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Topic

Microscope

About: Microscope is a(n) research topic. Over the lifetime, 32258 publication(s) have been published within this topic receiving 571300 citation(s). The topic is also known as: šŸ”¬.


Papers
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Journal Articleā€¢DOIā€¢
Abstract: The scanning tunneling microscope is proposed as a method to measure forces as small as 10-18 N. As one application for this concept, we introduce a new type of microscope capable of investigating surfaces of insulators on an atomic scale. The atomic force microscope is a combination of the principles of the scanning tunneling microscope and the stylus profilometer. It incorporates a probe that does not damage the surface. Our preliminary results in air demonstrate a lateral resolution of 30 A and a vertical resolution less than 1 A.

11,795Ā citations

Journal Articleā€¢DOIā€¢
Abstract: Images and force measurements taken by an atomicā€force microscope (AFM) depend greatly on the properties of the spring and tip used to probe the sampleā€™s surface. In this article, we describe a simple, nondestructive procedure for measuring the force constant, resonant frequency, and quality factor of an AFM cantilever spring and the effective radius of curvature of an AFM tip. Our procedure uses the AFM itself and does not require additional equipment.

3,720Ā citations

Journal Articleā€¢DOIā€¢
Abstract: We describe a set of image processing algorithms for extracting quantitative data from digitized video microscope images of colloidal suspensions. In a typical application, these direct imaging techniques can locate submicrometer spheres to within 10 nm in the focal plane and 150 nm in depth. Combining information from a sequence of video images into single-particle trajectories makes possible measurements of quantities of fundamental and practical interest such as diffusion coefficients and pair-wise interaction potentials. The measurements we describe in detail combine the outstanding resolution of digital imaging with video-synchronized optical trapping to obtain highly accurate and reproducible results very rapidly.

3,060Ā citations

Bookā€¢
01 Jan 1991
Abstract: Principles of imaging Introductory nuclear magnetic resonance The influence of magnetic field gradients High resolution k-space imaging k-space microscopy in biology and minerals science The measurement of motion using spin echoes Structural imaging using q-space Spatially heterogeneous motion and dynamic NMR microscopy Elements of the NMR microscope.

2,887Ā citations

Journal Articleā€¢DOIā€¢
TL;DR: Lateral resolution that exceeds the classical diffraction limit by a factor of two is achieved by using spatially structured illumination in a wideā€field fluorescence microscope with strikingly increased clarity compared to both conventional and confocal microscopes.
Abstract: Lateral resolution that exceeds the classical diffraction limit by a factor of two is achieved by using spatially structured illumination in a wide-field fluorescence microscope. The sample is illuminated with a series of excitation light patterns, which cause normally inaccessible high-resolution information to be encoded into the observed image. The recorded images are linearly processed to extract the new information and produce a reconstruction with twice the normal resolution. Unlike confocal microscopy, the resolution improvement is achieved with no need to discard any of the emission light. The method produces images of strikingly increased clarity compared to both conventional and confocal microscopes.

2,863Ā citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202211
2021575
2020865
20191,056
20181,015
20171,000