Topic
Mitsunobu reaction
About: Mitsunobu reaction is a research topic. Over the lifetime, 1887 publications have been published within this topic receiving 38990 citations.
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TL;DR: In this article, a series of tripeptide, and sulfonamido 9 hydroxamic acids which act as inhibitors of metalloproteinases have been prepared.
104 citations
TL;DR: The usefulness of the TMAD reagent was demonstrated by the highly efficient two-step synthesis of benzylcrotylamine from N-benzyltrifluoroacetamide, when used in combination with tributylphosphine in benzene.
Abstract: N,N,N′,N′-Tetramethylazodicarboxamide, TMAD, was found to be more versatile in the Mitsunobu reaction than traditional diethyl azodicarboxylate or recently developed 1,1′-(azodicarbonyl)dipiperidine, when used in combination with tributylphosphine in benzene. The usefulness of the reagent was demonstrated by the highly efficient two-step synthesis of benzylcrotylamine from N-benzyltrifluoroacetamide.
104 citations
TL;DR: The Mitsunobu reaction was efficiently used to introduce oxazolines and thiazolines in the peptide backbone as discussed by the authors, and the reaction proceeded from β-hydroxy αamino acid-containing peptides at room temperature in 58-72% isolated yields.
103 citations
TL;DR: A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
Abstract: A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
101 citations
TL;DR: Reaction of the Huisgen zwitterion, derived from triphenylphosphine and dialkyl azodicarboxylate, with allenic esters affords highly functionalized pyrazolines and pyrazoles.
99 citations