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Showing papers on "Medicinal plants published in 2022"


Journal ArticleDOI
TL;DR: Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.
Abstract: The purpose of this review is to summarize the available antidiabetic medicinal plants in the Kingdom of Saudi Arabia with its phytoconstituents and toxicological findings supporting by the latest literature. Required data about medicinal plants having antidiabetic activities and growing in the Kingdom of Saudi Arabia were searched/collected from the online databases including Wiley, Google, PubMed, Google Scholar, ScienceDirect, and Scopus. Keywords used in search are in vivo antidiabetic activities, flora of Saudi Arabia, active ingredients, toxicological evaluations, and medicinal plants. A total of 50 plant species belonging to 27 families were found in the flora of Saudi Arabia. Dominant family was found Lamiaceae with 5 species (highest) followed by Moraceae with 4 species. β-Amyrin, β-sitosterol, stigmasterol, oleanolic acid, ursolic acid, rutin, chlorogenic acid, quercetin, and kaempferol are the very common bioactive constituents of these selected plant species. This paper has presented a list of antidiabetic plants used in the treatment of diabetes mellitus. Bioactive antidiabetic phytoconstituents which showed that these plants have hypoglycemic effects and highly recommended for further pharmacological purposes and to isolate/identify antidiabetes mellitus (anti-DM) active agents also need to investigate the side effects of active ingredients.

42 citations


Journal ArticleDOI
TL;DR: In this article , the authors summarized the processes of hepatotoxicity induced by various toxins and explored identified hepatoprotective plants and their phytoconstituents, which can guide the extraction of novel phytochemical constituents from plants to treat liver injury.

27 citations


Journal ArticleDOI
TL;DR: In this paper, the authors summarized the processes of hepatotoxicity induced by various toxins and explored identified hepatoprotective plants and their phytoconstituents, which can guide the extraction of novel phytochemical constituents from plants to treat liver injury.

27 citations


Journal ArticleDOI
TL;DR: In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile and the bioactive compound richness contributes to the biological activity of Senna plant extracts.
Abstract: The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

26 citations


Journal ArticleDOI
TL;DR: In this article, a comprehensive review of the traditional applications, phytochemistry, pharmacological activities, and toxicity of various extracts and isolated compounds from C. roseus is presented.

25 citations


Journal ArticleDOI
TL;DR: This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts and defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies.
Abstract: Background: Research on medicinal plants and extracts derived from them differs from studies performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or animals pose some unique challenges: they are multicomponent mixtures of active, partially active and inactive substances, and the activity is often not exerted on a single target. Their composition varies depending on the method of preparation and the plant materials used. This complexity and variability impact the reproducibility and interpretation of pharmacological, toxicological and clinical research. Objectives: This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts. The focus is on herbal extracts used in pharmacological, toxicological, and clinical/intervention research. Specifically, the consensus-based statement focuses on defining requirements for: 1) Describing the plant material/herbal substances, herbal extracts and herbal medicinal products used in these studies, and 2) Conducting and reporting the phytochemical analysis of the plant extracts used in these studies in a reproducible and transparent way. The process and methods: We developed the guidelines through the following process: 1) The distinction between the three main types of extracts (extract types A, B, and C), initially conceptualised by the lead author (MH), led the development of the project as such; 2) A survey among researchers of medicinal plants to gather global perspectives, opportunities, and overarching challenges faced in characterising medicinal plant extracts under different laboratory infrastructures. The survey responses were central to developing the guidelines and were reviewed by the core group; 3) A core group of 9 experts met monthly to develop the guidelines through a Delphi process; and. 4) The final draft guidelines, endorsed by the core group, were also distributed for feedback and approval to an extended advisory group of 20 experts, including many journal editors. Outcome: The primary outcome is the “Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts“ (ConPhyMP) which defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies. The checklist is intended to be an orientation for authors in medicinal plant research as well as peer reviewers and editors assessing such research for publication.

25 citations


Journal ArticleDOI
TL;DR: In this article , a comprehensive review of the traditional applications, phytochemistry, pharmacological activities, and toxicity of various extracts and isolated compounds from C. roseus is presented.

