Topic
Melibiose
About: Melibiose is a research topic. Over the lifetime, 1002 publications have been published within this topic receiving 27300 citations. The topic is also known as: Melibiose.
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TL;DR: The msm region has been reintroduced to the deletion mutants by transformation and the ability to grow on galactose and β-glucosides was also restored, showing the linkage of the respective genes.
Abstract: The oral bacterium Streptococcus mutans possesses the ability to ferment a wide range of carbohydrates, which results in the production of acids that can cause demineralisation of tooth enamel and subsequent dental caries. However, it has been shown that approximately 11% of independent isolates of S. mutans from around the world lack the ability to ferment melibiose, raffinose, and on occasion β-glucosides (1,4). This is due to a deletion which extends through a region of the genome that includes the multiple sugar metabolism (msm) operon involved in the uptake and metabolism of a number of sugars (3). The msm region has been reintroduced to the deletion mutants by transformation and the ability to grow on galactose and β-glucosides was also restored, showing the linkage of the respective genes. The extent of the deletion is further being investigated with the use of pulsed field gel electrophoresis and Southern hybridizations with known S. mutans genes as probes.
1 citations
TL;DR: Guan et al. as mentioned in this paper used single-molecule force spectroscopy to investigate substrate-induced structural changes of MelB from Salmonella typhimurium, and showed that both substrates guide MelB transporters to populate two different mechanically stabilized states, and contribute mechanistic insights to the alternating-access action for the galactoside/cation symport catalyzed by MelB.
1 citations
TL;DR: The results indicate that IOSs induce browning and generation of the majority of the monitored odorants, in particular 4-hydroxy-2,5-dimethyl-3(2 H)-furanone, 2,3-butanedione, 2-acetyl-1-pyrroline, and 2- acetyl-2-thiazoline, far more than the other oligosaccharides and to a higher or similar degree to that of the monos
Abstract: The generation of selected Maillard-derived odorants from iso-oligosaccharides (IOSs), namely, from isomaltose, isomaltotriose, isomaltulose, and melibiose, was studied and compared with that from other oligosaccharides (maltose, lactose, and panose) and monosaccharides (glucose, galactose, and fructose). The study was carried out in binary mixtures of sugar and amino acids (glycine, proline, and cysteine) and upon wafer baking. The results indicate that IOSs induce browning and generation of the majority of the monitored odorants, in particular 4-hydroxy-2,5-dimethyl-3(2 H)-furanone, 2,3-butanedione, 2-acetyl-1-pyrroline, 2-propionyl-1-pyrroline, 2-acetylthiazole, and 2-acetyl-2-thiazoline, far more than the other oligosaccharides and to a higher or similar degree to that of the monosaccharides. Plausible mechanisms, consistent with the yields obtained from individual sugars, were proposed for the formation of the studied compounds. This newly obtained data brought for the first time evidence about the extraordinary potential of IOSs in the formation of several potent food odorants.
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TL;DR: Fructose, glucose, maltose, sucrose, and trehalose provided the strongest support for survival of adult male and infected and uninfected adult female A. aegypti and the same was true for female mosquitoes infected with D. immitis; except for melibiose which provided poor support for egg production.
1 citations
TL;DR: In this article, a preparation procedure for the synthesis of N-glycyl-β-glycopyranosylamines, derivatives of monosaccharides (d-galactose,d-mannose,l-fucose, and N-acetyl-d-glucosamine) and disaccharide derivatives (lactoses, melibiose, cellobiose and maltose) was developed.
Abstract: A convenient preparative procedure was developed for the synthesis ofN-glycyl-β-glycopyranosylamines, derivatives of monosaccharides (d-galactose,d-mannose,l-fucose, andN-acetyl-d-glucosamine) and disaccharides (lactose, melibiose, cellobiose, and maltose). These compounds were demonstrated to be useful for the preparation of glycoconjugates of biologically active compounds containing the carboxy group (nicotinic, orotic, kynurenic, and indoleacetic acids). Synthetic pathways were developed for conversions ofN-glycyl-β-glycopyranosylamines into derivatives containing the carboxy group with the use of malonic andl-tartaric acid derivatives.
1 citations