Topic
Methacrylic acid
About: Methacrylic acid is a research topic. Over the lifetime, 13058 publications have been published within this topic receiving 173201 citations. The topic is also known as: α-Methacrylic acid & 2-Methylacrylic acid.
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Patent•
11 Feb 1975
TL;DR: In this article, the authors describe the synthesis of cationic hydrogels by simultaneous polymerization and cross-linking in the presence of a polymerization catalyst, such as an organic peroxide, azobisisobutyronitrile or other free radical polymerization catalyzer.
Abstract: Novel cationic hydrogels, containing basic (cationic) groups in their molecular structure, and processes for their preparation are described. These novel hydrogels are stable, three-dimensional polymer networks, having good water permeability and mechanical properties. They are obtained by simultaneous polymerization and cross-linking in the presence of a polymerization catalyst, such as an organic peroxide, azobisisobutyronitrile or other free radical polymerization catalyst, of a mixture of (a) a heterocyclic monomer preferably an N-vinyl lactam, (b) a cationic monomer -- usually an ester of acrylic or methacrylic acid with an amino alcohol, the terminal amino group of which may be quaternized, such as dimethylaminoethyl methacrylate or acrylate and the quaternized derivatives thereof, and (c) a cross-linking agent, such as a glycol or polyglycol diacrylate or dimethacrylate and also, preferably, (d) at least one acrylic monomer capable of polymerizing to a very high molecular weight, such as hydroxyethyl- or hydroxypropyl-acrylate or methacrylate, or a lower alkyl acrylate or methacrylate; if desired there may also be present in the monomer mixture (e) other polymerizable ethylenically unsaturated monomers, which are copolymerizable with components (a), (b), (c) and (d). The thus obtained cationic hydrogels are useful for combining by reaction or complexing, with water soluble or dispersible materials having an opposite charge; such as acidic or anionic agricultural chemicals (insecticides, herbicides, fungicides, plant growth regulators, etc.), germicides, pharmaceuticals, cosmetics, hormones, enzymes, flavors, fragrances, antiperspirants, metals and the like, both to recover such acidic or anionic materials from an aqueous medium and for purifying water containing them, and also for the preparation of a complex or other combination of the cationic hydrogel with such anionic materials which may be useful per se or from which the complexed or combined acidic or anionic material may be slowly or controllably released.
79 citations
TL;DR: Polymers of this type may have great potential in controlling, via means of formulation, the release of drug eutomer whilst enhancing retention of distomer in the dosage form.
79 citations
TL;DR: Findings suggest that the PEG-b-poly(alkyl(meth)acrylate-co-methacrylic acid)s can self-assemble to form micelles which exhibit high loading capacities for CDN and release the drug in a pH-dependent fashion.
79 citations
TL;DR: In vitro drug release behavior of IPN hydrogels were investigated under different environments using model drugs 5-fluorouracil and the results suggested that such an IPn hydrogel can be exploited as carrier candidate for colon-specific drug delivery.
79 citations
TL;DR: By in vitro cellular experiments, it was confirmed that the porphyrazine-loaded micelles were PDT-active against A549 cells, and the corona composition strongly influenced their in vitro PDT activity, which decreased with increasing PEGylation, correlating with the cellular uptake of the micells.
Abstract: We describe the preparation of well-defined multicompartment micelles from polybutadiene-block-poly(1-methyl-2-vinyl pyridinium methyl sulfate)-block-poly(methacrylic acid) (BVqMAA) triblock terpol...
79 citations