Topic
Miscibility
About: Miscibility is a research topic. Over the lifetime, 5521 publications have been published within this topic receiving 133547 citations. The topic is also known as: miscible.
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TL;DR: In this paper, it was shown that propionitrile, the hydrogenated monomer of polyacrylonitrile (PAN), is very unsuitable as an analogue of the latter.
246 citations
TL;DR: The findings demonstrate that molecular modeling is a powerful technique for determining the solubility parameters and predicting miscibility of pharmaceutical compounds, and are in reasonable agreement with those calculated using group contribution methods.
Abstract: The objectives of this study were (i) to develop a computational model based on molecular dynamics technique to predict the miscibility of indomethacin in carriers (polyethylene oxide, glucose, and sucrose) and (ii) to experimentally verify the in silico predictions by characterizing the drug-carrier mixtures using thermoanalytical techniques. Molecular dynamics (MD) simulations were performed using the COMPASS force field, and the cohesive energy density and the solubility parameters were determined for the model compounds. The magnitude of difference in the solubility parameters of drug and carrier is indicative of their miscibility. The MD simulations predicted indomethacin to be miscible with polyethylene oxide and to be borderline miscible with sucrose and immiscible with glucose. The solubility parameter values obtained using the MD simulations values were in reasonable agreement with those calculated using group contribution methods. Differential scanning calorimetry showed melting point depression...
242 citations
TL;DR: In this article, a starch-based biodegradable film, with a nano silicon dioxide (nano-SiO2) content, was prepared by the coating method, through which its physical and biodesgradable properties were studied.
241 citations
TL;DR: In this article, the influence of coagulation solution composition on the spinning performance was discussed and the intermolecular interactions of blend fibers were studied by infrared analysis (IR), X-ray diffraction (XRD), and scanning electron micrograph (SEM) and by measurements of mechanical properties and water-retention properties.
Abstract: Chitosan and poly(vinyl alcohol) blend fibers were prepared by spinning their solution through a viscose-type spinneret at 25°C into a coagulating bath containing aqueous NaOH and ethanol. The influence of coagulation solution composition on the spinning performance was discussed, and the intermolecular interactions of blend fibers were studied by infrared analysis (IR), X-ray diffraction (XRD), and scanning electron micrograph (SEM) and by measurements of mechanical properties and water-retention properties. The results demonstrated that the water-retention properties and mechanical properties of the blend fibers increase due to the presence of PVA in the chitosan substract, and the mechanical strength of the blends is also related to PVA content and the degree of deacetylation of chitosan. The best mechanical strength values of the blend fibers, 1.82 cN/d (dry state) and 0.81 cN/d (wet state), were obtained when PVA content was 20 wt % and the degree of deacetylation of chitosan was 90.2%. The strength of the blend fibers, especially wet tenacity could be improved further by crosslinking with glutaraldehyde. The water-retention values (WRV) of the blend fibers were between 170 and 241%, obviously higher than pure chitosan fiber (120%). The structure analysis indicated that there are strong interaction and good miscibility between chitosan and poly(vinyl alcohol) molecular resulted from intermolecular hydrogen bonds. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 2558–2565, 2001
239 citations
TL;DR: In this paper, the miscibility of copolymer compositions has been studied by a film clarity test, Tg and cloud-point (Tp) studies, and the phase diagrams of the blends were determined.
237 citations