Topic
Methylglyoxal
About: Methylglyoxal is a research topic. Over the lifetime, 2844 publications have been published within this topic receiving 102037 citations. The topic is also known as: acetylformaldehyde & pyruvaldehyde.
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TL;DR: It is likely that methylglyoxal undergoes a redox cycle and generates the free radicals which in turn lower the antioxidant status in animals, and the increased levels of lipid peroxidation provide support for the involvement of free radical processes in the detrimental effects of methyl glyoxal.
87 citations
TL;DR: The results are considered to be a possible explanation of many published observations of the appearance of methylglyoxal in glycolyzing tissues and the potential for methylglyxal formation in biological tissues and in certain buffer systems possibly has wide ranging metabolic implications.
86 citations
TL;DR: It is proposed that wild-type alpha-synuclein modulates brain glucose metabolism, and GLO1 induction in KO brain seems insufficient to prevent AGE formation.
Abstract: The presynaptic protein alpha-synuclein has received much attention because its gain-of-function is associated with Parkinson’s disease. However, its physiological function is still poorly understood. We studied brain regions of knock-out mice at different ages with regard to consistent upregulations of the transcriptome and focused on glyoxalase I (GLO1). The microarray data were confirmed in qPCR, immunoblot, enzyme activity, and behavior analyses. GLO1 induction is a known protective cellular response to glucose stress, representing efforts to decrease toxic levels of methylglyoxal (MG), glyoxal and advanced glycation endproducts (AGEs). Mass spectrometry quantification demonstrated a ubiquitous increase in MG and fructosyl-lysine as consequences of glucose toxicity, and consistent enhancement of certain AGEs. Thus, GLO1 induction in KO brain seems insufficient to prevent AGE formation. In conclusion, the data demonstrate GLO1 expression and glycation damage to be induced by alpha-synuclein ablation. We propose that wild-type alpha-synuclein modulates brain glucose metabolism.
86 citations
TL;DR: The results show that the glyoxalase system is another pathway in which the nearly ubiquitous glutathione is replaced by the unique trypanothione in trypanosomatids.
86 citations
TL;DR: Exogenous application of salicylic acid (SA) ameliorated the ill-effects of Ni by restoring growth, photosynthesis and physio-biochemical attributes and increasing the activities of enzymes associated with antioxidant systems, especially the ascorbate-glutathione cycle and glyoxalase system.
86 citations