Showing papers on "Methyl isobutyl ketone published in 1988"
TL;DR: Procedures have been developed for the selective determination of Cr(VI), and the simultaneous determination of (Cr(III) + Cr( VI)) without the need to convert Cr( III) toCr(VI).
Abstract: The solution conditions and other parameters affecting the ammonium pyrrolidinecarbodithioate-methyl isobutyl ketone (APCD-MIBK) extraction system for the graphite furnace atomic absorption spectrometric determination of Cr(III) and Cr(VI) have been studied in detail. The parameters studied include pH of the aqueous phase prior to extraction, concentration of APDC, concentration of the potassium hydrogen phthalate buffer, the length of time needed for complete extraction, and the time-stability of the chelate in the organic phase. On the basis of these studies, procedures have been developed for the selective determination of Cr(VI), and the simultaneous determination of (Cr(III) + Cr(VI)) without the need to convert Cr(III) to Cr(VI). The value of Cr(III) is obtained by difference. The methods have been applied to the determination of Cr(III), Cr(VI), and (Cr(III) + Cr(VI)) in some natural and drinking water samples. The detection limits (3 standard deviations of blank) for Cr(III) and Cr(VI) are the same and found to be 0.3 ng/mL in the MIBK phase. Data are presented on accuracy, precision, and interference.
159 citations
TL;DR: The hollow fiber contained liquid membrane (CLM) is a thin liquid film contained in the interstices of two sets of intermingled microporous hollow fine fibers as mentioned in this paper.
Abstract: The hollow fiber contained liquid membrane (CLM) is a thin liquid film contained in the interstices of two sets of intermingled microporous hollow fine fibers. Organic CLM-s have been used here for the separation of solutes from an aqueous feed into an aqueous strip. Solutes studied are phenol and acetic acid. The separations are carried out in either hydrophilic or hydrophobic hollow fiber CLM permeator modules, using a variety of organic liquids (e.g., decanol, methyl isobutyl ketone, xylene) as membranes. First-order models have been developed to predict the overall solute transfer coefficients adequately. The transfer coefficient can be enhanced significantly when a chemical reaction is carried out on the strip side using NaOH. The advantages of the CLM structure include operational stability, independent control of membrane phase pressure, automatic replenishment of the lost membrane liquid, and absence of the need for preequilibration. These features are demonstrated here, even for systems with considerable aqueous-organic mutual solubilities.
102 citations
TL;DR: The presence of a marginal response only at the highest, cytotoxic concentration tested in the ML assay, the lack of reproducibility in the CT assay, and clearly negative results in the Ames assay, UDS and MN assays suggest that MiBK is unlikely to be genotoxic in mammalian systems.
Abstract: 3 ketone solvents (methyl ethyl ketone (MEK), methyl isobutyl ketone (MiBK), and isophorone) were tested for potential genotoxicity. The assays of MEK and MiBK included the Salmonella/microsome (Ames) assay, L5178Y/TK+/- mouse lymphoma (ML) assay, BALB/3T3 cell transformation (CT) assay, unscheduled DNA synthesis (UDS) assay, and micronucleus (MN) assay. Only the ML, UDS, and MN assays were conducted on samples of isophorone. No genotoxicity was found for MEK or isophorone. The presence of a marginal response only at the highest, cytotoxic concentration tested in the ML assay, the lack of reproducibility in the CT assay, and clearly negative results in the Ames assay, UDS and MN assays, suggest that MiBK is unlikely to be genotoxic in mammalian systems.
48 citations
TL;DR: All of the solvents gave a negative response in the bacterial mutation assays and the yeast mitotic gene conversion assay and in cultured mammalian cells (either rat liver or Chinese hamster ovary) for structural chromosome damage.
Abstract: Two hydrocarbon solvents (heptane and Special Boiling Point Spirit 100/140) and eight oxygenated solvents [methyl ethyl ketone, methyl isobutyl ketone, diacetone alcohol, di-isobutyl ketone, isopropyl ether, hexylene glycol, secondary butyl alcohol and ME 6K (pentoxone)] have been tested for genotoxic activity. The solvents were tested in bacterial mutation assays, a yeast assay for mitotic gene conversion and in cultured mammalian cells (either rat liver or Chinese hamster ovary) for structural chromosome damage. All of the solvents gave a negative response in the bacterial mutation assays and the yeast mitotic gene conversion assay. In the rat liver chromosome assay, diacetone alcohol evoked a weak positive response, the remaining solvents gave a negative response.
