Topic
Morphogenesis
About: Morphogenesis is a research topic. Over the lifetime, 6816 publications have been published within this topic receiving 412940 citations.
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TL;DR: A coupling between physical adhesion and developmental signaling provides a mechanism to tightly integrate physical aspects of tissue morphogenesis with cell growth and differentiation, a coordination that is essential to achieve the intricate patterns of cells in tissues.
3,407 citations
TL;DR: P63 is essential for several aspects of ectodermal differentiation during embryogenesis, including hair follicles, teeth and mammary glands, which are absent in p63-deficient mice.
Abstract: The p53 tumour suppressor is a transcription factor that regulates the progression of the cell through its cycle and cell death (apoptosis) in response to environmental stimuli such as DNA damage and hypoxia1,2. Even though p53 modulates these critical cellular processes, mice that lack p53 are developmentally normal3, suggesting that p53-related proteins might compensate for the functions of p53 during embryogenesis. Two p53 homologues, p63 and p73, are known4,5 and here we describe the function of p63 in vivo. Mice lacking p63 are born alive but have striking developmental defects. Their limbs are absent or truncated, defects that are caused by a failure of the apical ectodermal ridge to differentiate. The skin of p63-deficient mice does not progress past an early developmental stage: it lacks stratification and does not express differentiation markers. Structures dependent upon epidermal–mesenchymal interactions during embryonic development, such as hair follicles, teeth and mammary glands, are absent in p63-deficient mice. Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis.
2,011 citations
TL;DR: A collection of protocols to culture MCF-10A cells, to establish stable pools expressing a gene of interest via retroviral infection, as well as to grow and analyzeMCF- 10A cells in three-dimensional basement membrane culture are provided.
1,957 citations
TL;DR: The JAW locus is identified, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.
Abstract: Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms
1,701 citations
Book•
01 Aug 1988
TL;DR: Proteoglycans and Hyaluronan in Morphogenesis and Differentiation, and Other Matrix Glycoproteins in Embryogenesis.
Abstract: Introductory Remarks.- I. What Is Extracellular Matrix?.- 1 Collagen.- 2 Proteoglycans: Structure and Function.- 3 The Elastic Fiber.- 4 Fibronectin and Other Cell Interactive Glycoproteins.- II. How Do Cells Produce the Matrix?.- 5 Proteoglycans: Metabolism and Pathology.- 6 Collagen Biosynthesis.- 7 Matrix Assembly.- 8 Extracellular Matrix Degradation.- III. What Does Matrix Do for Cells?.- 9 Proteoglycans and Hyaluronan in Morphogenesis and Differentiation.- 10 Integrins as Receptors for Extracellular Matrix.- 11 The Glomerular Basement Membrane: A Selective Macromolecular Filter.- 12 Collagen and Other Matrix Glycoproteins in Embryogenesis.
1,699 citations