25 citations


Journal ArticleDOI
TL;DR: In this article , the authors summarized the complex origins of Apiaceae and the current state of research on the family, including traditional and molecular breeding practices, bioactive compounds, medicinal applications, nanotechnology and omics research.
Abstract: Many of the world’s most important vegetables and medicinal crops, including carrot, celery, coriander, fennel, and cumin, belong to the Apiaceae family. In this review, we summarize the complex origins of Apiaceae and the current state of research on the family, including traditional and molecular breeding practices, bioactive compounds, medicinal applications, nanotechnology and omics research. Numerous molecular markers, regulatory factors and functional genes have been discovered, studied and applied to improve vegetables and medicinal crops in Apiaceae. In addition, current trends in Apiaceae application and research are also briefly described, including mining new functional genes and metabolites using omics research, identifing new genetic variant associated with the important agronomic traits by population genetics analysis and GWAS, applying the genetic transformation, CRISPR-Cas9 gene editing system and nanotechnology in Apiaceae plants. This review provides a reference for basic and applied research on Apiaceae vegetable and medicinal plants.

24 citations


Journal ArticleDOI
TL;DR: In this paper , the authors systematically evaluated previously published reports on the anti-inflammatory and analgesic effects of Moroccan medicinal plants, including phenolic acids, flavonoids, and terpenoids.

23 citations


Journal ArticleDOI
TL;DR: The use of medicinal plants is common practice amongst the southern African population and may provide targets for drug development as mentioned in this paper, however, the use of non-steroidal anti-inflammatory drugs (NSAID's) is accompanied by harmful and toxic side effects.

20 citations


Journal ArticleDOI
TL;DR: A review of relevant medicinal plants is based on the fundamental knowledge accumulated by indigenous people of Ethiopia and to identify which types of selected medicinal plants for phytochemical analysis were analyzed and which one was not analyzed at Ethiopian levels as mentioned in this paper .
Abstract: Abstract Background This review of relevant medicinal plants is based on the fundamental knowledge accumulated by indigenous people of Ethiopia and to identify which types of selected medicinal plants for phytochemical analysis were analyzed and which one is not analyzed at Ethiopian levels. In this review, the most traditional medicinal plant species found and used in Ethiopia are chosen. Results The qualitative phytochemical analysis, some of which are the most important phytochemicals such as phenolic, tannins, alkaloids, saponins, cardiac glycosides, steroids, terpenoids, flavonoids, phlobatannins, anthraquinones, and reducing sugars are studied by the researcher. Most studies have revealed that some phytochemicals are present in some medicinal plants while some are absent. The phytochemical properties of some species were studied like Artemisia afra (Ariti), Aloe Vera (Erret), Yzygium guineense (Dokuma), Ruta chalepensis (Tenadam), Ocimum grattissimum (Damakese), Nigella sativa (Tikur Azmud), Lepidium sativum (Feto), Hagenia abyssinica (Kosso), Croton macrostachyus (Bisana), and Rhamnus prinoides (Gesho). Conclusions This review has shown that traditional medicinal plants whose phytochemical properties are not studied have various medicinal purposes like treating mastitis, preventing boils, hemorrhoids, congestion, headache, hepatitis, liver, vertigo, stomatitis, kidneys, liver, and vision for treating anemia, hemorrhoid coughs, fluxes, and stomatitis in most animals and human beings. So that identifying the plants based on the investigation and analysis of phytochemical properties of such plant species are more important than Ethiopian levels.

Journal ArticleDOI
TL;DR: This review article has focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes.
Abstract: Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.

Journal ArticleDOI
TL;DR: In this paper , the authors reviewed the literature on the effects of arbuscular mycorrhizal fungi (AMF) on the production of secondary metabolites in medicinal plants, and concluded that AMF impact the secondary metabolites either directly by increasing plant biomass or indirectly by stimulating secondary metabolite biosynthetic pathways.
Abstract: Medicinal plants are an important source of therapeutic compounds used in the treatment of many diseases since ancient times. Interestingly, they form associations with numerous microorganisms developing as endophytes or symbionts in different parts of the plants. Within the soil, arbuscular mycorrhizal fungi (AMF) are the most prevalent symbiotic microorganisms forming associations with more than 70% of vascular plants. In the last decade, a number of studies have reported the positive effects of AMF on improving the production and accumulation of important active compounds in medicinal plants.In this work, we reviewed the literature on the effects of AMF on the production of secondary metabolites in medicinal plants. The major findings are as follows: AMF impact the production of secondary metabolites either directly by increasing plant biomass or indirectly by stimulating secondary metabolite biosynthetic pathways. The magnitude of the impact differs depending on the plant genotype, the AMF strain, and the environmental context (e.g., light, time of harvesting). Different methods of cultivation are used for the production of secondary metabolites by medicinal plants (e.g., greenhouse, aeroponics, hydroponics, in vitro and hairy root cultures) which also are compatible with AMF. In conclusion, the inoculation of medicinal plants with AMF is a real avenue for increasing the quantity and quality of secondary metabolites of pharmacological, medical, and cosmetic interest.