40 citations
TL;DR: Solvent-containing products for plastic miniature hobby and industrial application were analyzed for solvent constituents by capillary gas-chromatography, finding acetone and methyl isobutyl ketone were two most extensively used solvents both in terms of frequency and concentration.
Abstract: Solvent-containing products (8 paint, 29 glue and 4 thinner preparations) for plastic miniature hobby were analyzed for solvent constituents by capillary gas-chromatography. Acetone and methyl isobutyl ketone were two most extensively used solvents both in terms of frequency and concentration. Other popular solvents included ethyl alcohol and two esters of ethyl acetate and butyl acetate. In contrast, aromatics, chlorinated hydrocarbons and ethylene glycol derivatives were seldomly detected. The present findings were discussed in comparison with the observation on the materials abused for sniffing in the past, as well as constituents in the products for industrial application.
27 citations
TL;DR: In this article, the authors investigated the way in which the selection of the best solvent or combinations of solvents can lead to a significant improvement in resist performance by influencing both the sensitivity and the contrast on development.
24 citations
TL;DR: In this paper, a method for determining platinum and palladium in rocks and soils is developed based on extraction of iodo complexes of these elements into methyl isobutyl ketone (MIBK), followed by electrothermal atomic absorption spectrometry of the extracts.
19 citations
Patent•
09 Nov 1988TL;DR: In this paper, the authors proposed an improvement to a process for making zirconium metal from uranium-containing Zircon ore using methyl isobutyl ketone.
Abstract: This is an improvement to a process for making zirconium metal from uranium-containing zircon ore. The process being improved is of the type which utilizes a fluidized bed carbochlorination process of the zircon ore in which uranium chloride is volatilized at the ore chlorinator temperature and follows as an impurity in the zirconium-hafnium tetrachloride stream, and in which removal of iron impurities is performed by liquid-liquid iron extraction with methyl isobutyl ketone, and the zirconium-hafnium stream is further processed by a separations step to reduce the hafnium content to low levels by liquid-liquid hafnium extraction. The improvement comprises adding 1-9 weight percent quaternary ammonium halide (e.g. tricaprylmethylammonium chloride) to the methyl isobutyl ketone in the liquid-liquid iron extraction. In this manner, the methyl isobutyl ketone strips uranium and iron from the zirconium-hafnium stream chloride solution and thus uranium does not end up in the hafnium chlorinator residue and yield of hafnium can increase by recycling of the hafnium chlorinator residue. In addition, exposure of personnel to uranium is minimized, and production of relatively pure, marketable uranium hydroxide and essentially uranium-free zirconium oxide are made possible.
16 citations
TL;DR: Results show that MIBK metabolites can potentiate the cholestatic form of hepatotoxicity, and 4-methyl-2-pentanol administered repetitively was a better potentiator than 4-OHMIBK with the Mn-BR model of cholESTasis, however, with Mn alone, 4- OHMIK proved to be more effective.
14 citations
TL;DR: In this paper, a coupled biological fluidized bed system, operated in the pre-denitrification mode, was used to evaluate its potential in implementing nitrogen removal from raw and diluted coking plant wastewaters and coal liquefaction condensates.
Abstract: A coupled biological fluidized bed system, operated in the pre‐denitrification mode, was used to evaluate its potential in implementing nitrogen removal from raw and diluted coking plant wastewaters and coal liquefaction condensates. The latter wastewater was also subjected to pretreatment by solvent extraction with light oil, methyl isobutyl ketone (MIBK) and 2‐octanone, and anaerobic degradation to evaluate the improvement in nitrification. Complete nitrification and denitrification was achieved for raw and diluted coking plant wastewater and for diluted and solvent extracted coal liquefaction condensates. Maximum specific nitrification rates increased with increasing dilution. Increased intensity of pretreatment led to stable nitrification at lower dilutions. Anaerobic pretreatment offered a possible alternative to solvent extraction. A complex tradeoff exists between the intensity of pretreatment, the degree of dilution and the size of the downstream biological treatment system.
13 citations
Patent•
12 Apr 1988
TL;DR: In this article, the authors proposed a method to obtain the titled polymer having little residue of Cl and elements of added catalyst an suitable as a protecting film of semiconductor, by hydrolyzing phenyltrichlorosilane with ultra-pure water in an organic solvent and washing the hydrolyzed product with ultrapure water.
