Topic
Miscibility
About: Miscibility is a research topic. Over the lifetime, 5521 publications have been published within this topic receiving 133547 citations. The topic is also known as: miscible.
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TL;DR: In this paper, a negative polymer-polymer interaction energy density was calculated based on the melting depression of poly(ethylene oxide) using the Nishi-Wang equation, which indicated that PEO was miscible with PVPh-co-PMMA.
Abstract: Blends of poly(vinylphenol-co-methyl methacrylate) (PVPh-co-PMMA) with poly(ethylene oxide) (PEO) were prepared by solution casting from tetrahydrofuran (THF) solution. The miscibility behavior and hydrogen bonding of blends were investigated by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and solid-state nuclear magnetic resonance (NMR). Experimental results indicate that PEO was miscible with PVPh-co-PMMA as shown by the existence of single composition-dependent glass transition temperatures over the entire composition range by DSC. In addition, a negative polymer-polymer interaction energy density "B" was calculated based on the melting depression of PEO using the Nishi-Wang equation. Solid-state NMR reveals single-exponential decay of proton spin-lattice relaxation times in the rotating frame (T1F H ) in the amorphous PVPh-co- PMMA phase. Furthermore, FTIR and solid-state NMR results reveal that at least three competing equilibria are present in the blend; self-association of PVPh-co-PMMA copolymer (hydroxyl-hydroxyl and hydroxyl-carbonyl) and hydroxyl-ether interassociation between PVPh and PEO. Quantitative results show that although the hydroxyl-ether interassociation is favored at room temperature, the hydroxyl-carbonyl self-association dominates at higher temperatures (>70 °C). The Painter-Coleman association model (PCAM) can predict three interacting functional groups based on our experimental results at various temperatures.
121 citations
TL;DR: Evidence is provided for the miscibility between chitosan and cellulose in the solid state using 1-butyl-3-methylimidazolium acetate as solvent media and for the increased Ea for thermal decomposition for all the polymeric blends.
121 citations
TL;DR: Blends of poly(vinyl chloride), PVC, with the polyesters poly(butylene adipate), poly(hexamethylene sebacate, poly(2,2-dimethyl,1,3-propylene succinate) and poly(1,4-cyclohexanedimethanol succinate), were found to exhibit a single, composition dependent glass transition as mentioned in this paper.
121 citations
TL;DR: The solid dispersions are significantly supersaturated with respect to both crystalline solubility and amorphous miscibility demonstrating the influence of manufacturing methodology.
Abstract: Purpose
The present study aims to determine the drug / polymer miscibility level as a function of the preparation method for an amorphous solid dispersion model system containing itraconazole and eudragit E100 This value was compared to the theoretical crystalline drug solubility in the amorphous polymer and the miscibility of the amorphous drug in the amorphous polymer
120 citations
TL;DR: In this article, the mixture of chitosan and polyvinyl alcohol (PVA) was studied using viscosity, ultrasonic velocity and refractive index techniques at 30°C.
119 citations