scispace - formally typeset
Search or ask a question
Topic

Methylglyoxal

About: Methylglyoxal is a research topic. Over the lifetime, 2844 publications have been published within this topic receiving 102037 citations. The topic is also known as: acetylformaldehyde & pyruvaldehyde.


Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, aqueous phase photo-oxidation experiments of methylglyoxal and hydroxyl radical were conducted to simulate cloud processing. But little is known about the composition of secondary organic aerosol (SOA) formed through cloud processing, which may simplify the incorporation of oligomers into atmospheric SOA models.

309 citations

Journal ArticleDOI
TL;DR: The comparison of structural and enzymic features ofcarbonyl reductase with other monomeric oxidoreductases suggests a close relationship of carbonyl reductionase with prostaglandin 9-keto-reductase and xenobiotic ketone reduct enzyme.

308 citations

Journal ArticleDOI
TL;DR: The glyoxalase system is a metabolic pathway that catalyses the detoxification of alpha-oxoaldehydes RCOCHO to corresponding aldonic acids RCH(OH)CO2H, and protects cells from alpha-Oxoaldehyde-mediated formation of advanced glycation endproducts (AGEs).

306 citations

Journal ArticleDOI
TL;DR: Results provide chemical evidence for protein cross-linking by dicarbonyl compounds in vivo and name this cross-link imidazolysine, detected in proteins by high performance liquid chromatography using a postcolumn derivatization method.

297 citations

Journal ArticleDOI
TL;DR: A new integrative model of diabetic complications is proposed that combines the aldose reductase/polyol pathway theory and the nonenzymatic glycation theory except that emphasis is placed both on methylglyoxal/acetol metabolism and on glucose metabolism.

283 citations


Network Information
Related Topics (5)
Oxidative stress
86.5K papers, 3.8M citations
86% related
Protein kinase A
68.4K papers, 3.9M citations
80% related
Amino acid
124.9K papers, 4M citations
80% related
Programmed cell death
60.5K papers, 3.8M citations
79% related
Apoptosis
115.4K papers, 4.8M citations
79% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023112
2022306
2021173
2020156
2019153
2018128