Abstract: PURPOSE: To obtain the titled polymer having little residue of Cl and elements of added catalyst an suitable as a protecting film of semiconductor, by hydrolyzing phenyltrichlorosilane with ultra-pure water in an organic solvent and washing the hydrolyzed product with ultra-pure water. CONSTITUTION: (A) Phenyltrichlorosilane is dissolved in (B) an organic solvent of high-purity chemical grade for electronic industry use (e.g., methyl isobutyl ketone), the solution is cooled preferably to -10W20°C, (C) ultra-pure water having a specific resistance of ≥16MΩ.cm is dripped to the solution in an amount of preferably 3W30mol. pts. per 1mol. pt. of the component A to effect the reaction and the reaction product is washed after the recovery of the organic solvent phase to obtain a prepolymer. The prepolymer is added with preferably 0.05W5wt.% of a nucleophilic reagent (e.g., potassium hydroxide), subjected to dehydrative condensation and purified by dissolution reprecipitation process to obtain the polymer of formula (n is 7W1,600) containing ≤1ppm of Na, K, Fe, Cu, Zn and Cl and ≤1ppb of U and Th. COPYRIGHT: (C)1989,JPO&Japio
TL;DR: In this article, a new method suitable for the trace analysis of the metal in ores, alloys, plant tissues, animal tissues, and natural waters is presented based on the selective extraction of niobium as its complex with N-p-methoxyphenyl-2-furylacrylohydroxamic acid (MFHA) in organic solvents.
Abstract: The status of niobium in the environment is briefly reviewed and a new method suitable for the trace analysis of the metal in ores, alloys, plant tissues, animal tissues, and natural waters is presented. The method is based on the selective extraction of niobium as its complex with N-p-methoxyphenyl-2-furylacrylohydroxamic acid (MFHA) in organic solvents. For molecular absorption spectrophotometric analysis chloroform is used in extraction and a ternary complex is formed in the extract by adding 4-(2-pyridylazo) resorcinol (PAR). The ternary complex has an absorbance maximum at 550nm (e=3.6 × 104 1 mole−1 cm−1). Solvent extraction from the aqueous phase to lower volumes of organic phase enables up to 20-fold enrichment of niobium(V) and the method is capable of determining niobium levels down to 10−4 ppm (0.1 ppb). For the atomic absorption spectrometric determination, methyl isobutyl ketone is used as extracting solvent and a sensitivity of 0.3 ppm, which is over 3 times higher than attained so ...
TL;DR: Copper and zinc were extracted together as their thiocyanate complexes into methyl isobutyl ketone and determined by atomic absorption spectrometry with a tungsten-strip atomizer as discussed by the authors.
TL;DR: In this article, the solution properties of PMMA in mixtures of methyl isobutyl ketone with methanol were studied by viscometry and laser light scattering.
Patent•
31 May 1988
TL;DR: In this paper, the authors proposed to obtain high-purity Au by washing an Au-containing organic phase after Au extraction with an acid aqueous solution of a specific concentration and by allowing impurity Ag contained in the organic phase to pass into an acid-aqueous phase at the time of carrying out Au refining by a solvent extraction method.
Abstract: PURPOSE:To easily obtain high-purity Au by washing an Au-containing organic phase after Au extraction with an acid aqueous solution of a specific concentration and by allowing impurity Ag contained in the organic phase to pass into an aqueous phase at the time of carrying out Au refining by a solvent extraction method. CONSTITUTION:An Au material containing Ag, etc., as impurities is dissolved in aqua regia. Next, Au is extracted with an extraction reagent such as methyl isobutyl ketone, diisobutly ketone, diisopropyl ketone, etc. After that, an Au- containing organic phase after Au extraction is washed with an aqueous phase consisting of an acid of 2-16N concentration (e.g., hydrochloric acid, sulfuric acid) so as to allow impurity Ag contained in the organic phase to pass into the aqueous phase. Subsequently, the Au-containing organic phase is subjected to reverse extraction with an alkali solution to allow Au to pass into the alkali solution and then reduced, so that desired high-purity Au powder is obtained. In this way, high-purity Au of 99,99% purity can be easily obtained.
TL;DR: In this paper, the extraction of nitric acid from concentrated phosphoric acid solutions by methyl isobutyl ketone (MIBK) dissolved in aromatic diluent has been studied.
Abstract: The extraction of nitric acid from concentrated phosphoric acid solutions by methyl isobutyl ketone (MIBK) dissolved in aromatic diluent has been studied. Nitric acid can be effectively removed by MIBK from the solutions containing 50–75% H3P04. With increasing the concentration of either H3PO4 or MIBK, the distribution coefficient of HN03 increases but the separation factor for HN03 against H3PO4 decreases. However, it is possible to achieve a complete removal of HN03 in a few of stages and the coextraction of H3PO4 can be limited to less than 1%.