Journal ArticleDOI
TL;DR: An extensive literature review was undertaken to identify southern African plants used traditionally to treat inflammation as discussed by the authors , which identified 555 medicinal plants from 118 families which were traditionally used in southern Africa to treat inflammatory and pain.

Journal ArticleDOI
TL;DR: In this paper , the authors introduced plant cell culture technologies as a viable mechanism for producing and studying secondary metabolites of medicinal plants, and these secondary metabolites are often used by plants in the various important tasks like defense against herbivory, interspecies defenses and against different types of stresses.
Abstract: Plants are the prime source of vital secondary metabolites (SMs) which are medicinally important for drug development, and these secondary metabolites are often used by plants in the various important tasks like defense against herbivory, interspecies defenses and against different types of stresses. For humans, these secondary metabolites are important as medicines, pigments, flavorings and drugs. Because most of the pharmaceutical industries are highly dependent on medicinal plants and their extraction, these medicinal plants are getting endangered.Plant cell culture technologies are introduced as a viable mechanism for producing and studying SMs of plants. Various types of in vitro strategies (elicitation, hairy root culture system, suspension culture system, etc.) have been considerably used for the improvement of the production of SMs of plants. For the enhancement of SM production, suspension culture and elicitation are mainly used, but hairy root culture and other organ cultures are proved to satisfy the demand of secondary metabolites. Now, it is easy to control and manipulate the pathways that produce the plant secondary metabolites.Techniques like plant cell, tissue and organ cultures provide a valuable method for the production of medicinally significant SMs. In recent years, most of the in vitro strategies are used due to knowledge and regulation of SM pathway in commercially valuable plants. In future, these things will provide a valuable method to sustain the feasibility of medicinal plants as the renewable sources of medicinally important compounds, and these methods will provide successful production of desired, important, valuable and also unknown compounds.

Journal ArticleDOI
TL;DR: In this paper , the authors introduced plant cell culture technologies as a viable mechanism for producing and studying secondary metabolites of medicinal plants, and these secondary metabolites are often used by plants in the various important tasks like defense against herbivory, interspecies defenses and against different types of stresses.
Abstract: Plants are the prime source of vital secondary metabolites (SMs) which are medicinally important for drug development, and these secondary metabolites are often used by plants in the various important tasks like defense against herbivory, interspecies defenses and against different types of stresses. For humans, these secondary metabolites are important as medicines, pigments, flavorings and drugs. Because most of the pharmaceutical industries are highly dependent on medicinal plants and their extraction, these medicinal plants are getting endangered.Plant cell culture technologies are introduced as a viable mechanism for producing and studying SMs of plants. Various types of in vitro strategies (elicitation, hairy root culture system, suspension culture system, etc.) have been considerably used for the improvement of the production of SMs of plants. For the enhancement of SM production, suspension culture and elicitation are mainly used, but hairy root culture and other organ cultures are proved to satisfy the demand of secondary metabolites. Now, it is easy to control and manipulate the pathways that produce the plant secondary metabolites.Techniques like plant cell, tissue and organ cultures provide a valuable method for the production of medicinally significant SMs. In recent years, most of the in vitro strategies are used due to knowledge and regulation of SM pathway in commercially valuable plants. In future, these things will provide a valuable method to sustain the feasibility of medicinal plants as the renewable sources of medicinally important compounds, and these methods will provide successful production of desired, important, valuable and also unknown compounds.

