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Methacrylic acid

About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.


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Journal ArticleDOI
TL;DR: A technique for the synthesis of molecularly imprinted polymers (MIPs) in small scale coupled with direct in situ processing and batch rebinding evaluation is reported, showing the polymer showing the highest selectivity was the one prepared using methacrylic acid as functional monomer.
Abstract: A technique for the synthesis of molecularly imprinted polymers (MIPs) in small scale (∼55 mg) coupled with direct in situ processing and batch rebinding evaluation is reported. The primary assessment is based on quantification by HPLC or UV absorbance measurement of the amount of template released from the polymer in a given solvent. This method allows a rapid screening of the parameters of importance to reach a desired level of binding affinity capacity and selectivity for a given target molecule. This was demonstrated for the triazine herbicide terbutylazine, where an initial screening was performed for the type of functional monomer used in the MIP preparation. Thus among the six functional monomers tested, methyl methacrylate, 4-vinylpyridine, and N-vinyl-α-pyrrolidone led to rapid and quantitative extraction whereas methacrylic acid and (trifluoromethyl)acrylic acid led to polymers that retained the template the most. After having established useful functional monomers, a secondary screening for selectivity was performed. In this, nonimprinted blank polymers were prepared and a normal batch rebinding evaluation was performed. The polymer showing the highest selectivity was the one prepared using methacrylic acid as functional monomer. This polymer was shown to strongly retain chlorotriazines including atrazine when a normal-scale batch of the polymer was evaluated in chromatography.

180 citations

Journal ArticleDOI
TL;DR: These thermo-sensitive magnetic immunomicrospheres were effective for the immunoaffinity purification of anti-BSA antibodies from antiserum.
Abstract: Ultrafine magnetite particles were prepared by a co-precipitation method. The poly-(styrene/N- isopropylacrylamide/methacrylic acid) latex particles containing ultrafine magnetite [magnetic P(St/NIPAM/MAA)] were prepared by two-step emulsifier-free emulsion polymerization. The minimum NaCl concentration for flocculation of these magnetic latex particles (critical flocculation concentration, CFC) decreased with increasing temperature. These temperature dependence of CFC, namely its thermo-sensitivity, originated from NIPAM. At a certain NaCl concentration, some of the magnetic latex particles showed reversible transition between flocculation and dispersion by controlling the temperature, and the thermo-flocculated magnetic latex particles were separated quickly in a magnetic field. Bovine serum albumin (BSA) was covalently immobilized onto the magnetic P(St/NIPAM/MAA) latex particles with high efficiency by the carbodiimide method. These thermo-sensitive magnetic immunomicrospheres were effective for the immunoaffinity purification of anti-BSA antibodies from antiserum.

175 citations

Journal ArticleDOI
TL;DR: In this paper, a magnetic composite poly(styrene-methacrylic acid) microsphere, was prepared using oleic acid-coated magnetic nanoparticles as seeds by microemulsion copolymerization of styrene (St) and methacric acid (MAA), and the lipase from Candida rugosa was then covalently bound to the magnetic polymercoated microspheres by using 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDAC) as an activation re
Abstract: A magnetic composite poly(styrene-methacrylic acid) microsphere, was prepared using oleic acid-coated magnetic nanoparticles as seeds by microemulsion copolymerization of styrene (St) and methacrylic acid (MAA). The lipase from Candida rugosa was then covalently bound to the magnetic polymer-coated microspheres by using 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride (EDAC) as an activation reagent. The immobilization of lipase could enhance the thermal and pH stability of lipase activity when compared to free lipase. The immobilized lipase microspheres were characterized by lipase activity assays, Fourier transform infrared spectroscopy, powder X-ray diffraction, transmission electron microscopy, and vibrating-sample magnetometer techniques. The bound lipase showed high activities to soybean oil transesterification with methanol to produce biodiesel. It was found that the oil conversion of 86% was attained at a reaction temperature of 35 °C for 24 h. The immobilized lipase is stable with re...

175 citations

Journal ArticleDOI
TL;DR: In this article, the lower critical solution temperature (LCST) of MEO2MA-stat-MAA decreased with the increasing molar fraction of MAA in the copolymer in deionized water but increased in buffer solution at pH 7.
Abstract: Dual responsive molecular brushes consisting of statistical copolymers of di(ethylene glycol) methyl ether methacrylate (MEO2MA) and either methacrylic acid (MAA) or N,N-dimethylaminoethyl methacrylate (DMAEMA) were synthesized by grafting from poly(2-(2-bromoisobutyroyloxy)ethyl methacrylate (PBIEM) macroinitiators using atom transfer radical polymerization (ATRP). Copolymer brushes with controlled composition and molecular weights ranging from Mn = 600 000 to 1 400 000 with polydispersity indexes (Mw/Mn) between 1.18 and 1.45 were obtained. The lower critical solution temperature (LCST) of MEO2MA-stat-MAA decreased with the increasing molar fraction of MAA in the copolymer in deionized water but increased in buffer solution at pH 7. At pH 9, the hydrophilicity of polymer increased with ionization of carboxylic acid to further raise the LCST. On the other hand, the LCST of MEO2MA-stat-DMAEMA copolymers increased with increasing DMAEMA content at pH 4, 7, and 9. A bottle-brush terpolymer prepared from all...

174 citations

Journal ArticleDOI
TL;DR: In this article, molecular imprinting of polymeric membranes with molecular recognition sites for l-phenylalanine (l-Phe), 6-amino-1-propyluracil (APU), atrazine, and sialic acid has been used.
Abstract: New types of polymeric membranes with molecular recognition sites for l-phenylalanine (l-Phe), 6-amino-1-propyluracil (APU), atrazine, and sialic acid have been prepared using the molecular imprinting approach. The membrane synthesis includes radical polymerization of ethylene glycol dimethacrylate (EDMA) and functional monomers in the presence of a template. Several compounds(diethylamino)ethyl methacrylate (DEAEM), methacrylic acid (MAA), allylamine (AA), and (4-vinylphenyl)boronic acidwere as functional monomers, which are able to form covalent, ionic, or hydrogen bonds with the corresponding templates. Template specific conductometric sensors, based on these polymers, were constructed and studied. An opposite response of covalently versus noncovalently imprinted membranes was demonstrated and discussed in detail. Sensors based on these materials could detect the target molecules at concentrations of 1−50 μM in solution. The high specificity and stability of these imprinted membranes render them promis...

174 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023135
2022211
2021141
2020225
2019285
2018308