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Methacrylic acid

About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.


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Patent
14 Sep 1983
TL;DR: In this article, the adhesive composition comprises a copolymer monomeric acrylic or methacrylic acid ester of non-tertiary alcohol and macromolecular monomer.
Abstract: The invention provides normally tacky and pressure-sensitive adhesive compositions comprising a polymer having an inherent viscosity greater than 0.2 and having in its backbone at least a major portion by weight of polymerized monomeric acrylic or methacrylic acid ester of a non-tertiary alcohol and, having attached to the backbone, polymeric moieties having a weight average molecular weight of above about 2,000 and a T g of above about 20° C. The number and composition of the attached moieties in the polymer is such as to provide the adhesive composition with a shear holding value of at least 50 minutes. Sheet materials coated with the adhesive composition are also provided. Preferred adhesive composition comprises a copolymer monomeric acrylic or methacrylic acid ester of non-tertiary alcohol and macromolecular monomer. The copolymer may also include up to 12% by weight of a copolymerizable polar monomer such as acrylic acid.

148 citations

Journal ArticleDOI
TL;DR: It is proposed that hydrolases in saliva increase the wear rate of composite resin fillings as well as the rate constants of the enzymatic hydrolysis of various (di)methacrylates.
Abstract: Di- and monomethacrylates hydrolyze to methacrylic acid and the alcohol part at neutral pH catalyzed by an unspecific esterase (hydrolase) and by enzymes in saliva. The rate constants of the enzymatic hydrolysis of various (di)methacrylates increase in the following order: HPMA less than BISGMA less than LAMA less than DECMA less than TEGDMA less than UEDMA less than DEGDMA. Esterase added to aqueous slurries of various powders made of polymerized BISGMA/TEGDMA-mixtures gave rise to liberation of methacrylic acid, presumably deriving from degradation of those of the dimethacrylates only bonded in the matrix by one end of the molecule. It was estimated that a TEGDMA-polymer will be hydrolyzed faster than a BISGMA-polymer. It is proposed that hydrolases in saliva increase the wear rate of composite resin fillings.

147 citations

Journal ArticleDOI
TL;DR: The results obtained clearly indicate that the timolol release rate is critically affected by the conditions under which the hydrogels were synthesized.
Abstract: The aim of this study was to analyse the influence of the template/functional monomer proportion on the achievement of molecularly imprinted hydrogels with cavities with a high enough affinity for the drug to sustain drug release. Imprinted hydrogels were prepared from N,N-dimethylacrylamide and tris(trimethylsiloxy)sililpropyl methacrylate (DMAA and TRIS; main components), methacrylic acid (MAA; functional monomer), ethylene glycol dimethacrylate (EGDMA; cross-linker), and timolol (template drug). Photo-polymerization of the monomer solutions was carried out in poly(propylene) molds (0.3 mm thickness) to obtain contact lens-like devices. Non-imprinted control hydrogels were also prepared in the same way but without the addition of timolol. The imprinted hydrogels showed a higher affinity for timolol and a slower release rate than the non-imprinted hydrogels. The release rate decreased by increasing the MAA/timolol ratio in the gel recipe. Hydrogels prepared with 400 x 10(-3) M MAA, 600 x 10(-3) M EGDMA, and a timolol/MAA mole ratio of 1:16-1:32 had drug diffusion coefficients two orders of magnitude below those of non-imprinted hydrogels. The results obtained clearly indicate that the timolol release rate is critically affected by the conditions under which the hydrogels were synthesized. These effects are discussed on the basis of the influence of drug proportion on the conformation of the imprinted cavities.

147 citations

Journal ArticleDOI
TL;DR: In this article, neutral temperature responsive polymers, such as poly(N-vinylcaprolactam) and poly(vinyl methyl ether) (PVME), were included in ultrathin films using layer-by-layer alternating adsorption of these polymers with poly(methacrylic acid) (PMAA) at low pH.
Abstract: Neutral temperature responsive polymers, such as poly(N-vinylcaprolactam) (PVCL) and poly(vinyl methyl ether) (PVME), were included in ultrathin films using layer-by-layer alternating adsorption of these polymers with poly(methacrylic acid) (PMAA) at low pH. The amounts of polymers adsorbed and ionization of carboxylic groups within a film were quantified using in situ FTIR-ATR (Fourier transform infrared spectroscopy by attenuated total reflection). The strength of interlayer adhesion provided through hydrogen-bonding interactions was inferred from the critical pH value (pHCR) and critical ionization (αCR) for multilayer decomposition which were pHCR 6.2, αCR 2% and pHCR 6.95, αCR 30% for PMAA/PVME and PMAA/PVCL films, respectively. When deposited onto porous support membranes, PMAA/PVME and PMAA/PVCL multilayers exhibited temperature-responsive changes in dye permeability. The transition occurred in a wide temperature range from 25 to 35 °C, reflecting lower cooperativity of the phase separation of PVME...

144 citations

Journal ArticleDOI
TL;DR: The results of the cytotoxicity assays demonstrated that the blank microgels were nontoxic to normal cells while DOX-loaded micro gels presented efficient antitumor activity to HeLa cells.

144 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023135
2022211
2021141
2020225
2019285
2018308