Journal ArticleDOI
TL;DR: A review of relevant medicinal plants is based on the fundamental knowledge accumulated by indigenous people of Ethiopia and to identify which types of selected medicinal plants for phytochemical analysis were analyzed and which one was not analyzed at Ethiopian levels as discussed by the authors .
Abstract: Abstract Background This review of relevant medicinal plants is based on the fundamental knowledge accumulated by indigenous people of Ethiopia and to identify which types of selected medicinal plants for phytochemical analysis were analyzed and which one is not analyzed at Ethiopian levels. In this review, the most traditional medicinal plant species found and used in Ethiopia are chosen. Results The qualitative phytochemical analysis, some of which are the most important phytochemicals such as phenolic, tannins, alkaloids, saponins, cardiac glycosides, steroids, terpenoids, flavonoids, phlobatannins, anthraquinones, and reducing sugars are studied by the researcher. Most studies have revealed that some phytochemicals are present in some medicinal plants while some are absent. The phytochemical properties of some species were studied like Artemisia afra (Ariti), Aloe Vera (Erret), Yzygium guineense (Dokuma), Ruta chalepensis (Tenadam), Ocimum grattissimum (Damakese), Nigella sativa (Tikur Azmud), Lepidium sativum (Feto), Hagenia abyssinica (Kosso), Croton macrostachyus (Bisana), and Rhamnus prinoides (Gesho). Conclusions This review has shown that traditional medicinal plants whose phytochemical properties are not studied have various medicinal purposes like treating mastitis, preventing boils, hemorrhoids, congestion, headache, hepatitis, liver, vertigo, stomatitis, kidneys, liver, and vision for treating anemia, hemorrhoid coughs, fluxes, and stomatitis in most animals and human beings. So that identifying the plants based on the investigation and analysis of phytochemical properties of such plant species are more important than Ethiopian levels.

Journal ArticleDOI
TL;DR: In this article , the authors used an insilico molecular docking approach to test whether bioactive molecules of herbal origin such as hyperoside, nimbaflavone, ursolic acid, 6-gingerol, 6shogaol and 6-paradol, curcumin, catechins and epigallocatechin, α-Hederin, piperine, and others could bind and potentially block the Mproenzyme of the SARS-CoV-2 virus.

Journal ArticleDOI
01 Aug 2022-Cancers
TL;DR: 33 medicinal plants with active and significant anticancer activity, as well as their anticancer compounds are listed to provide a basic set of information for researchers interested in developing a safe and nontoxic active medicinal plant-based treatment for cancer.
Abstract: Simple Summary Drugs are used to treat cancer. Most drugs available in the market are chemosynthetic drugs and have side effects on the patient during and after the treatment, in addition to cancer itself. For instance, hair loss, loss of skin color and texture, loss of energy, nausea, infertility, etc. To overcome these side effects, naturally obtained drugs from medicinal plants are preferred. Our review paper aims to encourage the study of anticancer medicinal plants by giving detailed information on thirty-three medicinal plants and parts that constitute the phytochemicals responsible for the treatment of cancer. The development of plant-based drugs could be a game changer in treating cancer as well as boosting the immune system. Abstract Cancer is a serious and significantly progressive disease. Next to cardiovascular disease, cancer has become the most common cause of mortality in the entire world. Several factors, such as environmental factors, habitual activities, genetic factors, etc., are responsible for cancer. Many cancer patients seek alternative and/or complementary treatments because of the high death rate linked with cancer and the adverse side effects of chemotherapy and radiation therapy. Traditional medicine has a long history that begins with the hunt for botanicals to heal various diseases, including cancer. In the traditional medicinal system, several plants used to treat diseases have many bioactive compounds with curative capability, thereby also helping in disease prevention. Plants also significantly contributed to the modern pharmaceutical industry throughout the world. In the present review, we have listed 33 medicinal plants with active and significant anticancer activity, as well as their anticancer compounds. This article will provide a basic set of information for researchers interested in developing a safe and nontoxic active medicinal plant-based treatment for cancer. The research will give a scientific foundation for the traditional usage of these medicinal herbs to treat cancer.

Journal ArticleDOI
TL;DR: This review expresses in detail the versatile uses of phytotherapies and their based nanoformulation as a promising tool for disease management in aquaculture.

