Topic
Methacrylic acid
About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.
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TL;DR: The purpose of the study was to investigate and identify the interactions within solid dispersions of cationic drugs and anionic polymers processed by hot-melt extrusion (HME) technique and found intermolecular ionic interactions varied according to the drug-polymer miscibility.
134 citations
TL;DR: In this article, the propagation rate coefficient, kp, for free-radical polymerization of nonionized methacrylic acid (MAA) in aqueous solution has been studied via pulsed laser polymerization (PLP) in conjunction with size-exclusion chromatography (SEC).
Abstract: The propagation rate coefficient, kp, for free-radical polymerization of nonionized methacrylic acid (MAA) in aqueous solution has been studied via pulsed laser polymerization (PLP) in conjunction with aqueous-phase size-exclusion chromatography (SEC). The PLP−SEC experiments were carried out between 20 and 80 °C within the entire concentration range from dilute solution containing 1 wt % MAA up to bulk MAA polymerization. The kp values which are determined under the assumption that the relevant monomer concentration at the radical site is identical to the known overall MAA concentration decrease by about 1 order of magnitude between 1 and 100 wt % MAA. This significant lowering is almost entirely due to a reduction in the Arrhenius preexponential factor, A(kp), whereas the activation energy, EA(kp), stays essentially constant. The decrease in A(kp) is assigned to intermolecular interactions between the transition state (TS) structure for MAA propagation and an MAA environment being significantly stronger...
134 citations
TL;DR: The nonionized gel structure was found to be rather insensitive to the amount of cross-linker, tetraethylene glycol dimethacrylate (TEGDMA), incorporated, within the range of 0.5 to 3%.
Abstract: Poly(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels can swell extensively in a high-pH medium where the carboxyl groups are ionized. The swelling equilibrium is a strong function of the methacrylic acid composition of the polymer and pH of the medium. The nonionized gel structure was found to be rather insensitive to the amount of cross-linker, tetraethylene glycol dimethacrylate (TEGDMA), incorporated, within the range of 0.5 to 3%. This result is supportive of the existence of secondary interactions that shield the effect of covalent cross-links. Phenylpropanolamine (PPA) was used as a probe solute to study the diffusion characteristics of the poly(HEMA-co-MA) gels. Its diffusion coefficient in the swollen matrices of different methacrylic acid compositions at various pH's was measured via a desorption method. It is evident that these diffusion coefficients follow Yasuda's free volume theory, which expresses an exponential relationship between the solute diffusivity in a swollen polymer membrane and the reciprocal of the membrane hydration. Although interactions exist between PPA and the hydrogel matrix, these interactions are not significant enough to perturb the free volume relationship established. This observation can be explained by the high ionic strength of the system.
133 citations
TL;DR: This study examined the binding of a series of biomolecules to poly(methylmethacrylate) (PMMA) and three HEMA-based hydrogels by use of a quartz crystal microbalance with dissipation (QCM-D) monitoring.
133 citations
TL;DR: In this paper, a commercially available thin film composite polyamide (PA) nanofiltration (NF) membrane was chemically modified to improve its rejection capacity for selected organic micro-pollutants categorized as endocrine disrupting chemicals (EDCs) and pharmaceutically active compounds (PhACs): bisphenol-A (BPA), ibuprofen, and salicylic acid).
132 citations