Methacrylic acid

About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.

Fabrication and Characterization of a Novel Anticancer Drug Delivery System: Salecan/Poly(methacrylic acid) Semi-interpenetrating Polymer Network Hydrogel.

Abstract: Salecan is a novel linear extracellular polysaccharide with a linear backbone of 1–3-linked glucopyranosyl units. Salecan is suitable for preparing hydrogels for biomedical applications due to its prominent physicochemical and biological profiles. In this contribution, a variety of innovative semi-interpenetrating polymer network (semi-IPN) hydrogels consisting of Salecan and poly(methacrylic acid) (PMAA) were developed via free radical polymerization for controlled drug delivery. The successful fabrication of the semi-IPNs was verified by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and thermogravimetric (TGA) measurements. Scanning electron microscopy (SEM) and rheology analyses demonstrated that the morphological and mechanical behaviors of the resultant hydrogels were strongly affected by the contents of Salecan and cross-linker N,N′-methylenebis(acrylamide) (BIS). Moreover, the swelling properties of these hydrogels were systematically investigated, and the results indica...

Adsorption of proteins from artificial tear solutions to contact lens materials.

Abstract: A series of polymers and copolymers of 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) were synthesized in order to find surfaces that would adsorb minimal amounts of protein. The adsorption of albumin, lysozyme and immunoglobulin G from a three-way mixture of these proteins in isotonic buffered saline to the polymers was measured using /sup 125/I-labeled proteins. Apparently high protein uptake on copolymers rich in HEMA was found to be due to sorption of unbound /sup 125/I by the polymers. /sup 125/I sorption by the polymers was minimized by dialysis of the protein solution to remove unbound /sup 125/I iodide and inclusion of 0.01 M sodium iodide to block uptake of residual /sup 125/I iodide. Using these improved protocols, minimal total protein uptake was observed on copolymers containing 50% or more HEMA. The majority of adsorbed protein on all p(MMA-HEMA) polymers was albumin. Total protein uptake was greatest on pMMA. Commercial contact lenses composed of copolymers of HEMA and N-vinyl pyrrolidone (NVP) or acrylamide (AAm) adsorbed small amounts of all proteins whereas copolymers of methacrylic acid (MAAc) and HEMA adsorbed much larger quantities of lysozyme. These results indicate that protein uptake by contact lens materials varies greatly with polymer composition. Artifactuallymore » high adsorption can occur if precautions are not taken to prevent uptake of unbound /sup 125/I.« less

Interaction of Poly(methacrylic acid) Brushes with Metal Ions: Swelling Properties

Abstract: The swelling behavior of poly(methacrylic acid) (PMAA) brushes in contact with aqueous solutions of sodium, silver, alkaline-earth metal, copper, and aluminum nitrate was studied by multiple angle null ellipsometry. Fundamentally different swelling behavior were found for the interaction of the polyacid brush with metal cations of increasing valency or when going from a main group to a transition metal ion at constant valency. The different cations were classified with respect to the nature of their interaction with the surface-attached poly(carboxylic acid), and the findings were compared to theoretical predictions as well as to experimental investigations of related systems, such as free polyacids in solution or polyacid gels interacting with different metal cations.