scispace - formally typeset
Search or ask a question
Topic

Methylglyoxal

About: Methylglyoxal is a research topic. Over the lifetime, 2844 publications have been published within this topic receiving 102037 citations. The topic is also known as: acetylformaldehyde & pyruvaldehyde.


Papers
More filters
Journal ArticleDOI
TL;DR: A novel electrochemical sensor, based on the electrodeposition of platinum nanoparticles onto single wall carbon nanotubes that were cast on a glassy carbon electrode (GCE) substrate, is presented in this paper, which exhibited excellent catalytic activity in the electroreduction of methylglyoxal.

36 citations

Journal ArticleDOI
TL;DR: Results suggest that HT and its degradation product DOPAC could have a relevant role in preventing the formation of advanced glycation end products and therefore potentially mitigate the diabetic complications.

36 citations

Journal ArticleDOI
TL;DR: In this article, an endogenous carbonyl compound produced under hyperglycemic conditions, which may play a role in the pathogenesis of cardiac remodeling, was found to contribute to the development of cardiac fibroblasts.
Abstract: Cardiac fibroblasts contribute to the pathogenesis of cardiac remodeling. Methylglyoxal (MG) is an endogenous carbonyl compound produced under hyperglycemic conditions, which may play a role in the...

36 citations

Journal ArticleDOI
TL;DR: Alternative routes of methylglyoxal detoxification in T. brucei are discussed along with the potential of exploiting trypanosomatid glyoxalase enzymes as targets for anti-parasitic chemotherapy.

36 citations

Journal ArticleDOI
TL;DR: Findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction byprotect against glycosylation-related stress.
Abstract: Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

36 citations


Network Information
Related Topics (5)
Oxidative stress
86.5K papers, 3.8M citations
86% related
Protein kinase A
68.4K papers, 3.9M citations
80% related
Amino acid
124.9K papers, 4M citations
80% related
Programmed cell death
60.5K papers, 3.8M citations
79% related
Apoptosis
115.4K papers, 4.8M citations
79% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023112
2022306
2021173
2020156
2019153
2018128