Topic
Miscibility
About: Miscibility is a research topic. Over the lifetime, 5521 publications have been published within this topic receiving 133547 citations. The topic is also known as: miscible.
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TL;DR: In this article, the microporous structure of composite coating layers is determined by controlling the phase inversion, specifically the solvent-nonsolvent miscibility, in the coating solutions.
170 citations
TL;DR: In this article, the specific volumes of three PEO/PVC blends (with weight ratio at 70/30, 50/50 and 30/70) as well as pure PEO and PVC are examined as a function of temperature.
170 citations
TL;DR: It is concluded that the balance between the thermodynamic factors (enthalpy and entropy of mixing) in a ternary water-drug-polymer system is the important factor in determining which solid dispersion systems are susceptible to moisture-induced amorphous-amorphous phase separation.
Abstract: It has been previously observed that exposure to high relative humidity (RH) can induce amorphous-amorphous phase separation in solid dispersions composed of certain hydrophobic drugs and poly(vinylpyrrolidone) (PVP). The objective of this study was to investigate if this phenomenon occurred in solid dispersions prepared using less hygroscopic polymers. Drug-polymer miscibility was investigated before and after exposure to high RH using infrared (IR) spectroscopy and differential scanning calorimetry (DSC). PVP, poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA), and hypromellose acetate succinate (HPMCAS) were selected as model polymers, and felodipine, pimozide, indomethacin, and quinidine were selected as model drugs. Drug-polymer mixing at the molecular level was confirmed for all model systems investigated. Moisture-induced drug-polymer demixing was observed in felodipine-PVPVA, quinidine-PVP, quinidine-PVPVA, pimozide-PVPVA, and pimozide-HPMCAS systems, but was absent in the other HPMCAS dispersions and for indomethacin-PVPVA. It is concluded that the balance between the thermodynamic factors (enthalpy and entropy of mixing) in a ternary water-drug-polymer system is the important factor in determining which solid dispersion systems are susceptible to moisture-induced amorphous-amorphous phase separation. Systems with strong drug-polymer interactions and a less hygroscopic polymer will be less susceptible to moisture-induced phase separation, while more hydrophobic drugs will be more susceptible to this phenomenon even at low levels of sorbed moisture.
169 citations
TL;DR: In this article, the effect of the molecular weight of poly(vinyl pyrrolidone) additive (M w : 360k and 40k) in two systems on membrane morphology has been investigated by the differences in phase separation rates and miscibility gaps.
169 citations
TL;DR: In this paper, a room temperature ionic liquid (IL), 1-butyl-3methylimidazolium hexafluorophosphate [BMIM][PF6], has been used to modify poly(vinylidene fluoride) (PVDF).
169 citations