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Showing papers on "Molecular models of DNA published in 1994"


Book ChapterDOI
TL;DR: Using a set of Monte Carlo simulation models, track structures of 125I Auger electrons generated in liquid water are superimposed on a nucleosome DNA model able to precisely localize energy deposition events on sub-molecular units of the DNA strands to introduce different assumptions for strand break induction by both hit modes.
Abstract: Using a set of Monte Carlo simulation models, track structures of 125I Auger electrons generated in liquid water are superimposed on a nucleosome DNA model able to precisely localize energy deposition events on sub-molecular units of the DNA strands. After scoring direct hits taking place during the physical phase (at about 10−15 s) the radiation chemistry of the whole system is simulated between 10−12 and 10−8 s, taking into account all reactions between water radio-chemical species, radicals, sub-molecular units of DNA (Ribose, Adenine, Thymine, Guanine and Cytosine), and scavengers like Tris or Formate ions.

6 citations