TL;DR: In this paper, the Wilson equation was used to measure boiling temperatures for four binary systems of methyl isobutyl ketone (4-methyl-2-pentanone) with chlorobenzene, o -dichlorobenzenes, bromobensene and p -xylene at 300, 500 and 700 mmHg.
TL;DR: Brown, K. K., and Poole, C. F., Coddens, M. C., Fish, R. E., and Casida, J. C. as mentioned in this paper.
Abstract: (1] Poole, C. F., and Schuette, S. A., Contemporary Practice of Chromatography, Elsevier, Amsterdam (1984). [2] Poole, C. F., Coddens, M. E., Butler, H. T., Schuette, S. A., Ho, S. S. J., Khatib, S., Piet, L., and Brown, K. K., J. Liq. Chrom. 8, 2875 (1985). 131 Laughlin, R. B., Guard, H. E., and Coleman, W. M., Env. Sci. Tech. 20, 201 (1986). (4] Woggon, H., and Jehle, D., Die Nahr. 17, 739 (1973). [5] Kimmel, E. C., Fish, R. H., and Casida, J. E., J. Agr. Food Chem. 25, 1 (1977). (6] Vasundhara, T. S., and Danhar, D. B., Fres. Z. Anal. Chem. 294, 408 (1979). [71 Ohlsson, S. V., and Hintze, W. W., J. High Resol. Chrom. & Chrom. Comm. 6, 69 (1983). [8] Arakawa, Y., Wada, O., and Manabe, M., Anal. Chem. 55, 1901 (1983). [9] Sherman, J., TLC Technical Series Vol. 2, Whatman Chemical Separation Inc., New Jersey, 1981. [101 Brown, K. K., and Poole, C. F., J. High Resol. Chrom. & Chrom. Comm. 7, 520 (1984). [II] Brown, K. K., and Poole, C. F., L. C. Mag. 2, 526 (1984). Determination of Chromium(III) and Chromium(VI) by Ammonium Pyrrolidine DithiocarbamateMethyl Isobutyl Ketone-Furnace Atomic Absorption Spectrometry
Patent•
28 Mar 1988
TL;DR: In this article, a method to obtain a titled compound useful as a solvent by one stage readily in high selectivity and high yield, by reacting acetone previously containing water substantially with H2 in the presence of a catalyst comprising oxide of Ce, etc., and Pd as essential components.
Abstract: PURPOSE:To obtain the titled compound useful as a solvent by one stage readily in high selectivity and high yield, by reacting acetone previously containing water substantially with H2 in the presence of a catalyst comprising oxide of Ce, etc., and Pd as essential components. CONSTITUTION:Acetone previously containing 2-100mol%, preferably 5-30mol% water based on acetone is reacted with H2 in the presence of a catalyst comprising an oxide such as CeO2, etc., or a hydroxide such as Ce(OH)4, etc., and Pd such as Pd/C, etc., as essential components in a liquid phase, preferably at 30-200 deg.C under >=pressure of acetone spontaneous generation and to give the aimed compound while suppressing formation of 9C ketones as by-products. The oxide or the hydroxide of Ce used as the catalyst is obtained by well-known various methods such as an alkali action on a solution of soluble cerium salt, hydrolysis of alkoxide, thermal decomposition of unstable cerium compound, oxidation of metallic Ce.
TL;DR: An indirect method for determination of phosphorus by atomic-absorption spectrophotometry has been developed, based on formation of the bismuthophosphomolybdate complex and its extraction by methyl isobutyl ketone.
