Topic
Mechanism (sociology)
About: Mechanism (sociology) is a research topic. Over the lifetime, 32616 publications have been published within this topic receiving 212176 citations. The topic is also known as: mechanism.
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TL;DR: The concept of commitment is widely used but has received little formal analysis as mentioned in this paper, which contains an implicit explanation of one mechanism producing consistent human behavior. Commitments come into bei...
Abstract: The concept of commitment is widely used but has received little formal analysis. It contains an implicit explanation of one mechanism producing consistent human behavior. Commitments come into bei...
3,705 citations
3,136 citations
01 Jan 2000
TL;DR: The crystal structure of the catalytic domain of the Abelson tyrosine kinase (Abl) complexed to a variant of STI-571 is reported in this paper.
Abstract: The inadvertent activation of the Abelson tyrosine kinase (Abl) causes chronic myelogenous leukemia (CML). A small-molecule inhibitor of Abl (STI-571) is effective in the treatment of CML. We report the crystal structure of the catalytic domain of Abl, complexed to a variant of STI-571. Critical to the binding of STI-571 is the adoption by the kinase of an inactive conformation, in which a centrally located "activation loop" is not phosphorylated. The conformation of this loop is distinct from that in active protein kinases, as well as in the inactive form of the closely related Src kinases. These results suggest that compounds that exploit the distinctive inactivation mechanisms of individual protein kinases can achieve both high affinity and high specificity.
1,602 citations
1,441 citations