitate breast conservation therapy.
167 citations