Patent•
08 Apr 1988
TL;DR: In this paper, a copolymer solution of a concentration of 20-80wt, obtained by copolymersizing 0-20wt% rubbery polymer (A) such as a butadiene polymer with 30 -80wt% aromatic vinyl monomer (B) [eg, (alpha-methyl)styrene], 20-60wt% unsaturated dicarboxylic acid imide derivative (E) (N- methylmaleimide) (D) (eg, methyl methacrylate) in a solvent, such as methyl isobut
Abstract: PURPOSE:To obtain the title resin being excellent in strength, heat resistance and moldability and undergoing no flashing, by feeding a solution or the like of a rubber polymer and a copolymer containing aromatic vinyl monomer residues, unsaturated dicarboxylic acid imide derivative residues, etc to a specified extruder and extruding it CONSTITUTION:A copolymer solution of a concentration of 20-80wt%, obtained by copolymerizing 0-20wt% rubbery polymer (A) such as a butadiene polymer with 30-80wt% aromatic vinyl monomer (B) [eg, (alpha-methyl)styrene], 20-60wt% unsaturated dicarboxylic acid imide derivative monomer (eg, N- methylmaleimide) and 0-20wt% other copolymerizable vinyl monomer (D) (eg, methyl methacrylate) in a solvent, etc, such as methyl isobutyl ketone is fed to a multistage vented codirectional twin-screw extruder in which the screws have one or two pairs of left-handed screw threads and extruded by operating this extruder so that the ratio of the polymer discharge quantity Q(kg/hr) to the revolution speed of screw, NS(rpm), may satisfy the relationship of the formula to obtain the title imide group-containing resin
Patent•
11 Oct 1988
TL;DR: In this paper, a noble metal is formed in an org. solvent by adding the chloroplatinic acid and an extractant in an aq. soln. After the complex is shaken for one day, the org. phase is separated and the complex of the chloratinic acids and extractant is extracted in the anq. phase.
Abstract: PURPOSE:To form fine particles of a noble metal in an org. solvent by adding the org. solvent contg. an extractant in an aq. soln. of water soluble salts of the noble metal to prepare the complex of the metal salt and extractant and extracting this complex in the org. solvent then reducing the complex. CONSTITUTION:The org. solvent of chloroform, methyl isobutyl ketone or toluene contg. distearyl dimethyl ammonium chloride, trioctyl methyl ammonium chloride and octyl aniline is added as the extractant to the aq. soln. of the chloroplatinic acid to prepare the complex of the chloroplatinic acid and extractant at the time of producing the fine particles of, for example, Pt. After the complex is shaken for one day, the org. phase is separated and the complex of the chloroplatinic acid and extractant is extracted in the org. phase. A reducing agent such as formalin and additives such as water and NaOH or water and triethyl amine are added thereto to reduce the complex. The fine particles of Pt having an extremely small diameter are thus stably dispersed and formed in the org. solvent.
TL;DR: Atomic-absorption methods for determination of antimony at mug/g levels in rocks and sulphide ores by flame atomization and electrothermal atomization have been described.
Patent•
12 Mar 1988
TL;DR: In this paper, a water-repellent powder is used as a sprayable solid lubricant and as an additive for a waterbased paint to furnish the cast film with water repellency.
Abstract: PURPOSE:To obtain the title dispersion free from any surfactant and lowly toxic at a low cost, by dispersing a water-repellent powder in a hardly water-soluble org. solvent having a dielectric constant within a predetermined range, blending the dispersion with water, and separating an aq. phase. CONSTITUTION:A hardly water-soluble org. solvent having a dielectric constant of 10-40 (e.g., methyl isobutyl ketone or cyclohexanone) is mixed with a water- repellent powder (e.g., graphite fluoride or carbon black), thereby producing an oil dispersion of the water-repellent powder. The oil dispersion is blended with water to cause the water-repellent powder dispersed in the oil phase to be transferred into the water phase. The water phase is separated to obtain the desired aq. dispersion of the water-repellent powder. The above process enables the formation, without using any surfactant, of an aq. dispersion of a water-repellent powder having excellent stability and suitable for use as a sprayable solid lubricant and as an additive for a water-based paint to furnish the cast film with water-repellency.
Patent•
02 Sep 1988TL;DR: In this paper, a three-layered reaction product has been presented, having MIBK solvent on top, ammonium thiocyanate solution in the middle, and a highly pure hafnium hydroxcide sludge at the bottom which is separately removed, freed of water and calcined.
Abstract: In the production of a highly pure hafnium oxide by calcination of a highly pure hafnium hydroxide, the production of a highly pure hafnium hydroxide from a hafnium-loaded, methyl isobutyl ketone solvent that is substantially free of zirconium and sulfate ions by adding ammonia to such solvent to produce a three-layered reaction product having MIBK solvent on top, ammonium thiocyanate solution in the middle, and a highly pure hafnium hydroxcide sludge at the bottom which is separately removed, freed of water, and calcined
TL;DR: In this article, the atomic absorption spectrophotometric determination of manganese after extractive separation from aqueous media as its ternary complex with nicotinohydroxamic acid and trioctyl-methylammonium cation into methyl isobutyl ketone was presented.
