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Mood disorders

About: Mood disorders is a research topic. Over the lifetime, 12320 publications have been published within this topic receiving 607769 citations.


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Book ChapterDOI
01 Jan 2019
TL;DR: Heart transplantation offers patients with end-stage heart disease an opportunity for many additional years of life, with relief of heart failure and resumption of valued activities and social roles, Nevertheless, psychiatric problems are common and may undermine quality of life and survival.
Abstract: Heart transplantation offers patients with end-stage heart disease an opportunity for many additional years of life, with relief of heart failure and resumption of valued activities and social roles. Nevertheless, psychiatric problems are common and may undermine quality of life and survival. Important problems following transplantation include delirium, cognitive dysfunction, mood disorders, anxiety, post-traumatic stress disorder, sexual dysfunction, sleep disorders, and marital and family dysfunction. Steroids, immunosuppressants, and other medicines used in care of transplant recipients may cause psychopathology. Few controlled treatment studies have been conducted in psychiatric care of post-heart transplant recipients, so most treatment is based on uncontrolled case series, clinical experience, and extrapolation from other patient populations. Psychopharmacologic treatments are based on consideration of anticipated adverse effect profiles and drug interactions.

2 citations

01 Jan 2014
TL;DR: In this review, main neuroendocrine-molecular changes and interactions that occur in the eating disorders have been discussed.
Abstract: There are three basic pillars for the development of eating disorders: genetic predisposition, neuroendocrine-molecular changes in the brain and metabolic response to it. As a result of neuroendocrine research, a close relationship has been found between neuroendocrine functions and symptom domains of psychiatric disorders such as eating disorders and mood disorders. Certain hormones, neurotransmitters and other molecules which might have effect on the basis of eating disorders can be listed as estrogen, serotonin, leptin, ghreline, alpha-melanocyte stimulating hormone, cholecystokinin, dopamine, noradrenaline, brain-derived neurotropic factor, agoutirelated protein, neuropeptide-Y, opioids and their receptors, thiamine, zinc, omega-3 acids. In this review, main neuroendocrine-molecular changes and interactions that occur in the eating disorders have been discussed.

2 citations

Patent
31 Jan 2018
TL;DR: In this article, the disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1, R 2, R 2 ′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND).
Abstract: The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 2 ′, and X are as defined as set forth in the specification, for use in treating cognitive deficits and/or psychiatric disorders, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND). Compounds having formula (I) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-L-norleucine (DON).

2 citations

01 Jan 2011
TL;DR: In this paper, the authors investigated how such biases are implemented in the brain and found that sad participants rejected more unfair offers than those in the neutral condition, thereby replicating their previous findings.
Abstract: Empirical evidence suggests that complex cognitive processes such as decisionmaking can be influenced by incidental affect (i.e. emotional states unrelated to the decision), which may have importance implications for furthering our understanding and treatment of mood disorders. Following up on previous behavioral findings suggesting that sad mood leads to biases in social decision-making, the present research first investigated how such biases are implemented in the brain. Nineteen adult participants made decisions that involved accepting or rejecting monetary offers from others in an Ultimatum Game (a well known economic task), while undergoing functional magnetic resonance imaging (fMRI). Prior to each set of decisions, participants watched a short video clip aimed at inducing either sadness or a neutral emotional state. Results indicated that sad participants rejected more “unfair” offers than those in the neutral condition, thereby replicating our previous findings. Neuroimaging analyses revealed that receiving unfair offers while in a sad mood elicited activity in brain areas related to aversive emotional states and somatosensory integration (anterior insula) and to cognitive conflict (anterior cingulate cortex). Sad participants also showed a diminished sensitivity in neural regions associated with reward processing (ventral striatum). Importantly, insular activation uniquely mediated the relationship between sadness and decision bias, demonstrating how subtle mood states can be integrated at the neural level to bias decision-making.

2 citations

01 Jan 2005
TL;DR: The presence of a significant number of manic/hypomanic items in patients with recurrent unipolar depression seems to challenge the traditional unipolar-bipolar dichotomy and bridge the gap between these two categories of mood disorders.
Abstract: Objective: This study examined the extent to which individuals with a lifetime diagnosis of recurrent unipolar disorder endorse experiencing manic/hypomanic symptoms over their lifetimes and compared their reports with those of patients with bipolar I disorder. Method: The study group included 117 patients with remitted recurrent unipolar depression and 106 with bipolar I. Subjects had their clinical diagnosis confirmed by the Mini International Neuropsychiatric Interview and were administered the Structured Clinical Interview for the Mood Spectrum, which assesses lifetime symptoms, traits, and lifestyles that characterize threshold and subthreshold mood episodes as well as “temperamental” features related to mood dysregulation. Results: The patients with recurrent unipolar depression endorsed experiencing a substantial number of manic/hypomanic symptoms over their lifetimes. In both patients with recurrent unipolar depression and patients with bipolar I disorder, the number of manic/hypomanic items endorsed was related to the number of depressive items endorsed. In the group with recurrent unipolar depression, the number of manic/hypomanic items was related to an increased likelihood of endorsing paranoid and delusional thoughts and suicidal ideation. In the bipolar I group, the number of lifetime manic/hypomanic items was related to suicidal ideation and just one indicator of psychosis. Conclusions: The presence of a significant number of manic/hypomanic items in patients with recurrent unipolar depression seems to challenge the traditional unipolar-bipolar dichotomy and bridge the gap between these two categories of mood disorders. The authors argue that their mood spectrum approach is useful in making a more accurate diagnostic evaluation in patients with mood disorders.

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023267
2022595
2021635
2020562
2019505
2018541