Topic
Marrubium peregrinum
About: Marrubium peregrinum is a research topic. Over the lifetime, 12 publications have been published within this topic receiving 421 citations.
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01 Jan 2011
TL;DR: In this article, in vitro antioxidant activity, total phenolic content and concentration of flavonoids of five different extracts, from the whole herb of Marrubium peregrinum L. (Lamiaceae) were determined using spectrophotometric methods.
Abstract: In this study, in vitro antioxidant activity, total phenolic content and concentration of flavonoids of five different extracts, from the whole herb of Marrubium peregrinum L. (Lamiaceae) were determined using spectrophotometric methods. Antioxidant activity of extracts were expressed as percentage of DPPH radicals inhibition and IC50 values (μg/ml). Values in percentage ranged from 27.26 to 89.78%. The total phenolic content ranged from 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic acid equivalents. The total flavonoid concentrations varied from 18.72 to 54.77 mg/g, expressed as rutin equivalents. Methanolic exstract of M. peregrinum showed the highest phenolic and flavonoid concentration and strong antioxidant activity. The significant linear correlation was confirmed between the values for the total phenolic content and antioxidant activity of plant extracts. The high contents of phenolic compounds indicated that these compounds contribute to the antioxidant activity. The M. peregrinum can be regarded as promising candidates for natural plant sources of antioxidants with high value.
279 citations
TL;DR: The chemical composition of the essential oils obtained from the flowering aerial parts of Marrubium vulgare and marrubium peregrinum L. were determined by GC/MS as mentioned in this paper.
Abstract: The chemical composition of the essential oils obtained from the flowering aerial parts of Marrubium vulgare L.. and Marrubium peregrinum L. were determined by GC/MS. Twelve components were identified in M. vulgare oil with β-caryophyllene (45.8%) and germacrene D (14.4%) being the major constituents. In M. peregrinum oil, sixteen compounds were identified with β-caryophyllene (31.3%), germacrene D (28.1%) and bicyclogermacrene (15.3%) predominating.
40 citations
TL;DR: The antioxidant activity of Marrubium peregrinum essential oil, collected from three different locations [Backo Gradiste - Rimski Sanac (No.1), Novi Knezevac and Senta (no.3)] was evaluated as free radical scavenging capacity (RSC), together with inhibition on xanthine-oxidase and effects on lipid peroxidation (LP) as mentioned in this paper.
Abstract: The antioxidant activity of Marrubium peregrinum essential oil, collected from three different locations [Backo Gradiste - Rimski Sanac (No.1), Novi Knezevac (No.2) and Senta (No.3)] was evaluated as free radical scavenging capacity (RSC), together with inhibition on xanthine-oxidase and effects on lipid peroxidation (LP). RSC was assessed measuring the scavenging activity of the essential oils on 2,2-diphenyl-1-picrylhydrazyl (DPPH·), super oxide anion (O2·-), nitric-oxide (NO·) and hydroxyl (OH·) radicals. The activities of xanthine-oxidase (XOD) was determined by the nitrite method. Effects on LP were evaluated by following the activities of essential oils in the Fe2+/ascorbate induction system. Experimental results indicate that the essential oil of M. peregrinum from Senta (No.3) exhibited the strongest inhibitory effect, as the IC50 value was achieved with the lowest concentration. The same result was obtained in investigation of influence of essential oil on XOD and LP. The chemical profile of essential oil was evaluated by the means of gas chromatography-mass spectrometry (GC-MS). According to the analysis, the most powerful scavenging compounds were sesquiterpene hydrocarbons (b-caryophyllene, bicyclogermacrene and germacrene-D) and oxygenated sesquiterpenes (spathulenol and caryophyllene oxide).
39 citations
TL;DR: This work provides a common natural source for the hemi-synthesis of future ladanein-derived flavones and the study of their antileukemic activity.
Abstract: Three methoxylated flavones isolated from Marrubium peregrinum - ladanein, scutellarein-5,7,4'-trimethyl ether, and scutellarein-5,6,7,4'-tetramethyl ether - were assayed for their cytotoxicity towards a recently developed dasatinib-resistant murine leukemia cell line (DA1-3b/M2 (BCR-ABL)), together with the structurally related non-methylated flavone scutellarein. The most active compound, ladanein, was looked for in 20 common Lamiaceae species by a quick HPLC screening. Among the possible positive results, the most interesting source was found to be Marrubium vulgare, which led to the isolation and identification of ladanein for the first time in this species. Ladanein also displayed moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines but was toxic neither to MOLM13 nor to human peripheral blood mononuclear cells. This work provides a common natural source for the hemi-synthesis of future ladanein-derived flavones and the study of their antileukemic activity.
36 citations
TL;DR: The essential oil of Marrubium velutinum Sm, isolated in 0.02-0.04% yield, contained, as principal components, γ-muurolene, β-caryophyllene and β-carthusene oxide.
Abstract: The essential oil of Marrubium velutinum Sm., isolated in 0.02–0.04% yield, contained, as principal components, γ-muurolene, β-caryophyllene and β-caryophyllene oxide. A significant number of sesquiterpenes were present in smaller amounts. The essential oil of Marrubium peregrinum L., obtained in 0.07% yield, contained (Z)- and (E)-β-farnesene as main compounds. Copyright © 1999 John Wiley & Sons, Ltd.
27 citations