Journal ArticleDOI
TL;DR: Herbal medicines are the effective source of prime components for drug detection and the formation of phytopharmaceuticals in the control of devastating parasitic infections.
Abstract: Parasitic infections are a major public health concern affecting millions of people universally. This review elaborates on the potential impacts of plants and their bioactive components that have been widely used in the cure of several parasitic infections of poultry. The medicinal importance of natural herbs depends upon their bioactive ingredients, which are originated from crude plants, consequently leading to the specific action on the body. Due to the limited availability of effective drugs and high cost, the development of drug resistance in several harmful parasites and microbes leads to huge economic losses in the poultry industry. This will impose the development of innovative sources for drugs to overwhelm the therapeutic failure. Moreover, the environment-friendly feed additives which can be applied as a substitute to antibiotic growth promoters (AGP) for broilers were proven. The application of natural products with therapeutic characteristics is an ancient practice that is appropriately gaining more acceptance. Globally, it is assessed that some 20,000 species of higher plants are used medicinally, although traditional medicine has a scarcity of knowledge on its efficiency and wellbeing. This review explores the usage of medicinal herbs for parasitic infections, emphasizing the recent knowledge available while detecting the research gaps which may be explored to find the usage of herbal medicines for parasitic infections in poultry. In conclusion, herbal medicines are the effective source of prime components for drug detection and the formation of phytopharmaceuticals in the control of devastating parasitic infections. There is a prerequisite to applying the traditional medicine information in clinical applications via value addition.

Journal ArticleDOI
TL;DR: In this article , a review of clinical studies on medicinal mushrooms or preparations derived thereof is presented, and the authors conclude that despite the promising published clinical data, especially on immune modulation, more work is required to clarify the therapeutic value of mushrooms.

Journal ArticleDOI
01 Jan 2022
TL;DR: In this paper , the authors compared the toxicity of 53 selected medicinal plants commonly used in the Philippines to treat various diseases, using the brine shrimp lethality assay (BSLA).
Abstract: The study compares the toxicity of 53 selected medicinal plants commonly used in the Philippines to treat various diseases. It uses as a benchmark Vitex negundo L., which was approved by the Philippine Food and Drug Administration as an herbal drug for cough and asthma after passing clinical trials for safety and efficacy. The methods were chosen for their simplicity and accessibility even for resource-limited laboratories. Extracts (95 % ethanol) of the medicinal parts of the plants were (1) chemically profiled using qualitative phytochemical tests that detect the presence of key classes of bioactive compounds; and (2) evaluated for toxicity using the brine shrimp (Artemia sp.) lethality assay (BSLA). General phytochemical screening revealed the presence of tannins in 50 plant extracts, alkaloids in 43, glycosides in 33, flavonoids in 31, steroids in 21, triterpenoids in 20, anthraquinones in 10, and saponins in 8. Extracts from eight plants had LC50 values lower than the potassium dichromate control (approximately 12 μg/mL) and were considered highly toxic; extracts from 21 plants had LC50 values between 12 μg/mL and 100 μg/mL and were considered moderately toxic; extracts from 19 plant extracts, including Vitex negundo and some common vegetables, had LC50 values between 100 μg/mL and 500 μg/mL, and were considered mildly toxic and likely to have reasonable safety margins; five plant extracts, including common vegetables, had LC50 values above 500 μg/mL and were considered essentially nontoxic. No apparent correlation could be found between toxicity and chemical diversity or a specific class of phytochemicals present. Our findings may serve as a guide for herbal drug and nutraceutical development, especially in prioritizing plants for more detailed safety studies.

Journal ArticleDOI
TL;DR: This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases, with aging being the most important cause.
Abstract: Diseases with a significant loss of neurons, structurally and functionally are termed as neurodegenerative diseases. Due to the present therapeutic interventions and progressive nature of diseases, a variety of side effects have risen up, thus leading the patients to go for an alternative medication. The role of medicinal plants in such cases has been beneficial because of their exhibition via different cellular and molecular mechanisms. Alleviation in inflammatory responses, suppression of the functionary aspect of pro-inflammatory cytokines like a tumor, improvement in antioxidative properties is among few neuroprotective mechanisms of traditional plants. Variation in transcription and transduction pathways play a vital role in the preventive measures of plants in such diseases. Neurodegenerative diseases are generally caused by depletion of proteins, oxidative and inflammatory stress, environmental changes and so on, with aging being the most important cause. Natural compounds can be used in order to treat neurodegenerative diseases Medicinal plants such as Ginseng, Withania somnifera, Bacopa monnieri, Ginkgo biloba, etc. are some of the medicinal plants for prevention of neurological symptoms. This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases.

Journal ArticleDOI
TL;DR: A review of 114 medicinal plant species grown in Iran were selected and their major constituents, animal or cell targets, as well as possible anticancer mechanisms, were ascertained through searching pertinent keywords in the Scientific Information Database (SID), IranMedex, PubMed, Medline, Google Scholar, Science Direct, Web of Knowledge and Scopus databases as discussed by the authors .

