Topic
Micronization
About: Micronization is a research topic. Over the lifetime, 837 publications have been published within this topic receiving 20253 citations.
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TL;DR: Supercritical antisolvent processing has been explored in a variety of different fields including: explosives, polymers, pharmaceutical compounds, coloring matter, superconductors, catalysts and inorganic compounds.
Abstract: Traditional micronization processes can be improved by taking advantage of the unique characteristics of the supercritical antisolvents that include very large diffusivities when compared with those of liquids and the one step complete elimination of the solvent from the precipitates. The application of supercritical antisolvent processing has until now been explored in a variety of different fields including: explosives, polymers, pharmaceutical compounds, coloring matter, superconductors, catalysts and inorganic compounds. In this review the experimental techniques currently available, results and present perspectives of application of this technique are critically examined and discussed.
606 citations
TL;DR: Common and novel techniques for the production of a drug in small particle size are summarized and the properties of the resulting products that are obtained by different techniques are characterized and compared.
Abstract: Drug powders containing micron-size drug particles are used in several pharmaceutical dosage forms. Many drugs, especially newly developed substances, are poorly water soluble, which limits their oral bioavailability. The dissolution rate can be enhanced by using micronized drugs. Small drug particles are also required in administration forms, which require the drug in micron-size size due to geometric reasons in the organ to be targeted (e.g., drugs for pulmonary use). The common technique for the preparation of micron-size drugs is the mechanical comminution (e.g., by crushing, grinding, and milling) of previously formed larger particles. In spite of the widespread use of this technique, the milling process does not represent the ideal way for the production of small particles because drug substance properties and surface properties are altered in a mainly uncontrolled manner. Thus, techniques that prepare the drug directly in the required particle size are of interest. Because physicochemical drug powder properties are decisive for the manufacturing of a dosage form and for therapeutic success, the characterization of the particle surface and powder properties plays an important role. This article summarizes common and novel techniques for the production of a drug in small particle size. The properties of the resulting products that are obtained by different techniques are characterized and compared.
368 citations
TL;DR: Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a "top-down" approach in the production of fine particles as mentioned in this paper.
328 citations
TL;DR: Evaluating a novel in situ micronization method avoiding any milling techniques to produce nano- or microsized drug particles by controlled crystallization to enhance the dissolution rate of poorly water-soluble drugs found it suitable for the production of micro-sized drugs.
Abstract: Purpose. The purpose of this study was to evaluate a novel in situ micronization method avoiding any milling techniques to produce nano- or microsized drug particles by controlled crystallization to enhance the dissolution rate of poorly water-soluble drugs.
283 citations
TL;DR: The results suggest that cogrinding and spray-drying are powerful techniques for the preparation of rapidly dissolving formulations of fen ofibrate, and could potentially lead to improvements in the bioavailability of oral fenofibrate products.
282 citations