Abstract: A rapid, sensitive and accurate method is presented for the atomic absorption spectrophotometric determination of manganese after extractive separation from aqueous media as its ternary complex with nicotinohydroxamic acid and trioctyl-methylammonium cation into methyl isobutyl ketone. The method permits determination of up to 0.002 ppm (2ppb) of manganese without any pretreatment and up to 0.1 ppb with pretreatment. The method was applied to the determination of manganese in natural waters and industrial effluents.
DOI•
01 Oct 1988TL;DR: In this paper, the pH 1/2 values for extracting different metals with 5 v/v% LIX 622 extractant in methyl isobutyl ketone (MIBK) have been obtained.
Abstract: The extraction characteristics of some selected metals from an aqueous buffered solution by LIX 622, a commercial oxime extractant have been studied. The pH1/2 values for extracting different metals with 5 v/v% LIX 622 extractant in methyl isobutyl ketone (MIBK) have been obtained. The order of extraction of metals with LIX 622 extractant as a function of pH1/2 value is determined and results agree well with the order obtained using salicylaldoxime as chelating ligand for the extraction of these metals.
Patent•
07 Apr 1988
TL;DR: In this article, a process for the production of a sterile composition containing lecithin and polyvinyl pyrrolidone is disclosed in order to render the ingredients sterile, and the process is used to produce injectable compositions of amoxycillin and ampicillin.
Abstract: A process for the production of a sterile composition containing lecithin and polyvinyl pyrrolidone is disclosed in which the lecithin and polyvinyl pyrrolidone, optionally with one or more preservative powders are admixed in a solvent comprising about 75% to 90% methyl isobutyl ketone and about 10% to 25% isopropyl alcohol, and the solution passed through a millipore filter in order to render the ingredients sterile. The process is usefully employed in the production of injectable compositions of amoxycillin and ampicillin.
Patent•
26 May 1988
TL;DR: In this article, a thermal receiving sheet is constituted of the porous layer 3 provided on a base material 1 and the receiving layer 4 provided on the porosity layer 3, which is formed by a method wherein a thermoplastic resin is dissolved in an org. solvent at first to solidify the resin and subsequently, water is evaporated to form voids.
Abstract: PURPOSE:To provide a thermal receiving layer easy to rise in image density, by providing a porous layer between a base material and a receiving layer. CONSTITUTION:A thermal receiving sheet 1 is constituted of the porous layer 3 provided on a base material 1 and the receiving layer 4 provided on the porous layer 3. As the base material 2, cellulose fiber paper, synthetic paper and a plastic film are designated. The porous layer 3 is formed by a method wherein a thermoplastic resin is dissolved in an org. solvent having a limit in the mutual solubility with water and water is added to the resulting solution to obtain a W/O type emulsion which is, in turn, applied to the base material 2 and dried to volatilize the org. solvent at first to solidify the resin and, subsequently, water is evaporated to form voids. As the thermoplastic resin, polyurethane, polyester, a vinyl chloride/vinyl acetate copolymer and the like are designated and, as the org. solvent, methyl ethyl ketone, methyl isobutyl ketone, ethyl acetate and the like are designated. When a resin layer 5 is provided to the surface opposite to the receiving layer, said resin layer 5 achieves function preventing curling.
Patent•
28 Nov 1988
TL;DR: In this paper, a method to produce the titled compound useful as a raw material for medicines by simple operation in a short time, by subjecting benzyl chloride and hydroxyphenones to dehydrochlorination reaction using methyl isobutyl ketone as a solvent.
Abstract: PURPOSE:To economically produce the titled compound useful as a raw material for medicines by simple operation in a short time, by subjecting benzyl chloride and hydroxyphenones to dehydrochlorination reaction using methyl isobutyl ketone as a solvent. CONSTITUTION:Benzyl chloride and hydroxyphenones are reacted preferably in the presence of a dehydrochlorinating agent, such as potassium carbonate, in methyl isobutyl ketone as a reaction solvent to afford the aimed benzyloxyphenones expressed by the formula (R is H, alkyl or phenyl; R1 and R2 are H, alkyl, alkoxy or phenyl). The reaction temperature for carrying out the reaction is the refluxing temperature of the methyl isobutyl ketone, i.e. 105-115 deg.C, and the amount of the methyl isobutyl ketone used is 300-600g, preferably 400-500g based on 1mol. hydroxyphenones. Hydrolysis of the benzyl chloride can be suppressed and amount of thereof used can be reduced by this method.