Journal ArticleDOI
TL;DR: In this paper , the authors presented an overview of the major neurodegenerative diseases and reported prominent medicinal plants used in managing those diseases in West Africa, and used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses to filter articles based on their relevance.

Journal ArticleDOI
TL;DR: The aim of this paper is to concisely collect information concerning the few antidiabetic or hypoglycaemic raw plant materials that are present in the consciousness of Europeans and relatively easily accessible to them on the market and sometimes even grown on European plantations.
Abstract: Diabetes is a metabolic disease that affected 9.3% of adults worldwide in 2019. Its co-occurrence is suspected to increase mortality from COVID-19. The treatment of diabetes is mainly based on the long-term use of pharmacological agents, often expensive and causing unpleasant side effects. There is an alarming increase in the number of pharmaceuticals taken in Europe. The aim of this paper is to concisely collect information concerning the few antidiabetic or hypoglycaemic raw plant materials that are present in the consciousness of Europeans and relatively easily accessible to them on the market and sometimes even grown on European plantations. The following raw materials are discussed in this mini-review: Morus alba L., Cinnamomum zeylanicum J.Presl, Trigonella foenum-graecum L., Phaseolus vulgaris L., Zingiber officinale Rosc., and Panax ginseng C.A.Meyer in terms of scientifically tested antidiabetic activity and the presence of characteristic biologically active compounds and their specific properties, including antioxidant properties. The characteristics of these raw materials are based on in vitro as well as in vivo studies: on animals and in clinical studies. In addition, for each plant, the possibility to use certain morphological elements in the light of EFSA legislation is given.


Journal ArticleDOI
09 Jan 2022-Plants
TL;DR: A rich and alive traditional knowledge concerning plants uses in the Gran Paradiso National Park is shown, which may provide new opportunities from the scientific point of view, for the valorization of local products for health community and for sustainable land management.
Abstract: Most of traditional knowledge about plants and their uses is fast disappearing because of socio-economic and land use changes. This trend is also occurring in bio-cultural refugia, such as mountain areas. New data on Traditional Ethnobotanical Knowledge (TEK) of Italian alpine regions were collected relating to three valleys (Cogne, Valsavarenche, Rhêmes) of the Gran Paradiso National Park. Extensive dialogues and semi-structured interviews with 68 native informants (30 men, 38 women; mean age 70) were carried out between 2017 and 2019. A total of 3918 reports were collected, concerning 217 taxa (including 10 mushrooms, 1 lichen) mainly used for medicinal (42%) and food (33%) purposes. Minor uses were related to liquor making (7%), domestic (7%), veterinary (5%), forage (4%), cosmetic (1%) and other (2%). Medicinal plants were used to treat 14 ailment categories, of which the most important were respiratory (22%), digestive (19%), skin (13%), musculoskeletal (10%) and genitourinary (10%) diseases. Data were also evaluated by quantitative ethnobotanical indexes. The results show a rich and alive traditional knowledge concerning plants uses in the Gran Paradiso National Park. Plants resources may provide new opportunities from the scientific point of view, for the valorization of local products for health community and for sustainable land management.

Journal ArticleDOI
TL;DR: In this article , a pure fraction named AN-10 was isolated from ethyl acetate fraction of crude methanol extract which identified as Betulin (Lupan-3ß,28-diol) by Liebermann-Burchard test and structure elucidation by UV-Vis, NMR and MS techniques.
Abstract: Abstract Medicinal plants are in use of humankind since ancient and still they are playing an important role in effective and safer natural drug delivery systems. Acacia nilotica (native of Egypt) commonly known as babul belongs to family Fabaceae, widely spread in India, Sri Lanka and Sudan. Being a common and important plant, using in many ways from fodder (shoots and leaves to animals) to dyeing (leather coloration) to medicine (root, bark, leaves, flower, gum, pods). The present study is focused on investigating the natural chemistry and important biological activities of the plant. Employing bioassay guided fractionation coupled with TLC and column chromatography, a pure fraction named AN-10 was isolated from ethyl acetate fraction of crude methanol extract which identified as “Betulin (Lupan-3ß,28-diol)” by Liebermann-Burchard test and structure elucidation by UV–Vis, NMR and MS techniques. A battery of in vitro biological assays for antioxidant, anti-inflammatory and anticancer were performed and betulin showed excellent potential in all assays. It was found that the inhibitory potential in all assays were dose dependent manner and after a range of concentration, the activities get leveled off with no further increase in activity.