Topic
Mimosine
About: Mimosine is a research topic. Over the lifetime, 496 publications have been published within this topic receiving 8812 citations. The topic is also known as: Leucenine & Leucaenine.
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TL;DR: The toxic principle contained in this plant is a water-soluble amino-acid termed leucenol, and is identical with mimosine obtained from Mimosa pudica, which seems to be the preferred name for the compound.
Abstract: Loss of hair in animals following ingestion of seeds and foliage of Leucaena glauca was first reported in 18971. Sudden loss of hair in native women has been ascribed to consumption of Leucaena glauca seeds2. The toxic principle contained in this plant is a water-soluble amino-acid termed leucenol, and is identical with mimosine obtained from Mimosa pudica3. Mimosine seems to be the preferred name for the compound, both by historical precedent4 and to avoid confusion with leucinol, an alcoholic derivative of leucine. Mimosine is found primarily in the seeds of Leucaena glauca, lesser amounts being present in the foliage and stems5. Its chemical structure is:
83 citations
TL;DR: It is found that mimosine-treated cells had a reduction in the pools of dGTP and dATP and that Mimosine inhibited ribonucleotide reductase in vitro in an iron-dependent manner.
82 citations
81 citations
TL;DR: Efficiency of Leucaena is demonstrated to mitigate in vivo methane emission of sheep, but it is not revealed which constituent of the plant was primarily responsible for that since no clear efficiency of either tannins or mimosine could be demonstrated.
Abstract: Leucaena (Leucaena leucocephala), a leguminous shrub promising to cope with feed scarcity in the tropics, may help in mitigating ruminal methane (CH4) emission in the tropics as well. Two experiments were conducted to evaluate the effect of Leucaena and major secondary compounds of this plant in ruminants. At first, effects of Leucaena tannins and mimosine on ruminal CH4 and nutrient degradability were tested in vitro. Incubations were made with Leucaena without or with polyethylene glycol (PEG) to exclude the tannins effects, as well as with Bermuda grass (Tifton) and lucerne hays, both either untreated or supplemented with mimosine at the same concentration that has been provided by the tested Leucaena (6.52 mg/g DM). Furthermore, in an in vivo experiment a control diet (per kg DM 700 g Tifton hay) and Leucaena diets (per kg DM 350 g Tifton hay and 350 g Leucaena), either with or without 20 g PEG/d per head, were evaluated in six Santa Ines sheep following a double Latin square design. In vitro, Leucaen...
71 citations
70 citations