Topic
Miscibility
About: Miscibility is a research topic. Over the lifetime, 5521 publications have been published within this topic receiving 133547 citations. The topic is also known as: miscible.
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TL;DR: A good correlation was observed between phase separation and reduced physical stability, suggesting that miscibility is indeed an important ASDs characteristic, and fluorescence-based techniques show promise in the evaluation of drug-polymer miscibility.
Abstract: The purpose of this study was to investigate the feasibility of using a fluorescence-based technique to evaluate drug–polymer miscibility and to probe the correlation between miscibility and physical stability of amorphous solid dispersions (ASDs). Indomethacin–hydroxypropyl methylcellulose (IDM–HPMC), indomethacin–hydroxypropyl methylcellulose acetate succinate, and indomethacin–polyvinylpyrrolidone (IDM–PVP) were used as model systems. The miscibility of the IDM–polymer systems was evaluated by fluorescence spectroscopy, fluorescence imaging, differential scanning calorimetry (DSC), and infrared (IR) spectroscopy. The physical stability of IDM–polymer ASDs stored at 40 °C was evaluated using fluorescence imaging and X-ray diffraction (XRD). The experimentally determined miscibility limit of IDM with the polymers was 50–60%, 20–30%, and 70–80% drug loading for HPMC, HPMCAS, and PVP, respectively. The X-ray results showed that for IDM–HPMC ASDs, samples with a drug loading of less than 50% were maintained...
57 citations
TL;DR: In this article, it was shown that ion-dipole interactions induce considerable miscibility enhancement in blends of styrene ionomers with poly(alkylene oxides) with dynamic mechanical studies, in conjunction with transparency and brittleness of the samples, are used to evaluate miscibility.
Abstract: It is shown that ion-dipole interactions induce considerable miscibility enhancement in blends of styrene ionomers with poly(alkylene oxides). Dynamic mechanical studies, in conjunction with transparency and brittleness of the samples, are used to evaluate miscibility. The effect is clearly thermodynamics in that phase separation can be induced in miscible samples by raising the temperature, with miscibility reestablished ons cooling. The miscibility enhancement in these systems is compared with that resulting from hydrogen bonding. In addition to the styrene/alkylene oxide system, ion-dipole interactions are found to be effective in enhancing the miscibility of many ionic polymer/polar polymer pairs. The ionomers used in this study were styrene lithium methacrylate and ethyl acrylate lithium acrylate copolymers, while polyethers, polysulfides, polyesters, polyimines, and substituted polyethylenses served as polar polymers.
57 citations
TL;DR: In this paper, the mixture of poly(butylene adipate-co-terephthalate (PBAT), polybutylene succinate (PBS) and linear low-density polyethylene (LLDPE) was blended to produce bio-based packaging via blown-film extrusion.
57 citations
TL;DR: In this paper, a novel organic-inorganic interpenetrating polymer network (IPN) was prepared via in situ crosslinking between octa(propylglycidyl ether) polyhedral oligomeric silsesquioxane (OpePOSS) and 2,2-bis(4-hydroxyphenyl)propane in the presence of poly(ethylene oxide) (PEO).
57 citations
TL;DR: In this article, a pair of dissimilar polymers with high molecular weights, poly(acrylonitrile-co-styrene) and poly(ACrylonitric lebutadiene), were found to exhibit both UCST and LCST (lower critical solution temperature) behavior.
Abstract: A pair of dissimilar polymers with high molecular weights, poly(acrylonitrile-co-styrene) poly(acrylonitrile-co-butadiene), was found to exhibit both UCST (upper critical solution temperature) and LCST (lower critical solution temperature) behavior. This phase behavior is interpreted by combining the solubility parameter theory involving the free volume term and the recent idea of “miscibility window” for the polymer blends including random copolymers.
57 citations