Topic
Melibiose
About: Melibiose is a research topic. Over the lifetime, 1002 publications have been published within this topic receiving 27300 citations. The topic is also known as: Melibiose.
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TL;DR: The in vitro growth and sporulation of Frankia isolate HFPCcI3, a nitrogen‐fixing symbiont of Casuarina, was inhibited by both the toxic and osmotic effects of sodium chloride, suggesting that differential strain‐specific mechanisms are involved in Frankia's ability to tolerate dry versus sodic soil conditions.
Abstract: The in vitro growth and sporulation of Frankia isolate HFPCcI3, a nitrogen‐fixing symbiont of Casuarina, was inhibited by both the toxic and osmotic effects of sodium chloride. This was demonstrated by comparing HFPCcI3 halotolerance with its tolerance to metabolically neutral melibiose osmoticum at sodium chloride and melibiose concentrations from 0 to 500 mmol L‐1. The osmotolerance of this strain is similar to that of other Frankia strains, whereas the halotolerance of this strain is greater than that reported for Frankia strains isolated from actinorhizal plants from moist, temperate regions lacking sodic soils. This finding suggests that differential strain‐specific mechanisms are involved in Frankia's ability to tolerate dry versus sodic soil conditions and has important implications for the microbial ecology of soils supporting Casuarina spp. (Less)
8 citations
TL;DR: The potential of lactulose and melibiose for mitigating PD neurodegeneration is shown, offering new drug candidates for PD treatment and up-regulating autophagy and nuclear factor, erythroid 2 like 2 (NRF2) pathway in DAergic neurons derived from SH-SY5Y cells over-expressing α-synuclein.
Abstract: Parkinson's disease (PD) is a neurodegenerative disease characterized by selective dopaminergic (DAergic) neuronal degeneration in the substantia nigra (SN) and proteinaceous α-synuclein-positive Lewy bodies and Lewy neuritis. As a chemical chaperone to promote protein stability and an autophagy inducer to clear aggregate-prone proteins, a disaccharide trehalose has been reported to alleviate neurodegeneration in PD cells and mouse models. Its trehalase-indigestible analogs, lactulose and melibiose, also demonstrated potentials to reduce abnormal protein aggregation in spinocerebellar ataxia cell models. In this study, we showed the potential of lactulose and melibiose to inhibit α-synuclein aggregation using biochemical thioflavin T fluorescence, cryogenic transmission electron microscopy (cryo-TEM) and prokaryotic split Venus complementation assays. Lactulose and melibiose further reduced α-synuclein aggregation and associated oxidative stress, as well as protected cells against α-synuclein-induced neurotoxicity by up-regulating autophagy and nuclear factor, erythroid 2 like 2 (NRF2) pathway in DAergic neurons derived from SH-SY5Y cells over-expressing α-synuclein. Our findings strongly indicate the potential of lactulose and melibiose for mitigating PD neurodegeneration, offering new drug candidates for PD treatment.
7 citations
TL;DR: Insight is provided into the metabolic alterations induced by B. simplex treatment, which affects the interactions with soybean cyst nematodes and improves disease resistance.
Abstract: We aimed to profile the metabolism of soybean roots that were infected with soybean cyst nematodes and treated with Bacillus simplex to identify metabolic differences that may explain nematode resistance. Compared with control soybean roots, B. simplex-treated soybean roots contained lower levels of glucose, fructose, sucrose, and trehalose, which reduced the nematodes' food source. Furthermore, treatment with B. simplex led to higher levels of melibiose, gluconic acid, lactic acid, phytosphingosine, and noradrenaline in soybean roots, which promoted nematocidal activity. The levels of oxoproline, maltose, and galactose were lowered after B. simplex treatment, which improved disease resistance. Collectively, this study provides insight into the metabolic alterations induced by B. simplex treatment, which affects the interactions with soybean cyst nematodes.
7 citations
TL;DR: The conditions for the quantitative determination of melibiose (or raffinose after invertase hydrolysis) on paper chromatograms by either the use of “Genochrome” or N,N -diethyl- p -phenylenediamine as dip reagents were determined.
7 citations
TL;DR: A new Saccharomyces species has been isolated from ‘alpechin’ by its ability to ferment and assimilate glucose, maltose and melibiose, and can hydrolyse raffinose.
Abstract: SUMMARY: A new Saccharomyces species has been isolated from ‘alpechin’. It is distinguished from other species of the genus by its ability to ferment and assimilate glucose, maltose and melibiose. Galactose, sucrose, lactose and raffinose are not assimilated. The melibiase found in S. hienipiensis can hydrolyse raffinose.
7 citations