Topic
Methylglyoxal
About: Methylglyoxal is a research topic. Over the lifetime, 2844 publications have been published within this topic receiving 102037 citations. The topic is also known as: acetylformaldehyde & pyruvaldehyde.
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TL;DR: The results indicate that there are two forms of S-adenosylmethionine decarboxylase, and the presence of a particular form could, therefore, be important both in the regulation of polyamine levels and also in the pharmacology involving inhibitors of polyamines synthesis.
Abstract: S-Adenosylmethionine decarboxylase was purified to homogeneity from rat liver and from rat psoas. The major step involved affinity chromatography on methylglyoxal bis-(guanylhydrazone) linked to Sepharose. The muscle enzyme was more tightly retained to this absorbent, and the enzymes from the two sources could readily be separated by chromatography on this material. The psoas and liver enzymes could not be distinguished by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate, both giving a single band corresponding to an Mr of 32 500, but were separated by electrophoresis under nondenaturing conditions and by isoelectric focusing (the isoelectric points were 5.3 for psoas and 5.7 for liver enzyme). The liver and psoas enzymes also differed in respect to Km for S-adenosylmethionine, the degree to which they were activated by putrescine, and their sensitivity to inhibition by methylglyoxal bis(guanylhydrazone) and related compounds. These results indicate that there are two forms of S-adenosylmethionine decarboxylase. The presence of a particular form could, therefore, be important both in the regulation of polyamine levels and also in the pharmacology involving inhibitors of polyamine synthesis.
42 citations
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TL;DR: Delphinidin could be a useful lead compound for the development of novel GLO I inhibitory anticancer drugs, according to computational simulation analyses of the binding modes of delphinids, cyanidin and pelargonidin to the enzyme hot spot.
42 citations
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TL;DR: Drosophila is an established model system to study signaling, neurodegeneration, and metabolic regulation in vivo, and data is provided suggesting that the previously reported deglycation activity of DJ-1 can be ascribed to a TRIS buffer artifact.
42 citations
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TL;DR: The data suggest that MG interferes directly in brain function and that the time and the levels of exogenous MG determine the different features that can be seen in diabetic patients.
42 citations
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TL;DR: MG-derived AGEs may have an important role as the precursors of protein aggregation, which, in turn, may be associated with physiological complications.
41 citations