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Methacrylic acid

About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.


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Journal ArticleDOI
TL;DR: Molecular imprints were prepared using L‐phenylalanine anilide as the print molecule and methacrylic acid as the functional monomer, and enantiomeric resolution was obtained for amide derivatives of amino acid ranging from alanine to tryptophan on a single polymer.
Abstract: Molecular imprints were prepared using L-phenylalanine anilide as the print molecule and methacrylic acid as the functional monomer. Methacrylic acid interacts ionically with the primary amine of the print molecule and via hydrogen bonding with the amide function. In the HPLC mode such polymers were shown to exhibit efficient enantiomeric resolution of a racemic mixture of the original print molecule. Enantiomeric resolution was shown to be dependent on the ratio of methacrylic acid to print molecule in the pre-polymerization mixture and specific for the presence of both print molecule and functional monomer. Further analyses showed the importance of both the primary amino and amide functions in the correct stereochemistry for recognition and enantiomeric resolution of compounds on such polymers. Other amide derivatives of amino acids including p-nitroanilides, beta-naphthylamides and amides were recognized by such polymers, and enantiomeric resolution was obtained for amide derivatives of amino acid ranging from alanine to tryptophan on a single polymer. The implications of these findings with respect to the mechanism of recognition and the ability to predict enantiomeric resolution of molecules on molecularly imprinted polymers will be discussed.

46 citations

Journal ArticleDOI
TL;DR: Investigations indicate that pectin-co-poly(MAA) hydrogel is a suitable delivery system developed for oral delivery of the drug targeted to the colon.
Abstract: In this communication, we developed a thermally stable, biocompatible, and colonically degradable hydrogel-based device [pectin-co-poly(MAA)] for oral delivery of 5-fluorouracil (5-FU) to treat colon cancer with minimal upper gastrointestinal invasion. Toward this end, ethylene glycol dimethacrylate (EGDMA) cross-linked hydrogels of pectin were synthesized. Methacrylic acid (MAA) was grafted to impart pH-responsive character, whereas benzoyl peroxide (BPO) was applied for simultaneous grafting and cross-linking polymerization. The hydrogels were characterized by Fourier transform infrared , thermogravimetric analysis, differential scanning calorimetry, and X-ray diffractometry. Scanning electron microscopic photographs were taken to analyze the surface morphology. Swelling behavior was analyzed to assess better performance of biodegradable hydrogels for optimized loading and release of the drug targeted to the colon. Gel fraction, swelling ratio, diffusion coefficient, drug loading, and cumulative release increased with an increase of pectin ratio and decreased with an increase of MAA and EGDMA ratio. Strategically, hydrogels with higher amounts of pectin were prepared for complete degradation in the colon. Our investigations indicate that pectin-co-poly(MAA) hydrogel is a suitable delivery system developed for oral delivery of the drug targeted to the colon.

46 citations

Journal ArticleDOI
TL;DR: In this paper, the relationship between thermal behavior and structural change was studied by an organized combination of isothermal DSC thermograms and FT-IR spectra so as to investigate the stabilization reactions of acrylonitrile/acrylamide (AN/AAM) copolymer.
Abstract: Relationship between thermal behavior and structural change was studied by an organized combination of isothermal DSC thermograms and FT-IR spectra so as to investigate the stabilization reactions of acrylonitrile/acrylamide (AN/AAM) copolymer in comparison with those of acrylonitrile/methacrylic acid (AN/MAA) copolymer and polyacrylonitrile (PAN). The isothermal DSC exothermic thermogram of the AN/AAM copolymer was broader than that of the AN/MAA copolymer and a little sharper than that of PAN, indicating that structural changes during stabilization proceed in the AN/AAM sample more slowly than that in the AN/MAA copolymer and more rapidly than PAN homopolymer.

46 citations

Journal ArticleDOI
TL;DR: Results showed the ability of MIP polymers to control the release of citalopram, and the imprinted polymers showed a higher affinity for citalolpram and a slower release rate than the nonimprinted polymers.
Abstract: In this work, the use of molecularly imprinted polymers (MIPs) for citalolpram as anti-depressant drug was studied Imprinted polymers were prepared from methacrylic acid (MAA; functional monomer), ethylene glycol dimethacrylate (EGDMA; cross-linker), and citalopram (as a drug template) using bulk polymerization method The polymeric devices were further characterized by FT-IR, thermogravimetric analysis, scanning electron microscopy, and binding experiments The dissolution media employed in controlled release studies were hydrochloric acid at the pH level of 43 and phosphate buffers, at pH levels of 72 and 101, maintained at 370 and 250 ± 05°C Results showed the ability of MIP polymers to control the release of citalopram In all cases, the imprinted polymers showed a higher affinity for citalopram and a slower release rate than the nonimprinted polymers At the pH level of 43 and at the temperature of 25°C, slower release of citalopram imprinted polymer occurred

46 citations

Journal ArticleDOI
TL;DR: These hydrogels can become an excellent candidates for colon targeting of OXP to treat colorectal cancer with no toxicity and are confirmed as non-toxic and biocompatible for biological system.
Abstract: An oral route of administration is a most acceptable route for a patient, so we designed chemically cross-linked polyethylene glycol-co-poly(methacrylic acid) oral hydrogels (PEGMA 4000) by free radical polymerization method for pH-responsive colon target delivery of oxaliplatin (OXP) Polyethylene glycol (PEG 4000) was cross-linked chemically with methacrylic acid (MAA) in distilled water Ammonium peroxodisulfate (APS) and N, N-methylene bisacrylamide (MBA) were used as initiator and cross-linker respectively OXP was loaded in prepared hydrogels FTIR, DSC, TGA, SEM, and XRD were conducted for characterization of developed hydrogels which endorsed the formation of new polymeric network The pH-sensitive behavior of hydrogels was observed by swelling dynamics and equilibrium swelling ratio at low (12) and higher pH (74) Toxicity study was also conducted on rabbits to evaluate toxicity and biocompatibility of developed carrier system to biological system Hydrogels with higher PEG 4000 concentration showed maximum swelling and higher drug loading at 74 pH Toxicity study confirmed the developed hydrogels as non-toxic and biocompatible for biological system Resultantly, these hydrogels can become an excellent candidates for colon targeting of OXP to treat colorectal cancer with no toxicity

46 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023135
2022211
2021141
2020225
2019285
2018308