Topic
Methylglyoxal
About: Methylglyoxal is a research topic. Over the lifetime, 2844 publications have been published within this topic receiving 102037 citations. The topic is also known as: acetylformaldehyde & pyruvaldehyde.
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TL;DR: The findings suggest that methylglyoxal induced a significant rise in [Ca2+]i in Madin-Darby canine kidney (MDCK) renal tubular cells by stimulating both extracellular Ca2+ influx and CCCP-sensitive intracellular Ca 2+ release via as yet unidentified mechanisms.
47 citations
TL;DR: The modified protein was found to be more effective than HbA(0) in H(2)O(2)-mediated iron release and oxidative damages involving Fenton reaction and may enhance oxidative stress and associated complications, particularly in diabetes mellitus with increased level of MG.
47 citations
TL;DR: It is concluded that the primary step in the reaction involves the formation of a Schiff base linkage between the lysine side chain and methylglyoxal, reaffirm the concept that aldehydes can act as electron acceptors in charge transfer interactions with proteins.
Abstract: Spectroscopic measurements are reported for the effects of pH, time, solvent, and chemical modification of arginine and lysine side chains on the reaction of proteins with methylglyoxal. The reaction responsible for the appearance of a brown coloration and increased submolecular electronic activity in the proteins involves the epsilon-amino groups of the lysine residues. It is concluded that the primary step in the reaction involves the formation of a Schiff base linkage between the lysine side chain and methylglyoxal. These findings reaffirm the concept that, by the formation of Schiff bases, aldehydes can act as electron acceptors in charge transfer interactions with proteins.
47 citations
TL;DR: Pressure-broadened quantitative infrared spectra of glyoxal, methylglyoxAl, and diacetyl vapors covering the 520-6500 cm(-1) range are reported, representing some of the first quantitative intensity data for these analytes.
Abstract: Glyoxal, methylglyoxal, and 2,3-butanedione (diacetyl) are all known biomass burning effluents and suspected aerosol precursors. Pressure-broadened quantitative infrared spectra of glyoxal, methylglyoxal, and diacetyl vapors covering the 520–6500 cm–1 range are reported at 0.112 cm–1 resolution, each with a composite spectrum derived from a minimum of 10 different sample pressures for the compound, representing some of the first quantitative intensity data for these analytes. Many vibrational assignments for methylglyoxal are reported for the first time, as are some near-IR and far-IR bands of glyoxal and diacetyl. To complete the vibrational assignments, the far-infrared spectra (25–600 cm–1) of all three vapors are also reported, those of methylglyoxal for the first time. Density functional theory and ab initio MP2 theory are used to help assign vibrational modes. Potential bands for atmospheric monitoring are discussed.
47 citations
TL;DR: In this paper, the specific molecular basis linking DM with increased vulnerability to cardiovascular injury remains incomp incomprehensive, but it is known that DM is closely related to cardiovascular morbidity and mortality.
Abstract: Diabetes mellitus (DM) is closely related to cardiovascular morbidity and mortality, but the specific molecular basis linking DM with increased vulnerability to cardiovascular injury remains incomp...
47 citations